Idan kana karanta wannan, kai ko watakila ɗaya daga cikin masoyinka yana kan tafiya wanda babu wanda ya taɓa shirin ɗauka-hanyar fuskantar ciwon daji.
Mun fahimci cewa wannan hanyar tana cike da rashin tabbas, tsoro, da lokacin da ake jin kamar duniya ta juye. Amma akwai labari mai daɗi a gare ku, wanda zai iya kawo ƙarshen damuwar ku!
Bari mu yi magana game da wani abu da zai iya kawo haske na bege ga tafiyarku - immunotherapy.
Ya fi magani kawai; haske ne na bege da tunatarwa akai-akai cewa ba kai kaɗai ba, kimiyya yana faɗa da kai.
A cikin wannan shafi, za mu tattauna muhimmiyar rawa ta immunotherapy a cikin maganin lymphoma, wanda ke ba masu ciwon daji sabon fata.
Za mu nuna muku yadda motar t cell therapy magani a Indiya hanya ce mafi wayo kuma mafi inganci fiye da sauran hanyoyin likita. Don haka, tsaya a kusa, kuma bari mu gano fa'idodin ban mamaki na immunotherapy don linzoma tare!
Menene Lymphoma?
Lymphoma wani nau'i ne na ciwon daji wanda ke farawa a cikin tsarin mu na lymphatic, wanda shine muhimmin sashi na tsarin rigakafi.
Wani nau'in farin jini ne wanda ke samuwa a cikin kasusuwa. Wadannan lymphocytes suna yawo a ko'ina cikin jikinmu ta hanyar jini da tsarin lymphatic.
Tsarin lymphatic, wanda ya ƙunshi abubuwa masu mahimmanci irin su ƙwayoyin lymph, suna aiki a matsayin mai tsaro ta hanyar tace ruwan lymph don cire ƙwayoyin waje.
Nau'o'in lymphocytes daban-daban, ciki har da ƙwayoyin B, ƙwayoyin T, da kwayoyin kisa na halitta (NK), suna girma a cikin nodes na lymph don kai farmaki ga kwayoyin cuta da mahara da ke cikin ruwan lymph.
Lymphomas na faruwa ne lokacin da lafiyayyen lymphocytes suka canza zuwa sel masu ciwon daji. Wannan ya raba lymphomas zuwa nau'i uku: lymphomas cell B (mafi yawa), T cell lymphomas, da kuma NK cell lymphomas (kasa da kowa amma mai yiwuwa).
Ko da yake ma'amala da lymphoma yana da wayo sosai, hanyoyin zamani kamar motar t immunotherapy don lymphoma suna ba mu fata da ƙarfafa tsarin rigakafin mu don yin yaƙi da ƙarfi duk da ƙalubalen da yake kawowa.
Nau'in Lymphoma
Lymphoma ya fi shafar yara da matasa kuma ya kasu kashi biyu -
Hodgkin Lymphoma (HL)
Irin wannan nau'in lymphoma yana da alaƙa da kasancewar wani tantanin halitta na musamman da ake kira Reed-Sternberg cell.
Lymphoma na Hodgkin sau da yawa yana farawa a cikin ƙwayoyin lymph kuma zai iya yada zuwa wasu sassan jiki. Yana da ƙarancin kowa fiye da ba Hodgkin lymphoma.
Non-Hodgkin Lymphoma (NHL)
Wannan rukuni ne na lymphomas na kowa kuma daban-daban wanda ya haɗa da nau'i-nau'i daban-daban. Lymphomas wadanda ba Hodgkin ba na iya tasowa daga nau'ikan lymphocytes da yawa kuma suna iya shafar ƙwayoyin lymph, saifa, kasusuwa, da sauran gabobin.
Ta yaya CAR T Don Lymphoma ke Sake rubuta Dokokin Kula da Ciwon daji?
Indiya ta bullo da tsarinta mafi ƙarfi da inganci don taimaka wa mutanen da ke fama da cutar lymphoma. Wannan sabon maganin rigakafi na lymphoma yayi kama da baiwa tsarin garkuwar jikin ku haɓaka mai ƙarfi.
CAR T yana nufin "T-cell na Chimeric Antigen Receptor," wanda zai iya zama mai rikitarwa, amma ita ce hanya mafi kyau don cajin ƙwayoyin mu na rigakafi.
Likitoci suna ɗaukar wasu ƙwayoyin garkuwar jikinmu, mu gyara su a cikin lab don ganewa da kuma kai hari ga ƙwayoyin lymphoma, sannan su sake shigar da su cikin jikinmu don ganowa da kawar da ƙwayoyin cutar kansa.
Bisa ga binciken, CAR T-cell far yana da babban rabo mai yawa, tare da adadi mai yawa na marasa lafiya suna amsawa mai kyau.
Alal misali, a gwaji na asibiti don takamaiman nau'ikan lymphomas, ƙimar amsawa sun wuce 80%, yana nuna babban tasiri akan cutar.
Wannan farfadowa yana da amfani musamman ga marasa lafiya waɗanda ba su amsa da kyau ga daidaitattun hanyoyin kwantar da hankali ba. The farashin motar t cell therapy a Indiya kimanin $ 57,000 ne.
Koyaya, a cikin kwanaki masu zuwa kamfanoni kamar Immuneel da Cellogen za su ƙaddamar da sabon maganin CAR-T wanda zai tashi daga $ 30,000 zuwa $ 40,000.
Ta yaya Immunotherapy Don Ciwon daji na Lymphoma Ya bambanta da Magungunan Al'ada?
To, bari mu karya shi! Jiyya na rigakafi don lymphoma na Hodgkin da lymphoma na Non-Hodgkin suna da babban nasara rates idan aka kwatanta da jiyya na al'ada.
Chemotherapy -
Magani ne mai ƙarfi wanda ke amfani da jijiya ko magungunan baka don tsara tsari da lalata cutar kansa Kwayoyin a ko'ina cikin jiki.
Duk da yake maganin cutar sankara yana da tasiri akan lymphoma, kuma yana iya samun mummunan tasiri akan ƙwayoyin lafiya, yana haifar da mummunan sakamako.
Radiation far
Ana haɗa wannan maganin sau da yawa tare da chemotherapy kuma yana amfani da ƙarfi mai ƙarfi Harkokin X zuwa kai tsaye kai tsaye ga ƙwayoyin lymphoma waɗanda suka taru a cikin ƙwayoyin lymph.
Tushen Kwayoyin Tsari
Ana iya buƙatar dashen ƙwayar ƙwayar ƙwayar ƙwayar cuta, wanda aka fi sani da ƙwayar kasusuwa, tun da chemotherapy da radiation far na iya lalata lafiya. kwayoyin jini da ciwon daji Kwayoyin. Wannan magani yana maye gurbin ƙwayoyin jini masu lafiya don tallafawa farfadowa.
Photopheresis
Wani nau'i ne na photoimmunotherapy wanda ke amfani da haske don kunna tsarin rigakafi a cikin yaki da takamaiman nau'in lymphoma wanda zai iya faruwa ta hanyar dasawa ta cell.
Phototherapy
Phototherapy ya bayyana a matsayin zaɓin magani mai ban sha'awa don farkon-lokacin cutaneous T cell lymphoma. Yana amfani da hasken ultraviolet (UV) don hari da lalata ƙwayoyin cutar kansar fata.
Surgery
Ko da yake ana amfani da tiyata sau da yawa don tantance lymphoma, akwai wasu yanayi wanda tumo kawarwa ta hanyar aikin tiyata ana ganin ya dace.
Duban Kusa da Immunotherapy's Side Effects
Koyi game da illolin immunotherapy a cikin jiyya na lymphoma. Tasirin ya bambanta daga mutum zuwa mutum, dangane da ko yana da immunotherapy don lymphoma na Hodgkin, immunotherapy don lymphoma follicular, ko immunotherapy don babban b cell lymphoma. Duk da haka, wasu daga cikin na yau da kullum immunotherapy ga lymphoma illa kamar haka:
gajiya
Ra'ayin Fata
Alamu Kamar Mura
Nausea da Vomiting
Gudawa ko Maƙarƙashiya
Rashin Ciwa
Jinin Jiki
Dizziness Ko Rudani
ciwon kai
Ƙananan Ƙididdigar Kwayoyin Jini
Fahimtar Nau'in Zaɓin Jiyya na Immunotherapy
Matsayin Immunotherapy a cikin Jiyya na Lymphoma yana da matukar mahimmanci yayin da waɗannan sabbin hanyoyin ke sake fasalin maganin cutar kansa. Bari mu gano yadda waɗannan hanyoyin kwantar da hankali na musamman, daga ƙwayoyin rigakafi zuwa alluran rigakafi, ke canza wasan a yaƙi da ciwon daji.
Magungunan Monoclonal
Monoclonal rigakafi kwayoyin halitta ne da aka halicce su a dakin gwaje-gwaje waɗanda ke yin kwafin ikon tsarin rigakafi na yaƙar ƙwayoyin cutarwa. Suna aiki ta hanyar haɗawa da takamaiman sunadaran da ke saman sel masu ciwon daji.
Wadannan ƙwayoyin rigakafi na iya hana ƙwayoyin cutar kansa girma ba tare da katsewa ba, taimakawa tsarin rigakafi don gano ƙwayoyin cutar kansa don kawar da niyya, ko fara wani tsari wanda ke sa ƙwayoyin cutar kansa su fuskanci halakar kansu. Wannan ingantaccen maganin rigakafi ne na lymphoma B-cell.
Immune Checkpoint Inhibitors
Wannan shine mafi inganci immunotherapy don t cell lymphoma. Masu hana rigakafin rigakafi suna toshe wasu sunadaran akan ƙwayoyin rigakafi ko ƙwayoyin cutar kansa, suna ba da damar tsarin rigakafi don ganewa da kai hari ga ƙwayoyin cutar kansa yadda ya kamata.
A cikin tsarin garkuwar jiki, sel na yau da kullun suna da wurin bincike na furotin wanda ke yin haɗin gwiwa tare da sunadaran a cikin ƙwayoyin T, suna nuna alamun T su daina kai hari.
Kwayoyin cutar daji, a gefe guda, na iya yaudarar tsarin garkuwar jiki don yin kuskuren su ga ƙwayoyin lafiya. Masu hanawa suna shiga tsakani ta hanyar tarwatsa waɗannan nau'ikan sunadaran sunadaran, suna tabbatar da cewa ƙwayoyin T sun gano daidai da ƙaddamar da hari akan ƙwayoyin lymphoma.
Immunotherapy na salula
Immunotherapy na salula shine tsarin gyaran ƙwayoyin rigakafi na majiyyaci (yawanci kwayoyin T) don inganta ikon su na ganowa da kawar da kwayoyin cutar kansa.
CAR T-cell far (Chimeric Antigen Receptor T-cell) sanannen misali ne na rigakafi na salula. A cikin wannan hanya, ƙwayoyin T suna yin aikin injiniya ta hanyar kwayoyin halitta don bayyana mai karɓa wanda ke gane kwayoyin cutar kansa, yana haifar da amsa mai karfi da keɓaɓɓen maganin cutar kansa.
Maganin Ciwon daji
Mai warkewa maganin ciwon daji karfafa tsarin rigakafi don ganewa da yaki da kwayoyin cutar daji. Ba kamar daidaitattun alluran rigakafi ba, waɗanda ke ƙoƙarin hana cututtuka, waɗannan alluran rigakafin suna da nufin warkar da ciwace-ciwacen da ke akwai.
Ana iya ƙirƙira waɗannan alluran rigakafin don kai hari kan takamaiman sunadaran a cikin ƙwayoyin kansa da kuma tada martanin rigakafi daga cutar kansa.
Rayuwar Gaskiya Ta Shafar Jiyya na Immunotherapy
Haɗu da Shawn, jarumi ɗan shekara 29 daga Hong Kong wanda tafiyar kansa ta fara da alamun zazzaɓi, gajiya, da launin fata a cikin Maris 2017.
Shawn ya fara jinya a asibitin Yariman Wales bayan an gano shi m B-lymphocytic cutar sankarar bargo. Bayan nasarar maganin chemotherapy da maganin radiation, ya bayyana ya samu lafiya kuma ya samu lafiya zuwa watan Afrilu.
Duk da haka, jarrabawar kasusuwa a ranar 19 ga Afrilu, 2018, ya gano kashi 10% na ciwon gonorrhea. Fuskantar wannan ƙalubale, ƙwararrun ƙwararrun Hong Kong sun ba da shawarar cewa maganin chemotherapy na gargajiya bazai isa ba kuma sun ba da shawarar maganin CAR-T a matsayin zaɓi mai ban sha'awa.
Daga nan ne Shawn ya yanke shawarar shiga cikin binciken asibiti, yana fuskantar gyare-gyaren kwayoyin halittar T-cell ɗinsa don ƙirƙirar “kwayoyin T-cell na chimeric antigen (CAR). Waɗannan sel na musamman an yi su ne don keɓance ƙwayoyin cutar kansa musamman.
A ranar 6 ga Mayu, Shawn ya sake yin wani zagaye na chemotherapy. A ranar 11 ga Mayu, ya sami jiko na ƙwayoyin CD19 CAR T. Cikakkun rahotanni sun bayyana ba a sami wasu abubuwan da ba su dace ba a cikin daidaitawar CSF, cytometry mai gudana, ilimin halittar jikin kasusuwa, gwajin DNA, ko rahoton CAR-T bayan makonni huɗu na kusancin sa ido da sarrafa tasirin sakamako.
Shawn ya sami cikakkiyar murmurewa, yana nuna babban nasara a yaƙin da ya yi da kansa. Bayan irin wannan farfadowa na ban mamaki, Shawn yana shirye don mataki na gaba na tafiyarsa-bargon kashi da dashen jini lokacin da ya dawo Hong Kong.
Labarin sa na motsa jiki yana ba da haske game da rawar juyin juya hali na Immunotherapy a cikin Jiyya na Lymphoma da kuma shawo kan cutar mai kisa kamar kansa.
Mu Kayar da Cutar Cancer Tare!
Yayin da muke ƙaddamar da bincikenmu a cikin duniyar immunotherapy don maganin lymphoma, bari mu riƙe wani abu mai mahimmanci - bege.
Yi la'akari da immunotherapy ko CAR-T Cell Therapy a matsayin babban jarumi akan ƙungiyar yaƙi da kansa, samar da sabuwar hanya zuwa waɗannan lokutan wahala.
Kowace nasara story, kowane mataki na ci gaba a kimiyya, kamar haske ne mai haske a cikin tafiya da ciwon daji. Idan kai ko wani da ka sani yana cikin wannan tafiya, ku tuna cewa kun fi ƙarfin tunaninku, kuma duk matakin da kuka ɗauka don wannan maganin nasara ce.
Don haka mu fuskanci shi tare tunda bege shine makamin da yafi karfin mu wajen yakar cutar daji. Ba ku kadai ba, kuma hanyar da ke gaba tana cike da yuwuwar samun haske, koshin lafiya gobe. Tuntuɓe mu a yau don canza wannan ƙalubale mai ƙalubale zuwa gobe mai haske!
