July 2021: CAR T-Cell kurapwa mumamota akasimba kwakabvumidzwa muChina kune zvimwe zviratidzo uye mamaki. Munguva pfupi yapfuura, CAR T-Cell kurapa yakaongororwa gomarara rakasimba senge:
- Kansa yepabonde
- Kenza yemapapu isiri-diki-diki
- Kenza yechiropa
- Cholangiocarcinoma
- kenza yakajeka
- kenza yemudumbu
- Kenza yemammary
- kenza yegurokuro
- gomarara repancreatic
- Oophoroma
- Gomarara redundiro
- Kenza yechibereko
MOTO T-Cell pamakenza ese aya anoshanda kune varwere vanenge vadzokera shure mushure meimwe nzira dzekurapa dzakadai sekuvhiya, chemotherapy uye radiotherapy.
Ndiyo yekutanga MOTO T-Cell nyaya yakapoteredza pasi rose yekuti musikana ane makore mashanu anonzi Emily ane Leukemia akarapwa muna 5.
Jimmy Carter, makumi mapfumbamwe, aimbova mutungamiri weAmerica, akazivisa izvozvo melanoma masero akanga apararira kuchiropa nouropi.
Musi waZvita 6, 2015, nePD-1 antibody pamwe neradiotherapy, maseru egomarara muvivo akanyangarika.
Musi waMarch 6, 2016, akange asisade kurapwa kwemelanoma.
Musi waZvita 2, 2018, akaonekerawo pamariro evakafanobata Mutungamiri Bush.
Pakupera kwa2013, immunocytotherapy yakaverengerwa seimwe yepamusoro gumi tekinoroji kubudirira kwegore nemagazini yeScience.
Muna 2014, makonferensi maviri ane chiremera chegomarara, AACR neASCO, akaitwa muUnited States. Immunotherapy yave iyo yekutarisa yekucheka kumucheto tekinoroji. Muna 2014, FDA yakabvumira kunyorwa kwe nivolumab uye pembrolizumab.
CAR T Cell kurapwa kurapa kenza
Muna 2015, director wemufirimu Chen Xunqi akaonekwa kuti haana mutsauko chirwere chetachiona, akavhiyiwa uye chemotherapy yakawanda muBeijing, uye akarega chemotherapy;
Muna 2016, PS mamakisi ari matatu ari muchipatara, akaonda, uye akafunga kuyedza CAR T kurapwa mushure memakosi maviri ekuita tumarara disappear;
Muna 2017, yakaedzwa uye yakadzokororwa, zvakajairwa; mu2018, yakaedzwa ikatariswazve, zvakajairwa;
Chii chinonzi CAR T Cell Therap?
T masero anopinda bundu tishu, secrete immune checkpoint masoja ekudzivirira chirwere (PD-1, CTLA-4 uye mamwe masoja ekudzivirira chirwere), uye zvishoma nezvishoma anoshandura bundu remunharaunda immunosuppression microenvironment.
CAR-T muT masero anouraya chinangwa chemota uye inoburitsa cytokines kusimudza-kutonga MHC kutaura uye kufumura tumor antigens. Zvichakadaro, masoja ekudzivirira ekudzivirira zvirwere anoderedza bundu remunharaunda microenvironment T cell (TIL) inhibition, uye masero eT apinzwa anotanga Kutanga, kuita uye kuwanda.
CAR-T & TIL inogadzira musumbu musanganiswa, kushandura mamota munzvimbo yekurwira immune, kuuraya ese marudzi emota maseru pamwechete uye kuashandura kuita matumbu anopisa, kuparadza zvachose mamota uye kuumba inokonzeresa ndangariro T maseru, ichideredza mukana wekuti bundu ridzoke.
Side mhedzisiro yeCAR T-Cell kurapa mune yakasimba kenza kesi
Pavarwere makumi maviri nevashanu vaive negomarara rakasimba, makumi maviri nevashanu vakaenda kunoongororwa CAR T-Cell:
- high fever yakawanikwa muvarwere ve6
- dyspnea uye pneumonia zviratidzo muvarwere ve2
- 1 murwere ane ganda rakaoma uye dandruff
- hapana vamwe varwere vakaratidza kusaenzana kukuru.
Nyaya A: murwere wekenza yemapapu ari kurapwa neCAR T-Cell
Muna Mbudzi we2009, murwere akawana mapapu ekuruboshwe achibva aenda kuruboshwe kenza yemapapu kuvhiyiwa kukuru. Pathology: mapapu adenocarcinoma;
Kubva muna Ndira 2013 kusvika muna Ndira 2017, metastases nhatu dzehuropi dzakaitika, uye kuvhiyiwa uye kurapwa kwemwaranzi zvakapihwa zvakatevedzana nekutonga kwakashata;
Kubva munaKurume 2017 kusvika Gunyana 2017, kune metastases yeuropi, mesoCAR-αPD1 masero anoratidza PD-1 antibody akapihwa makosi matanhatu ekurapa. Mushure mekurapwa, PR yakaongororwa uye mapundu akaderera zvakanyanya aine zvishoma zvishoma zvakasara.
Nyaya B: Murwere wegomarara reTesticular ari kurapwa neCAR T-cell
Muna Nyamavhuvhu we2016, murwere akawana misa muscrotum chaiyo uye akavhiyiwa kurapwa. Pathology: embryonic rhabdomyosarcoma;
Muna March we2017, kuongorora kwePET-CT, kwakawana kuti peritoneum, omentum, uye intestine zvakanga zvisina kujeka, zvichifunga nezvemetastases yakawanda mudumbu remimba;
Kubva munaJune kusvika munaGunyana 2017, mesoCAR-αPD1 masero airatidza PD-1 antibody akapihwa 4 nguva. Mhedzisiro yacho yaive CR; metastases yese mudumbu yakaenda.
Nyaya C: Murwere weLung adenosquamous carcinoma anogamuchira CAR T-Cell therapy
Muna Mbudzi 2017, iyo yekuruboshwe yekumusoro yemapapu adenosquamous carcinoma (6.4 "2.9cm) yakaonekwa, ichiperekedzwa nemetastasis yekuruboshwe clavicle uye bilateral cervical lymph nodes. Akaendeswa kuchipatara kuti arapwe, uye Ⅲ uye V bone uye kuora mwoyo kweuropi kwakaitika mushure me3 chemotherapy , Matambudziko ane simba. Sarudza kuedza immunotherapy yakasanganiswa nechemotherapy.
Musi waNdira 2 naKukadzi 6, 2018, maviri immune cell infusions akaitwa, uye muviri wakavandudzwa zvakanyanya, uye mhedzisiro yechemotherapy yakadzikira zvishoma nezvishoma. Kuongororazve kwakaratidza kuti hapana re-metastasis yebundu kana kuwedzera.
Bvunzo pakupera kwaKukadzi 2018 dzakaratidza kuti maronda mumapapu akange adzikira zvakanyanya uye mamiriro egomarara anga atove pasi pekutonga.
Nyaya D: Murwere wekenza yeChiropa akawana CAR T-cell therapy
Musi waChikumi 1, 2017, bundu re66mm x 46mm rakaonekwa kumucheto wepamusoro wekuruboshwe lobe lung. Musi waJune 15th, akaendeswa kuOriental Hepatobiliary Surgery Hospital kuti arapwe. Zvichienderana nemhedzisiro yeCT-inotungamirirwa nemapapu puncture biopsy, chirongwa chekurapa-mune-chimwe chinosanganisa CAR-T cell immunotherapy, yakanangana nekurapa + chemotherapy yakagadzirwa. Musi waChikunguru 29, 2017, yekutanga immune cell infusion therapy yakaitwa. Mushure mokupinza, muviri wakaita zvakasimba. Pashure pokunge chimiro chake chagadzikana, chimiro chake chakavandudzika pakutanga. Mushure memwedzi inodarika mitanhatu ye immunotherapy yakasanganiswa neinonangwa kurapa, mamota ari mumuviri anga ari madiki zvakanyanya.
Nyaya E: Murwere wekenza yemapapu ane metastasis yeuropi akawana CAR T-cell therapy
Musi waMbudzi 26, 2009, bundu re 3.03 "2.39cm rakaonekwa murobe repamusoro remapapu ekuruboshwe, uye rokumusoro rekuruboshwe rakabviswa zvakananga uye zvachose pakutanga. Musi waNdira 25, 2013, chiveve kuruboshwe kuzasi kwekupedzisira kwakatadza kuona brain metastatic bundu Resection yemaronda akadzika pachiratidziro + yakanangwa kurapwa neIressa. 6 Muna Chikumi 2016, foci yakaita seshizha, yakakwidziridzwa zvisingaite yakaonekwa pamharadzano yekurudyi yefrontal-parietal lobe ye intracranial bundu resection. Muna 2017, brain tumor Kuora, bundu rinosvika 3.3 "2.8 cm, rakaonekwa mukati mekurudyi parietal lobe, uye akawanda meningeal metastases uye radiotherapy yakaitwa. 3Muna Kurume 2017, immunotherapy yakatanga. Kanokwana kana pamberi uye mushure mekupinza, bundu riri muuropi rakavandudza zvakanyanya.
Mhosva F: Murwere wekenza yegororo asina mutsauko anogamuchira CAR T-cell therapy
Muna 2016, akaonekwa aine chirwere chekenza yeutachiona. Quine ndiyo yakaipa mhando yechirwere chegomarara, uye vanachiremba vakaudza kuti kwasara mwedzi miviri chete yehupenyu. Mushure mekurapwa kwakawanda kweradiotherapy, akarasikirwa nemapaundi makumi matatu, asi muviri wake hauna kuzoita nani. Akazoramba kurapwa chemotherapy. Gare gare, ndakaenda kunoedza immunotherapy. Mushure memaviri immune immune infusions, maseru ekenza mumuviri akanyangarika zvachose.
Nyaya G: Murwere wekenza yeHypopharyngeal anogamuchira CAR T-Cell therapy
Muna Chikunguru 2014, akaonekwa aine hypopharyngeal carcinoma, linary sacral carcinoma. 2 makosi echemotherapy uye hypopharyngeal cancer kuvhiyiwa uye mutsipa wekurudyi dissection. Pashure pegore nehafu, akadzokororazve, ndokuenderera mberi neradiotherapy, panguva iyo migumisiro yakaipa yakanga iri pachena uye mamiriro ake omuviri akanga asina kunaka zvikuru. Pana Ndira 13, 2016, mana immune cell infusions akagamuchirwa zvakatevedzana. Mamiriro acho akatanga kugadzikana uye mamiriro acho akavandudzika zvakanyanya. Kubva munaChikunguru kusvika Zvita 2016, mamwe mashanu maseru infusions akaitwa, uye mamiriro emuviri akavandudzwa zvishoma nezvishoma, nekurara kwakajairika uye kuda kudya. Muchiitiko chekuoma mitezo pamubhedha kwemwedzi inoverengeka, uye tsandanyama zvishoma nezvishoma atrophied, uremu hwake hwakawedzera kubva 80 makirogiramu kusvika 112 makirogiramu.
Nyaya H: Murwere wegomarara rezamu rekuruboshwe ane brain metastasis anogamuchira CAR T-Cell therapy
Muna Ndira 2014, akabatwa zamu rakapararira kenza nemapapu uye chiropa metastases. Kubva muna Ndira kusvika munaNovember 2014, 9 chemotherapy masesheni akaitwa. Kubva muna Chikumi 2015, maseru egomarara akametastasized kuuropi, uye 11 cranial gamma banga kurapwa kwakaitwa, uye maseru egomarara akapararira zvachose. 3Muna Kurume 2017, kuHong Kong, vakagamuchira kurapwa kwePD-1 uye vachiri kutadza. Kutanga muna Kubvumbi 2018, takaedza CAR-T immunotherapy. Pashure peimwe nzira yokurapa, mugumisiro wacho wakanga unoshamisa. Kuzvimba kweuropi nechiropa zvakapera. Kuzvimba kwainge kwapararira nemapapu chete kwakangopararira. Yakaderedzwa kusvika ku1.2.
