Mai neman sauyi CAR T Magungunan Kwayoyin cuta yana canza yanayin yadda muke magance ciwon daji, yana mai da shi mafi sirri da ƙarfi. Wannan sabuwar maganin yana amfani da ƙwayoyin rigakafi na majiyyaci kuma yana canza su ta hanyar kwayoyin halitta don kai hari da lalata ƙwayoyin cutar kansa tare da ingantaccen daidaito. Yana jagorantar hanya zuwa haske, mafi koshin lafiya gobe!
Shin kun taɓa yin tunani game da iyawar jikinmu masu ban mamaki?
Idan ba haka ba, lokaci ya yi da za a sami ilimi kan wannan muhimmin batu.
To, idan na gaya muku cewa ƙwayoyinku na iya yin aiki kamar jarumawa, suna yaƙar cututtuka masu mutuwa kamar kansa da daidaiton da ba ya kama?
Yana iya zama kamar almara kimiyya. Amma kace me? Wannan ƙarfin juyin juya hali yana yin raƙuman ruwa a hankali, kuma ana kiransa CAR T Magungunan Kwayoyin cuta!
Muna gayyatar ku don fahimtar cikakkun bayanai masu rikitarwa na CAR T Cell aiwatar da mataki-mataki, gami da yadda ake noman waɗannan ƙwayoyin sel, gyara su, da sake dawowa cikin jikin ku don yaƙar cutar kansa.
Don haka, ko kuna sha'awar sanin wannan maganin ko kuma wanda ya kamu da cutar sankara mai kisa, ci gaba da karanta wannan jagorar don fahimtar ikon wannan kyakkyawan magani.
Fahimtar CAR T Cell Therapy
Chimeric Antigen Receptor (CAR) T-cell far babban ci gaba ne a cikin maganin ciwon daji wanda ya haɓaka a cikin 'yan shekarun nan, yana kawo sabon bege da yuwuwar.
Don fahimtar CAR T-cell far, bari mu yi la'akari da tsarin garkuwar jikin ku a matsayin jami'in tsaro mai aiki da ke sintiri a jikin ku don masu kutse, gami da ciwon daji.
Manyan ƴan wasa a cikin wannan tsarin tsaro sune T-cells-fararen jini sanye take da masu karɓa waɗanda ke aiki azaman tsarin sa ido na tsarin rigakafi. Waɗannan masu karɓa suna gano barazanar kamar kansa ta hanyar kai hari ga sunadaran da aka sani da antigens a saman sel masu kutse.
Duk da haka, ƙwayoyin kansa suna da kyau wajen ɓarna kansu don su iya ɓoye daga ƙwayoyin T. CAR T cell Tsarin jiyya yana ƙoƙarin shawo kan wannan ƙalubale ta hanyar juya ƙwayoyin T-cell na yau da kullun zuwa abubuwan yaƙi da cutar kansa.
Wannan tsari ya ƙunshi gyare-gyaren kwayoyin halittar T-cell don bayyana Chimeric Antigen Receptors (CARs), waɗanda ke aiki azaman makamai masu ƙarfi, ƙyale ƙwayoyin T su gane da kuma kai hari ga ƙwayoyin kansa yadda ya kamata.
Za ku yi farin cikin sanin cewa kusan kashi 70% na masu fama da cutar kansa suna amsa da kyau ga cutar CAR T jiyya ta kwayar halitta a Indiya daidai.
Duba Wannan: Matsayin Immunotherapy A cikin Jiyya na Lymphoma - CancerFax
Shin Wannan Sabon Maganin Ciwon Sankara Zai Iya araha?
Labari mai dadi ga duk masu ciwon daji a can! Mumbai mai tushe Immunoact sabon maganin ciwon daji, NexCAR19, samu yarda.
don cutar sankarar bargo da marasa lafiya na lymphoma waɗanda ba su amsa wasu jiyya ba. The Farashin CAR T cell far a Indiya kusan USD 57,000, wanda ya fi arha fiye da sauran wurare da yawa.
Nufin wannan India na iya zama ɗaya daga cikin wurare mafi kyau kuma mafi araha don wannan ci gaban maganin ciwon daji, yana ba da bege ga waɗanda suke buƙatarsa.
Nau'in Ciwon daji Da Aka Yi Magance Tare da Tsarin Kwayoyin CAR T
Wannan maganin ciwon daji ya fi tasiri ga masu ciwon daji waɗanda basu amsa maganin chemotherapy da sauran maganin ciwon daji ba. Wannan magani ya nuna wasu sakamako masu ban sha'awa a cikin kula da nau'o'in iri daban-daban cutar kansa. Anan akwai jerin wasu aikace-aikacen jiyya na t cell gama gari:
Multiye Myeloma
Multiple myeloma wani nau'in ciwon daji ne wanda da farko ke kai hari ga ƙwayoyin plasma, waɗanda sune mahimman abubuwan tsarin rigakafi da ke da alhakin samar da ƙwayoyin cuta.
A cikin wannan yanayin, ƙwayoyin plasma marasa al'ada suna karuwa ba tare da katsewa ba, suna tattara ƙwayoyin al'ada a cikin kasusuwa. Immunotherapy da kuma dasawa cell shine mafi tasiri Maganin myeloma da yawa a Indiya.
Kwayoyin B-Cute Lymphoblastic Leukemia
B-cell m lymphoblastic cutar sankarar bargo (B-ALL) wani nau'in ciwon daji ne wanda ke tasiri ga lymphocytes B marasa balagagge, takamaiman rukuni na fararen jini, yayin haɓakarsu a cikin bargo.
Maimakon girma zuwa lafiyayyen ƙwayoyin farin jini, waɗannan ƙwayoyin da ba su balaga ba sun zama marasa al'ada kuma suna haɓaka cikin sauri, suna cunkoso na yau da kullun. Don magance wannan cuta, likitoci sukan yi amfani da haɗin chemotherapy da dashen kasusuwa.
B-cell Non-Hodgkin Lymphoma
Akwai nau'ikan nau'ikan B-cell da yawa ba Hodgkin lymphoma (B-NHL), ciki har da lymphoma mai girma B-cell (DLBCL), lymphoma follicular tare da DLBCL, da kuma babban darajar B-cell lymphoma.
Wadannan cututtukan daji suna fitowa ne daga B lymphocytes, nau'in kwayar jinin jini, kuma an rarraba su bisa ga halaye na musamman. Mai ba da lafiyar ku na iya magance wannan yanayin tare da chemotherapy, dashen kwayoyin halitta, da ƙwayoyin rigakafi na monoclonal.
Lymphoma na Mantle Cell
Mantle cell lymphoma wani nau'i ne na lymphoma wanda ba Hodgkin ba wanda ya samo asali a cikin lymphocytes B. Wannan musamman nau'i na linzoma yana da saurin haɓakar ƙwayoyin cutar kansa, galibi suna mamaye ƙwayoyin ƙwayoyin lymphoid daban-daban. Sau da yawa ana bi da lymphoma na Mantle tare da haɗin chemotherapy da kuma dashen sel mai tushe.
Tsarin Mataki-Ta-Taki Don CAR T Cell Therapy
1. Da farko, mai kula da lafiyar ku yana sanya ƙaramin bututu (catheter) zuwa cikin jijiya a wuyanku ko ƙarƙashin ƙashin wuyanku.
2. Suna haɗa catheter zuwa na'ura don tsari mai suna leukapheresis. Wannan injin yana sarrafa jinin ku, yana fitar da fararen jini kuma yana mayar da jajayen ƙwayoyin jini da plasma zuwa jikin ku.
3. Bayan haka, an ƙaddamar da ƙwayar cuta mara aiki don ba da sabbin umarnin kwayoyin halitta ga ƙwayoyin T-ka.
4. Kwayoyin T-ku sun fara samar da masu karɓan antigen na chimeric (CAR) da ƙwayoyin cuta masu ɗauke da sabbin ka'idojin kwayoyin halitta.
5. Masu karɓar CAR suna ƙarewa a saman sassan T-cell ɗin ku, yayin da kwayoyin halitta suka kasance a ciki, suna ba da sigina don kiyaye T-cell ɗin ku.
6. Ana ƙarfafa ƙananan ƙwayoyin CAR T-cell don haɓaka da girma har sai an sami isashen cutar kansa da kyau. Ana daskarar da waɗannan ƙwayoyin kuma a ajiye su a cikin injin daskarewa har sai an buƙata.
7. Kafin karbar sabbin kwayoyin halitta, za a sha maganin chemotherapy don hana tsarin garkuwar jikin ku daga kin su.
8. Bayan chemotherapy, za ku sami sabbin ƙwayoyin cuta ta hanyar jiko, ko dai a asibiti na kwanaki da yawa ko, a wasu yanayi, ba tare da tsayawa a asibiti ba, ƙarƙashin kulawar ƙungiyar kula da lafiyar ku.
9. Da zarar an shiga cikin jinin ku, masu karɓar CAR T-cell suna gane kuma suna ɗaure zuwa antigens (proteins) akan ƙwayoyin ciwon daji.
10. Kwayoyin T-CAR ɗin ku sannan su ninka kuma su fara kashe ƙwayoyin cutar kansa da daidaito. Kwayoyin T-CAR ɗin ku suna ci gaba da girma kuma suna neman sabbin ƙwayoyin cuta tare da antigen da aka yi niyya don tabbatar da rigakafin cutar kansa na dogon lokaci.
CAR T Kwayoyin Farfadowar Kwayoyin Halitta waɗanda Dole ne ku sani
Ciwon Sakin Cytokine
Wannan sakamako ne na gama gari inda ƙwayoyin CAR T-cells ke haifar da sakin cytokines, wanda ke haifar da alamu kamar zazzabi, ƙarancin jini, da wahalar numfashi.
Gubar Neurological
Wasu mutane na iya samun rudani, rikice-rikice, ko wasu al'amurran da suka shafi jijiya saboda tasirin CAR T-cell far akan tsarin kulawa na tsakiya.
Ciwon Marrow Kashi
Maganin CAR T-cell na iya iyakance samar da ƙwayoyin jini na ɗan lokaci a cikin kasusuwa, wanda ke haifar da ƙananan matakan jajayen ƙwayoyin jini, ƙwayoyin jinin jini, da platelets.
Cututtuka
Marasa lafiya tare da raunin tsarin rigakafi, musamman a lokacin farko bayan jiyya, sun fi kamuwa da cututtuka.
Final Zamantakewa
Yayin da muke kammala bincikenmu na CAR T Cell Process, bari mu ɗauka tare da mu ingantaccen fahimtar cewa kimiyya tana buɗe sabbin hanyoyin yaƙi da cutar kansa.
Hanyar tantanin halitta ta CAR T ya fi magani kawai; hujja ce ta ban mamaki ci gaban da ake samu a cikin keɓaɓɓen maganin cutar kansa.
Don haka, ga duk masu jajircewa wajen fuskantar wannan ƙalubale, ku sani cewa duniyar likitanci tana bunƙasa, kuma kowane ci gaba mataki ne na samun kyakkyawar makoma mai haske da lafiya. Muna yi muku fatan samun lafiya cikin sauri da makoma lafiya!
