Immunotherapy-ga unugyada NK ee Hindiya
Immunotherapy-ga unugyada NK ee Hindiya waxaa bixiya shirkadaha daweynta unugga qaarkood iyo isbitaallada hadda. Immunotherapy-ga unugyada NK ee loogu talagalay daaweynta kansarka kakan ee soo noqnoqda iyo kuwa kakan ayaa maalinba maalinta ka dambaysa caan ku ah. Bukaanno aad iyo aad u badan ayaa hadda u socda maalmo daawaynta difaaca jirka. Daaweynta unugyada NK waxaa lagu ogaaday inay aad waxtar u leedahay marxaladda dambe ee daaweynta kansarka. Markaa bukaanada galay heerka u dambeeya ee kansarka waxay isku dayi karaan daawayntan. Daawaynta unugyada NK hadda waa laga helayaa gudaha Hindiya. Ma ogtahay faahfaahinta daawaynta iyo kharashka naga soo wac + 91 96 1588 1588 ama warqad u qor kansarfax@gmail.com.
Unugyada difaaca jirka
Kumanaan sano oo horumar ah ka dib, jidhka bini'aadamka wuxuu sameeyay nidaam difaac oo casri ah, wuxuu aasaasay legion awood leh oo difaaca, wuxuu kaydiyaa tiro badan oo askar ah oo caan ah, mar walbana wuxuu naga ilaaliyaa weerarka kansarka. Dhuuxa lafuhu waa saldhigga difaaca jirka. Halkan, unugyada tarma ee hematopoietic waxay u kala soocaan dagaalyahannada difaaca ee kala duwan oo leh hawlo kala duwan. Waxay leeyihiin dhul ciidan oo u gaar ah iyo waajibaad shaqo. Waqtigan xaadirka ah, saddexda ciidan ee habka difaaca jirka iyo kuwa hoos yimaada waa kuwan.
1. Core Corps: Lymphocytes
T-lymphocytes, lymphocytes-ku-tiirsan thymus, waa lymphocytes waaweyn ee dhiigga iyo dib-u-wareejinta
B-lymphocytes: Unugyada ka soo baxa bursada ama xubinteeda u dhiganta (dhuuxa lafta). Waxay u kala saari karaan unugyada balasmaha ee soo saara difaaca jirka marka ay kiciyaan antigen.
Unugyada NK, unugyada LAK uma baahna saameyn dil ah oo dareen-celin leh.
2. Legion Auxiliary: Antigen Presenting Cell
Monocyte-makrophage phagocytosis iyo saamaynta dilka, antigen-ka TD ee jooga, bilaw jawaab celinta difaaca, saamaynta buro-hortagga, qarsoodiga dhexdhexaadiyaha noolaha firfircoon
Unugyada DC waa koox unugyo kala duwan oo leh kuwa ugu xoogga badan antigen soo bandhigida shaqada, waana unugyada soo bandhiga antigen-ka buuxa ee firfircooni kara unugyada asalka ah ee T.
3.Leions unugyada difaaca jirka
Neutrophils, eosinophils / basophils iyo unugyada masska, platelets, unugyada dhiigga cas.
Waa maxay unugyada NK?
Unugyada Whistler-NK ee habka difaaca jirka
Dagaalka difaaca jidhkeenu waxa uu la mid yahay dagaalka cadawga ka soo horjeeda ee lagu muujiyay filimka. Waxay u baahan tahay saddexda ciidan inay si cad u qaybsadaan hawlahooda, dejiyaan qorshe dagaal oo adag, oo ay iska kaashadaan sidii cadowga loo baabi'in lahaa.
Dagaalka ka dhanka ah unugyada kansarka, unugyada NK ayaa ah kuwa ugu cabsida badan "foorayaasha".
It not only bears the brunt, it is the first to reach the buro microenvironment to directly kill cancer cells, and it also sounds the horn of war, secretes secret weapon chemokines, and recruits dendritic cells (CD103 + DC), which is equivalent to telling other immune legions in the body Come and cooperate. The activated dendritic cells then carry tumor antigens to the lymph nodes, presenting the characteristics of the cancer cells to the killer T cells. T cells rushed to the battlefield to kill cancer cells with NK cells.
Waa maxay daawaynta unugyada NK?
Magaca buuxa ee unugyada NK waa Unugyada Killer ee Dabiiciga ah (NK), waana kooxda saddexaad ee lymphocytes kuwaas oo ku xidhan unugyada T iyo B ee ciidanka unugyada asaasiga ah. Unugyada NK waxay ku jiraan dhiigga dadka waxayna yihiin "jawaabayaasha ugu horreeya". Waxay la mid tahay sarkaal roondo ah oo ku jiray shaqada jidhka. Sida dhiiggu u socdo, inta lagu jiro roondada, unugyada NK waxay sii wadaan inay la xiriiraan unugyada kale. Marka jidhka laga helo cillado aan caadi ahayn Isla markiiba iska tuur unugyada. Waxay weerareen oo ay sii daayeen qaybo cytotoxic ah oo ay ku jiraan perforin iyo granzyme oo ku yaal xuubka unugyada bartilmaameedka ka hor inta aan unugyada T la geynin, taasoo kicinaysa unugyada kansarka si ay is-burburiyaan. Waxay sidoo kale baabi'iyaan unugyada asliga ah ee wareegaya kansarka waxayna caawiyaan ka hortagga metastasis.
Marka hore, waa habka difaaca jirka ee jidhka bini'aadamka. Dhab ahaantii waa dagaalyahan hore u socda. Ku dhawaad dhammaan unugyada burooyinka waxaa si gaar ah u weerari doona unugyada NK.
Marka labaad, "fooraha" ee habka difaaca jirka ayaa leh jawaab celin waqtigeeda ku saabsan xaaladda. Marka "xaaladda cadawga" la helo, waxay si dhakhso ah u "warbixisaa" waxayna bilawdaa difaaca difaaca iyo difaaca difaaca ee habka difaaca jirka oo dhan.
Saddexaad, waxay leedahay saameyn ballaaran oo antitumor ah, uma baahna aqoonsi gaar ah oo buro ah, kumana xaddidna waxqabadka weyn ee histocompatibility complex (MHC) ee dhaqdhaqaaqa xakameynaya dusha unugyada. Waqtiga bilawga ah waa kan ugu dhaqsaha badan, unugyada T-na waxay u baahan yihiin inay maraan soo bandhigida antigen ka hor inta aysan kala saarin "cadowga iyo cadowga".
Sidaa darteed, saameynta dilka kansarku waa mid awood badan.
Saddexda hab ee waaweyn ee dilaaga kansarka ee unugyada NK
Unugyada NK waxay door muhiim ah ka ciyaaraan safka koowaad ee difaaca ka hortagga kansarka. Unugyada NK waxay leeyihiin saddex saameynood oo ka hortagga kansarka:
Marka hore, dilka tooska ah ee unugyada burooyinka. U dila unugyada burooyinka by post-perforin iyo granzymes ama reseptors dhimashada;
Marka labaad, iyada oo loo marayo dheecaanka cytokines iyo chemokines si ay u ciyaaraan doorka unugyada nidaaminta nidaamka difaaca, firfircoonida unugyada T iyo saameynta kale ee dilka;
Saddexaad, saamaynta ADCC (saamaynta cytotoxic-ku-tiirsanaanta unugyada-ku-tiirsanaanta unugyada) ayaa la sameeyay. Marka unugga B uu helo unugga kansarka, wuxuu si aamusnaan ah uga tagi doonaa antibody-ka gaarka ah ee IgG unugga kansarka si uu calaamad u xasuusiyo unugyada NK. Markay arkaan unugga NK ee ku suntan, waxay arkaan mid dilaya. Iyada oo la kaashanayo macrophages iyo unugyada B, niyadda dilka kansarka aad buu u kordhay.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: Unugyada T Cell iyo NK daawaynta unug ee Hindiya
NK unugyada difaaca jirka
Inkasta oo ay si dhakhso ah u difaaci karaan oo ay si toos ah u weerari karaan unugyada burooyinka, tirada unugyada NK ee jidhka bini'aadamka waa yar yihiin, oo xisaabiya kaliya 10% unugyada dhiiga cad. Waxayna daraasaddu sheegtay in da'da 25 sano ka dib, bani'aadamku ay hoos u dhigeen difaaca oo ay yareeyaan tirada unugyada NK. Tirada iyo waxqabadka unugyada NK ee bukaanka burooyinka iyo bukaanada ka dambeeya burooyinka ayaa isbeddelay ilaa xad, mana ciyaari karaan door wax ku ool ah oo lagula dagaallamayo saameynta kansarka.
Researchers are now developing multiple methods to release NK cell activity against tumors, thereby increasing the efficacy and specificity of NK cell-based therapies. At present, there are three main types of NK cell strategies for tumor immunotherapy adduunka.
01.In vitro firfircoon autologous ama allogeneic NK daaweynta unugyada
Waqtigan xaadirka ah, diiradda gudaha iyo caalamiga ah ee "korsashada" daaweynta unugyada NK waa in laga soo ururiyo unugyada NK deeq-bixiyeyaasha si dhow ula xiriira oo lagu duro bukaanka. Tani waxay caddaysay inay badbaado tahay, oo ka duwan daawaynta unugyada T-unugga, unugyada NK ma keenaan cudur-tallaalid-ka-hortagga-martigelinta unugyada qaataha.
02. Isku darka unugyada NK iyo unugyada difaaca jirka ee monoclonal (sida difaaca isbaarada isbaarada) si loo kiciyo cytotoxicity-gaar ah oo ka hortag ah
Isku darka daawaynta isbaarada iyo daawaynta kale ee NK-dugta waxay beegsan kartaa noocyo badan oo burooyin ah oo aan hadda ka jawaabin daawaynta jirta.
Inkasta oo habka dilka ee unugyada NK ee ka soo horjeeda burooyinka uusan ahayn mid gaar ah oo kuma xirna aqoonsiga antigens-la-xiriirka ah ee buro, waxaa sidoo kale jira hababka kicinta ama xakamaynta isbaarooyinka difaaca. Ligands oo ay muujin karaan unugyada burooyinka ee ka soo horjeeda isbaarooyinka difaaca unugyada NK waxay joojin karaan unugyada NK ee dhexdhexaadinta unugyada burooyinka. Sidaa darteed, si loo xaddido xannibaaddan, isbaarooyin is-hortaag ah oo is-hortaag ah oo ka-hortagga unugyada burooyinka-NK ayaa hadda la soo saarayaa Ka-hortagga unugyada.
Sida cetuximab ka dhanka ah EGFR, cetuximab waxay dhaqaajin kartaa saamaynta ADCC ee unugyada NK waxayna bilaabi kartaa jawaab celinta la qabsiga ee unugyada NK.
In addition, studies have found that PD-1 in NK cells is highly expressed in several cancers, including head and neck cancer, thyroid cancer, Hodgkin’s lymphoma (HL), digestive tract cancer (esophageal cancer, liver cancer, colorectal cancer, gastric cancer and biliary cancer ), Breast cancer, Kaposi’s sarcoma, renal cell carcinoma and multiple myeloma. Recent studies have shown that when PD-L1-negative tumors respond to anti-PD-L1 treatment, this effect may be mediated by PD-L1 + NK cells. PD-L1 + NK cells treated with anti-PD-L1 showed enhanced activation and effector function.
03.Dhismaha difaaca unugyada CAR-NK
Unugyada NK-ka-soo-dhoweeyey ee Chimeric antigen: waxay si weyn u wanaajin kartaa
e gaarka ah ee waxtarka unugyada NK. Fikirkani wuxuu la mid yahay dhismaha CAR-T: CAR waxaa ka mid ah domain aqoonsiga ka baxsan unugyada (sida scFv) si loo aqoonsado antigens-ka gaarka ah ee buro; domain transmembrane, iyo domain signaling intracellular (CD3ζ silsilad) waxay keeni kartaa unugyada NK.
Bukaankee ugu fiican daawaynta unugga NK?
Waqtigan xaadirka ah, daaweynta difaaca unugyada gudaha iyo kuwa caalamiga ah ee NK ayaa si ballaaran loo darsay. Unugyada NK ee gudaha iyo kuwa Jabbaan ayaa inta badan lagu bartilmaameedsadaa burooyinka adag, halka daawaynta NK ee Maraykanka inta badan lagu bartilmaameedsado burooyinka dhiigga.
Immunotherapy-ga unugyadu waxay aragti ahaan u dhigmi karaan marxalad kasta oo kansar ah, sida:
1. Bukaanada rajaynaya inay isticmaalaan unugyada difaaca jirka si ay u hagaajiyaan difaacooda, uga saaraan unugyada kansarka ee haraaga ah, uga hortagaan soo noqoshada, iyo inay dheereeyaan badbaadada ka dib qalitaanka nabarrada.
2. Ka dib daaweynta shucaaca iyo kiimoterabiga, bukaanada leh difaac hooseeya iyo waxyeellooyin muuqda (sida rabitaanka cuntada oo luma, lallabbo, timo lumis, caabuq maqaarka, iwm.) ayaa la filayaa inay kordhiyaan saameynta daaweynta kemoradiotherapy.
3. Bukaannada ka baqaya dhibaatooyinka soo raaca ee daaweynta shucaaca iyo kiimoterabiga waxayna rajeynayaan inay isticmaalaan habab daaweyn oo kala duwan si ay u gaaraan saameynta daaweynta.
4. Bukaannada qaba unugyada kansarka ee horumaray ayaa ku faafay jirka oo dhan, laakiin bukaannada hababka daaweynta caadiga ah way awoodi waayeen inay sidaas sameeyaan, iyagoo rajeynaya inay sii dheereeyaan badbaadada iyo hagaajinta tayada nolosha.
Qodobbada muhiimka ah: Immunotherapy-ga unuggu wax saameyn ah kuma laha burooyinka sii yaraanaya ee bukaannada qaba kansarka sare. Saamaynta bukaanada qaba kansarka sare waa in la ilaaliyo tayada nolosha iyo dheeraynta nolosha. Sida ugu habboon ee loo daweeyo unugyada difaaca jirka waa qalliin ka dib. Sida daawaynta adjuvant ee qaliinka ka dib, si loo xakameeyo soo noqoshada iyo in la ilaaliyo daawaynta hore ee bukaanada qaba kansarka hore ilaa dhexe; Marka lagu daro kiimoterabiga, daawooyinka la beegsaday, PD1 inhibitors iyo daawaynta kale, saameyntu way fiicnaan doontaa.
Cellular immunotherapy is not suitable for all cancer patients. Like sarcoma suffered by Wei Zexi, it is a rare tumor with a high degree of malignancy. There is currently no good treatment in the world. Therefore, cellular immunotherapy is naturally not suitable. . Therefore, please ensure that you, your family members, and your friends are far away from the false information on the Internet. Before you choose to receive treatment, you must be evaluated by experts in a regular and authoritative cancer hospital. In addition, the cost of cellular immunotherapy is relatively high, not every Families can accept it. Everyone must choose carefully according to the family’s economic conditions.
Xataa haddii aanad aqbali karin daawayntan horumarsan, qof walba waa in aanu yeelan shucuur xun. Waxaan dareemayaa in tignoolajiyadan cusub loo diyaariyey dadka hodanka ah, dadka saboolka ahna waa inay sugaan dhimashada markay qaadaan kansarka. Maskaxdani hubaal maaha mid wanaagsan. Dhammaanteen waan ognahay in dabeecadda wanaagsan ay tahay hubka ugu waxtarka badan ee lagu jabiyo kansarka. Bukaanno badan ayaa ka nafisiyay dhammaan noocyada shaqada iyo cadaadiska nolosha ka dib markii ay la kulmeen cudurka kansarka, waxay ka nafiyeen nacaybka ay u qabaan dadka ku xeeran qaarkood, waxay barteen cafiska, waxay barteen mahadnaqa, waxayna gebi ahaanba beddeleen qaab nololeedkoodii. Cunista cunto caafimaad leh, jimicsi joogto ah, shaqo joogto ah iyo nasasho, iyo hagaajinta maskaxdaada waxay sidoo kale gaadhi kartaa cimri dheer, taas oo aad muhiim u ah.
Waa kuwee cosbitaalada bixiya daawaynta unugyada NK ee Hindiya?
NK Cell therapy waa tignoolajiyada unugga oo tan ay bixiyaan shirkadaha daweynta unugga. Waqtigan xaadirka ah waxaa jira hal shirkad oo kaliya oo la ansixiyay oo bixisa daaweynta NK Cell ee Hindiya. Faahfaahinta ku saabsan u-qalmitaanka bukaanka ee daawaynta Unug ee NK fadlan wac at + 91 96 1588 1588 ama u soo dir bukaanka warbixinnada caafimaadka kansarfax@gmail.com.
Dhakhtarka ugu fiican ee daaweynta unugyada NK ee Hindiya
Sida hore loo soo sheegay daaweynta unugyada NK ee Hindiya waxaa bixiya shirkadaha daaweynta unugyada waxayna leeyihiin koox dhakhaatiir ah oo u gaar ah kuwaas oo kormeera caafimaadka bukaanka inta lagu jiro daaweynta.
Waa maxay qiimaha daawaynta unugga NK ee Hindiya?
Qiimaha daawaynta unugyada NK ee Hindiya waxay ku xidhan tahay nooca iyo baaxadda kansarka bukaanka. Si kastaba ha ahaatee tixraaca Qiimaha daawaynta Unug NK ee Hindiya way kala duwanaan kartaa inta u dhaxaysa $9000-12000 USD.
Waa maxay habka loogu talagalay daawaynta unugyada NK ee Hindiya?
Habka iyo tirada faleebooyinka waxay ku xiran tahay qof ilaa qof iyo xadka & nooca kansarka. Fadlan u soo dir warbixinnada caafimaadka iimaylka hoose iyo lambarka WhatsApp-ka waxaanu kula soo laaban doonaa qorshe daawayn shakhsi ahaaneed.
Si aad u ogaato wax ku saabsan daawaynta unugyada NK wac + 91 96 1588 1588 ama u soo dir warbixinnada caafimaadka bukaanka kansarfax@gmail.com.