Sept 2022: Kurapa kwemamota akasiyana kwakashandurwa ne cell-based immunotherapy, inowanzozivikanwa se CAR-T cell kurapa. Kuti utarise uye urwise mafomu chaiwo eukemia uye lymphoma, kurapwa kunoshandisa genetically engineered T masero. Kunyangwe iine mukana wekurapa gomarara mune vamwe vanhu vangangofa nechirwere ichi, inotakurawo njodzi yehuwandu hwemhedzisiro, dzimwe dzacho dzinogona kuuraya nekukanganisa kushanda kwehuropi.
Maererano neongororo ichangobva kuitwa kubva kuWashington University School of Medicine muSt. CAR-T cell kurapa. Vatsvagiri vakaona kuti mazinga eprotein inonzi neurofilament light chain (NfL) akakwira muvanhu vanozosangana nedambudziko reurotoxic mushure mekudzidza masampuli eropa akatorwa kubva kuvarwere vasati varapwa, panguva, uye mushure meCAR-T cell therapy. Kurapa kusati kwatanga, kune huwandu hwakawanda hweprotein iripo, uye iwo mazinga anogara akakwira mukati mekurapa uye kweanosvika mwedzi mushure.
Chidzidzo ichi, chakaburitswa munaGunyana 1 mujenari JAMA Oncology, chinogona kubatsira vashandi vekurapa kufanoona izvi zvinogona kuuraya mhedzisiro uye kuvagonesa kutanga kupa mishonga inogona kuderedza mhedzisiro yeurotoxic mukutanga kurapwa kwemurwere. Pamusoro pezvo, inopa puratifomu yekutanga CAR-T masero ekurapa mativi ekudzivirira kana tsvakiridzo yekudzikisa njodzi.
Munyori anotungamirira Omar H. Butt, MD, PhD, murayiridzi wezvokurapa anoona varwere paSiteman Cancer Center paBarnes-Jewish Hospital neWashington University School of Medicine, akati, "Ongororo yedu inoratidza kuti vamwe varwere vanowana CAR-T cell therapy vane kukuvadzwa kusati kwamboonekwa kune maneurons aripo pakutanga, tisati tatanga kugadzirira kurapwa uku. " “Hatizive mabviro ekukuvara uku, asi zvinoita sekunge vanhu vangangove nedambudziko reurotoxic. Tinogona kudzivirira kana kuderedza kuomarara kwemhedzisiro iyi kana tikaziva kuti ndiani ari panjodzi kwavari.
Iprotein yeNfL, chiratidzo chakafara chekukuvara kweuronal, yakashandiswa kuyera kana kuronda kuoma kwehuwandu hwemamiriro etsinga, kusanganisira chirwere cheAlzheimer uye multiple sclerosis.
Maererano nemunyori mukuru pamwe chete naDaniel J. Brennan Purofesa weNeurology Beau M. Ances, MD, PhD, "zviyero zveNfL muropa zviri kushandiswa sechishandiso chekuongorora kushanda kwezvinenge zvichiitwa novel therapeutics for multiple sclerosis." “Tinoshuvira kuita tsvakiridzo yakawanda kuti tione kuti chii chinokonzera kukuvadzwa neuronal muvarwere vegomarara ava. Nekuti Washington University ine dzimwe nyanzvi dzepamusoro muCAR-T cell therapy uye ruzivo rwepamusoro-soro muzvirwere zveurourodegenerative, kubatana kusingaite uku kwakagoneka. Inopa mukana unoshamisa wekuzadza mapundu uye kuunza akasiyana hunyanzvi pamwechete mukuyedza kutsvaga mhinduro inoshungurudza uye kubatsira vanhu.
30 individuals underwent treatment at Cleveland’s Siteman Cancer Center and Case Comprehensive Cancer Center, both of which are affiliated with Case Western Reserve University.
Varwere vasina kuona chero neurotoxic mhedzisiro inogona kusiyaniswa kubva kune avo vakaita izvi zvichienderana neNfL yavo yekutanga nhanho. Kuti vaone kana saizi yakakura yemuenzaniso ichaita kuti vakwanise kuona varwere vari panjodzi yezvinyoro, zvine mwero, kana zvakakomba matambudziko, vaongorori vanotarisira kuenderera mberi nekuongorora data kubva kune vamwe varwere.
Matambudziko anogona kubva pakutemwa nemusoro, kubatwa nepfari, sitiroko, uye kuzvimba kwehuropi kusvika kunetsa kuisa pfungwa pachinhu chimwe, nyaya dzekurangarira, kuvhiringidzika, kutadza kuverenga, uye kutemwa nemusoro. High-dose steroids uye dzimwe nguva immune-modulating marapiro ayo anovavarira kuderedza kuzvimba inzira huru idzo vanachiremba vanorapa matambudziko aya. Sezvo marapiro aya anogona, zvinosiririsa, kukanganisa maitiro ekurwisa gomarara emaseru eCAR-T, vanachiremba vangada kusaashandisa pese pazvinogoneka, nokudaro zvinobatsira zvikuru kuziva kuti ndiani ari panjodzi yekunyanya kukuvadza.
Imwe pikicha ndeyekuti kunyangwe vamwe varwere vaine neurotoxic mhedzisiro uye gare gare kupora kubva kwavari, iyo yakasimudzwa NfL mazinga atovepo uye kazhinji anogara aripo. Izvi zvinoreva kuti nepo NfL mazinga asingareve kuti chii chiri kuitika kukonzera matambudziko evarwere, anoratidza kuti chimwe chinhu chakashata.
Panyaya yekurwara chaiko, "tiri kungoona pamusoro pechando, uye ndiko kwave kunanga kuferefeta kwedu kwakawanda," Butt akadaro. "Tiri kuyedza kunzwisisa zvakanyanya izvo zvakakonzera kugadziridzwa uku. Uye gare gare, kunyange kana zviratidzo zvapera, aya epamusoro NfL mazinga achiripo.
We have a study ongoing at Siteman to see if, in fact, these patients continue to have subtle symptoms in terms of cognitive changes or deficits that persist long term,” added co-senior author Armin Ghobadi, MD, an associate professor of medicine and clinical director of the Center for Gene and Cellular immunotherapy at Washington University School of Medicine and Siteman Cancer Center.
