Tumor-infiltrating lymphocyte (TIL) far
Hanyar juyin juya hali a cikin maganin ciwon daji.
Kuna son yin rajista a cikin wannan ci gaban maganin ciwon daji?
Tumor-infiltrating lymphocyte far (TIL) hanya ce mai ban sha'awa a cikin maganin ciwon daji. Ya ƙunshi cire ƙwayoyin rigakafi, musamman ƙwayoyin T, daga ƙwayar ƙwayar cuta ta majiyyaci. Wadannan ƙwayoyin T suna girma kuma suna ninka su a cikin dakin gwaje-gwaje kafin a dawo da su cikin jikin majiyyaci. Manufar ita ce haɓaka ikon tsarin rigakafi don ganewa da kai hari ga ƙwayoyin cutar kansa yadda ya kamata. Ana ɗaukar maganin TIL a matsayin wani nau'i na canja wurin kwayar halitta, yana ba da damar maganin rigakafi na majiyyaci akan ƙari. Wannan keɓaɓɓen immunotherapy yana riƙe da yuwuwar magance cututtukan daji daban-daban kuma yanki ne mai aiki na bincike da haɓaka asibiti a cikin ilimin oncology.
Fabrairu 2024: Yanzu ana ba da wani sabon salon immunotherapy ga marasa lafiya tare da ci-gaba melanoma. An san shi da Maganin TIL, wanda ke tsaye ga ƙwayar ƙwayar ƙwayar cuta ta lymphocyte. Allurar jiyya na T-cell na lokaci ɗaya tana ɗaukar ƙwayoyin rigakafi na majiyyaci don yaƙar kansa. Wannan shine karo na farko da maganin tantanin halitta don ingantaccen ciwace-ciwace ya sami amincewar FDA.
Bayanan bincike na asibiti sun nuna cewa maganin na lokaci ɗaya yana da kashi 36% na amsawa a cikin mutane tare da melanoma na metastatic, wanda shine kyakkyawan sakamako idan aka yi la'akari da cewa an gwada wannan maganin a cikin marasa lafiya waɗanda rashin lafiya ya tsananta bayan sun sha nau'in rigakafi daban-daban. Har ila yau, marasa lafiya sun sami amsa na dogon lokaci, suna da kyau fiye da shekaru biyu.
Tumor-infiltrating lymphocyte (TIL) far wani yanke shawara ne na rigakafi da ke amfani da tsarin garkuwar jiki don yaƙar ciwon daji. Wannan sabon jiyya an lasafta shi azaman canja wurin kwayar halitta (ACT), wanda a cikinsa ake cire ƙwayoyin rigakafi na majiyyaci, sarrafa su, ko haɓaka su a cikin dakin gwaje-gwaje kafin a sake shigar da su cikin majiyyaci don manufa da kawar da ƙwayoyin cutar kansa.
Yaya TIL far ke aiki?
Maganin TIL ya haɗa da tattara T-lymphocytes (T-cells) daga ƙwayar ƙwayar cuta da aka cire. Sannan ana haɓaka waɗannan ƙwayoyin a cikin dakin gwaje-gwaje don haɓaka ƙarfinsu na yaƙi da cutar kansa ta hanyar zaɓi da haɓaka mafi ƙarfi T-cell. Ana sake shigar da waɗannan ƙwayoyin a cikin majiyyaci ta hanyar jiko bayan shigar da chemotherapy. Sabbin kwatankwacin T-cell suna tafiya cikin jiki, suna kai hari tare da kashe ƙwayoyin ƙari.
Menene tsarin maganin TIL?
Tumor-infiltrating lymphocyte (TIL) far wani nau'i ne na juyin juya hali na immunotherapy wanda ke amfani da tsarin rigakafi na majiyyaci don kai hari ga kansa sosai. Anan ga cikakken taƙaitaccen tsarin da ke cikin maganin TIL dangane da bayanan da aka samo daga tushe da yawa:
Cirewar T-lymphocytes: Maganin TIL yana farawa da girbin ƙwayoyin T daga ƙwayar cuta da aka cire ta hanyar tiyata. Waɗannan ƙwayoyin T sune mahimman abubuwan da ke cikin tsarin rigakafi, ganowa da kawar da ƙwayoyin cutar kansa.
Haɓaka Laboratory: Sannan ana jigilar kwayoyin T-cell zuwa dakin gwaje-gwaje, inda za'a gyara su da inganta su don inganta karfinsu na yakar cutar daji. Wannan hanya ta ƙunshi ɗaukar mafi yawan ƙwayoyin T-kwayoyin da kuma yin kwafin su don gina tsarin rigakafi mai ƙarfi.
Jiko Komawa cikin Mara lafiya: Da zarar an fadada TILs yadda ya kamata zuwa biliyoyin sel, an sake dawo da su cikin majiyyaci ta jiko. An tsara waɗannan manyan ƙwayoyin T-cell don ganowa da kai hari kan ƙwayoyin cutar kansa yayin da suke kare lafiyayyen ƙwayoyin cuta.
Induction Chemotherapy: Kafin jiko na TILs, marasa lafiya sukan sami hanyar maganin chemotherapy na mako guda don ba da damar sabbin ƙwayoyin T-da aka ƙaddamar da su cikin nasara cikin jiki. Wannan lokaci yana da mahimmanci don haɓaka yuwuwar warkewar jiyya ta TIL.
Tsawon Jiyya: Ba kamar sauran magungunan kansar da ke buƙatar ci gaba da kulawa ba, ana yin maganin TIL yawanci sau ɗaya kawai. Duk da haka, idan marasa lafiya a baya sun amfana daga maganin TIL kuma suna buƙatar ƙarin magani, ana iya yin la'akari da zagaye na biyu na farfadowa.
Maganin TIL gabaɗaya yana da ƙananan sakamako mara kyau, tare da alamu akai-akai waɗanda suka haɗa da zazzabi, sanyi, da ƙarancin numfashi. Wadannan illolin ana danganta su akai-akai ga wasu sassa na tsarin jiyya maimakon ƙwayoyin TIL da kansu.
Maganin TIL ya bambanta da CAR-T cell far a cikin cewa yana girma TILs kai tsaye daga ƙari maimakon canza su ta hanyar kwayoyin halitta. Bugu da ƙari, samfuran TIL sune polyclonal, gami da clones da yawa na T-cell waɗanda ke da ikon yin niyya da yawa na antigens.
Don taƙaitawa, maganin TIL hanya ce mai ban sha'awa don maganin ciwon daji tun da yake yana amfani da tsarin rigakafi na mara lafiya da kyau don yaƙar kansa. Wannan sabon magani yana da babbar dama don magance cututtuka iri-iri kuma yana ba da sabon bege ga marasa lafiya waɗanda ba su amsa maganin rigakafi na gargajiya ba.
Kuna so karanta: TIL therapy a kasar Sin
Ci gaba da Amfani da maganin TIL
Dokta Steven Rosenberg ya sami nasarar magance cutar ta'addanci ta linzamin kwamfuta tare da TILs mai sarrafa kansa a ƙarshen 1980s, lokacin da ya fara haɓaka maganin TIL. Tun daga wannan lokacin, maganin TIL ya ci gaba sosai, yana nuna tasiri sosai a cikin takamaiman ciwace-ciwacen ciwace-ciwace, musamman melanoma, kansar mahaifa, da kansar launi.
Grit Biotechnology, mai hedkwata a Shanghai, ya sami dala miliyan 60 a cikin kudade na Series B don ciyar da ci gaban ƴan takararta na TIL, tare da fifikon farko kan cutar sankarau, mahaifa, da ciwon huhu. Waɗannan ƙoƙarce-ƙoƙarce sun yi daidai da tsarin duniya a cikin jiyya na TIL, wanda galibi yana haɗa jiyya tare da sauran magungunan rigakafi, kamar wuraren bincike na rigakafi.
Nazarin kwanan nan sun jaddada cewa abun da ke ciki da wuri na TILs a cikin ciwace-ciwacen daji sune mahimman abubuwan da suka shafi tsinkaya da sakamakon magani. Fahimtar ƙaƙƙarfan alaƙar da ke tsakanin TILs da ƙananan ƙwayoyin cuta yana da mahimmanci don haɓaka maganin TIL wanda aka keɓance da takamaiman nau'ikan ƙari da kuma daidaita rarraba marasa lafiya.
Yaya maganin TIL ya bambanta da immunotherapy?
Bambance-bambance Tsakanin TIL Therapy da Sauran Nau'in Immunotherapy
Maganin lymphocyte na Tumor-infiltrating (TIL) ya fice daga sauran fasahohin immunotherapy saboda bambancin kaddarorinsa da hanyoyinsa. Anan ga manyan bambance-bambance tsakanin jiyya na TIL da sauran nau'ikan rigakafi, dangane da bayanan da aka samu daga tushe masu inganci:
1. Tushen Cell da Gyara: – Maganin TIL shine tsarin tattara T-cell kai tsaye daga ƙwayar cuta da aka cire yayin tiyata. Ana shuka waɗannan ƙwayoyin a cikin dakin gwaje-gwaje ba tare da sarrafa kwayoyin halitta ba, wanda ke inganta ƙarfin su na halitta don kai hari ga kwayoyin cutar kansa.
CAR-T Cell Therapy: Sabanin haka, CAR-T cell far reprograms a majiyyaci T-cell a cikin dakin gwaje-gwaje don gane takamaiman sunadaran a kan ciwon daji Kwayoyin. Ana sake dawo da waɗannan sel ɗin da aka gyara ta hanyar majiyyaci don yaƙar ƙwayoyin cutar kansa.
2. Nau'in Ciwon Kansa: Maganin TIL ya kasance mai fa'ida wajen magance tafsirin ciwace-ciwacen daji kamar kansa da wuyansa squamous cell carcinoma, melanoma, kansar huhu, da kuma cututtukan mata. Yana da tasiri musamman ga malignancies da suka yada zuwa wasu yankuna na jiki.
CAR-T Kwayoyin Farfadowa: Ana amfani da maganin tantanin halitta na CAR-T gabaɗaya don magance cututtukan jini kamar cutar sankarar bargo da lymphoma ta hanyar niyya takamaiman alamomi akan ƙwayoyin kansa. Maganin TIL, a gefe guda, na iya zama mafi tasiri a kan ciwace-ciwacen ciwace-ciwace saboda yana iya gano nau'ikan alamomin ƙari.
3. Tsarin Aiki: TILs sune ƙwayoyin rigakafi da ke faruwa a zahiri waɗanda ke shiga ciwace-ciwacen daji kuma daga baya an faɗaɗa su a cikin lab kafin a mayar da su jikin majiyyaci. Waɗannan sel sun yi niyya ga nau'ikan antigens na ƙari da aka gani a cikin ciwace-ciwacen ƙwayoyi.
CAR-T Cell Therapy: CAR-T cells are designed to express chimeric antigen receptors that specifically detect antigens on cancer cells. This therapy is extremely specific to recognized antigens found in blood cancer cells.
4. Tsawon Jiyya da Tasirinsa: -TIL far yawanci ana gudanarwa sau ɗaya, tare da marasa lafiya suna karɓar chemotherapy induction kafin jiko TIL. Yawanci, illolin maganin TIL ba su da kyau kuma akai-akai suna fitowa daga wasu abubuwan tsarin jiyya maimakon ƙwayoyin TIL da kansu.
CAR-T Cell Therapy: CAR-T cell far na iya buƙatar jiko da yawa kuma zai iya haifar da mummunar tasiri irin su ciwon saki na cytokine da neurotoxicity saboda saurin haɓakar amsawar rigakafi.
A taƙaice, maganin TIL da CAR-T cell far duka biyun maganin rigakafi ne na canja wurin tantanin halitta, duk da haka, sun bambanta sosai dangane da tushen ƙwayoyin cuta, nau'in ciwon daji, tsarin aiki, da kuma illa masu alaƙa. Maganin TIL wata hanya ce mai yuwuwar maganin cutar kansa saboda faffadan aikace-aikacen sa game da ciwace-ciwacen ciwace-ciwacen daji da kuma dogaro da martanin rigakafin da ke akwai.
Kuna so karanta: CAR T-Cell far a China
Cututtuka yadda ya kamata tare da maganin TIL
- Ciwon kai & wuya squamous cell carcinoma
- Melanoma
- Ciwon daji na huhu
- Ciwon daji na Genitourinary
- Wasu malignancies
Idan an gano ku tare da melanoma, ko da melanoma ɗinku ya kasance mai mahimmanci ko ya yada, akwai bege. Sabbin jiyya na ci gaba suna sa cutar da melanoma ta ci gaba da rayuwa. Ɗayan magani mafi inganci shine ƙwayar cuta infiltrating lymphocyte (TIL) immunotherapy.
Menene illolin maganin TIL?
Yayin da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta na iya haifar da mummunar tasiri.
Anan ga cikakken bayanin tasirin mummunan tasirin da ke da alaƙa da maganin TIL dangane da bayanai daga tushe masu inganci:
1. Tasirin Gaggawa:
-Zazzabi da sanyi. Marasa lafiya na iya kamuwa da zazzaɓi mai zafi da sanyi akan jiko TIL.
– Tashin zuciya da Rage Ciwon Ciki: Wasu mutane na iya fuskantar tashin zuciya da raguwar sha’awa bayan maganin TIL.
– Alamomin Jijiya: Ciwon kai, juwa, da sauran matsalolin tsarin jijiya na iya faruwa.
– Gajiya: Marasa lafiya na iya samun matsananciyar gajiya da rauni sakamakon maganin.
– Riƙewar Ruwa: Jiki na iya tara ruwa, yana haifar da kumburi.
2. Abubuwan da suka shafi Chemotherapy:
-Ƙarancin Ƙididdigar Jini: Chemotherapy kafin jiko TIL na iya haifar da ƙananan ƙididdiga na jini, buƙatar ƙarin jini.
Kamuwa da cuta: Rashin tsarin garkuwar jiki mai rauni yayin chemotherapy yana ƙara saurin kamuwa da cututtuka.
-Rashin gashi: Wasu mutane na iya samun raguwar gashi a sakamakon yanayin gyaran gashi.
– Ciwon baki: Chemotherapy na iya haifar da ciwon baki.
3. Kulawa na Tsawon Lokaci:
- Ƙungiya mai yawa na likitocin oncologists, ma'aikatan jinya, da sauran likitoci suna sa ido sosai ga marasa lafiya da ke fama da maganin TIL don matsalolin matsalolin.
– Alƙawuran bin diddigin sun haɗa da sa ido kan ƙidayar jini, duba matsalolin, da yin sikanin hoto don tantance martanin ƙari.
4. Dabarun Gudanarwa:
An rage tasirin maganin TIL tare da kulawa na yau da kullun da kulawa bayan jiyya.
– Likitocin likitanci suna ba da cikakkiyar shawara kan yadda ake gudanar da illa da rikitarwa.
5. Maganin TIL ya bambanta da CAR-T cell far domin yana amfani da kwayoyin halitta T-cellun da aka dauka daga ciwace-ciwacen daji, maimakon canza su ta hanyar kwayoyin halitta a cikin dakin gwaje-gwaje. Abubuwan da ba su da kyau na maganin TIL ana danganta su akai-akai ga sauran abubuwan da ke cikin tsarin jiyya maimakon ƙwayoyin TIL da kansu.
A ƙarshe, yayin da maganin TIL yana da babban alƙawari don maganin ciwon daji, dole ne marasa lafiya su tuna da mummunan tasirin wannan sabon dabarun rigakafi. Sa ido kusa da kwararrun kiwon lafiya da kulawa ga jagororin kulawa bayan jiyya suna da mahimmanci don samun nasarar sarrafa waɗannan illolin.
Menene farashin maganin TIL?
Kudin maganin Tumor-Infiltrating Lymphocyte (TIL). ya bambanta dangane da adadin ma'auni. Anan ga taƙaitawar farashin da aka ƙera masu alaƙa da maganin TIL dangane da bayanan da aka samu daga tushe masu inganci:
1. Tsabar kudi:
Ana dubawa: Binciken jiki, gwaje-gwajen jini, da shawarwari yawanci tsadar kuɗi $ 3000.
Ware TILs: Wannan lokaci yana buƙatar tiyata, kwanakin asibiti, da tuntuɓar juna, kuma ana kashe matsakaicin $ 4000 USD.
Ƙirƙirar TIL: Kudin samarwa ya bambanta tsakanin $ 40,000 da $ 60,000, ya danganta da adadin abubuwan samarwa a kowace shekara (majinyata 10 ko 5).
2. Kiyasta Jimlar Kudin: Ƙididdigar farko don kula da majiyyaci ɗaya tare da maganin TIL yana kusa $ 65,000.
A ƙasashe kamar Amurka, kiyasin farashin maganin TIL ya tashi daga $97,600 zuwa $168,440 ga kowane majiyyaci.
Ga Kanada da Burtaniya, farashin farashi shine C$89,072-C$116,295 da £32,945-£60,608, bi da bi.
Dangane da ƙwarewar haƙuri na yanzu da bayanai, Til far zai kashe kusan $ 125,000 a Isra'ila da wani abu tsakanin $ 60-125,000 USD a China. Farashin maganin TIL ya bambanta sosai tare da nau'in da matakin ciwon daji. Kamar yadda wannan maganin har yanzu yana cikin matakin gwaji na asibiti, ƙayyadaddun ƙimar ƙima kusan ba zai yiwu ba.
3. Abubuwan Da Suke Taimakawa Farashin: - TIL farashin magani yana tasiri ta hanyar samarwa da gudanarwa.
- Gina kayan aikin masana'antu da ƙwarewa a cikin maganin tantanin halitta na iya yin tasiri akan farashin gabaɗaya.
4. Tasirin Kuɗi: - TIL far yana da tsada-tasiri idan aka kwatanta da sauran jiyya kamar ipilimumab.
5. Samuwar da Matsalolin Tsara: - Ana ba da maganin TIL ne kawai a cibiyoyi na musamman a duk duniya ta hanyar gwaji na asibiti ko shirye-shiryen samun dama da wuri saboda ƙayyadaddun tsari da masana'antu.
6. Gudanar da Tasirin Side: – Abubuwan da ke tattare da maganin TIL sun haɗa da zazzabi, sanyi, tashin zuciya, amai, gudawa, da gajiya. Kwararrun kiwon lafiya suna kimanta waɗannan illolin a kai a kai a duk tsawon jiyya.
A ƙarshe, yayin da Tumor-Infiltrating Lymphocyte (TIL) far ke nuna yiwuwar maganin ciwon daji, yana da tsada mai yawa wanda ya bambanta dangane da wuri da hanyoyin magani. Kusa da saka idanu akan illar illa da kulawar da ta dace sune mahimman abubuwan da ke cikin dukkan tsarin jiyya.
Ci gaba da bincike da hangen nesa na gaba
Yayin da ake ɗaukar maganin TIL a halin yanzu a matsayin gwaji, masu bincike suna binciken fa'idarsa a cikin nau'ikan ciwon daji daban-daban. Adadin nasarar maganin, musamman a misalan melanoma, ya ingiza ƙarin bincike kan yuwuwar amfani da shi don ɗimbin cututtuka. Masu bincike kuma suna binciken yiwuwar adana ƙwayoyin TIL don amfani da su daga baya azaman "saman" magani idan ciwon daji ya dawo.
Don taƙaitawa, maganin TIL wani gagarumin ci gaba ne a cikin maganin ciwon daji, yana ba da sabon bege ga marasa lafiya waɗanda ba su amsa maganin rigakafi na gargajiya ba. Wannan maganin yana da babbar dama ga makomar ciwon daji saboda ƙarfinsa don samun nasarar ci gaba da kawar da kwayoyin cutar kansa ta hanyar amfani da tsarin garkuwar jiki.