Febraayo 2024: daawaynta lymphocyte-ka-faro-galka ah (TIL). daawayntu waa hab suurtagal ah oo ka faa'iidaysanaya habka difaaca jidhka si loola dagaallamo burooyinka adag. Aaggan daaweynta ee Shiinaha ayaa si degdeg ah u socda sababtoo ah maalgashiga sii kordhaya ee qaranka ee daaweynta unugyada iyo ganacsiyada tafatirka hidda-wadaha, inkastoo ay yaraayeen. Daaweynta TIL ee Shiinaha waxay la kulantaa dhibaatooyin ay ka mid yihiin kaabayaal aan ku filnayn, maqnaanshaha borotokoollada la aasaasay, iyo faham la'aanta xulashada bukaanka ee ugu fiican iyo isku darka daaweynta. Soo ifbaxa receptor antigen-kimeric (CAR)-Daawaynta unugyada T ee Shiinaha waxay kobcisay jawi wanaagsan oo loogu talagalay horumarinta daaweynta TIL, kor u qaadista iskaashiga ka dhexeeya hay'adaha iyo shirkadaha gaarka ah.
Horumarka iyo Isticmaalka
Dr. Steven Rosenberg wuxuu si guul leh ugu daaweeyay jiirka malignancies TIL-yada iswada leh dabayaaqadii 1980-meeyadii, markii ugu horeysay ee uu horumariyo. Daaweynta TIL. Since then, TIL therapy has advanced substantially, showing great effectiveness in specific solid tumors, especially melanoma, cervical cancer, and colorectal cancer.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: CAR T-Cell Therapy ee Shiinaha
Dhibaatooyinka Daaweynta and Progress
Grit Biotechnology, headquartered in Shanghai, secured $60 million in Series B funding to advance the development of its TIL candidates, with a primary emphasis on melanoma, cervical, and kansarka sanbabada. These efforts are in line with worldwide patterns in TIL therapy, which is more frequently incorporating combination treatments with other immunotherapies, like immune checkpoint blocking drugs.
Recent studies have emphasized that the composition and location of TILs within tumors are crucial factors affecting prognosis and treatment results. Comprehending the intricate relationships between TILs and the buro microenvironment is crucial for enhancing TIL therapy tailored to specific tumor types and refining patient categorization.
Qorshayaasha mustaqbalka
Dhowr arrimood oo waaweyn ayaa u baahan fiiro gaar ah si si buuxda looga faa'iidaysto awoodda Daaweynta TIL ee Shiinaha.
Habaynta: Halbeegista waxay ku lug leedahay abuurista borotokool joogto ah oo loogu talagalay go'doominta TIL, korriinka, iyo gaarsiinta si loogu oggolaado isbarbardhigga fudud ee u dhexeeya daraasadaha bukaan-socodka iyo kor u qaadista fahamka natiijooyinka tijaabada.
Xulashada Bukaanka: Samaynta baayacmushtar xoog leh oo si la isku halleyn karo loogu doorto bukaannada ka faa'iideysanaya daawaynta TIL ayaa muhiim u ah qoondaynta kheyraadka ugu wanaagsan iyo sare u qaadida waxtarka daaweynta.
Wadashaqeyn: Dhiirigelinta iskaashiga machadyada tacliinta, isbitaallada, iyo la-hawlgalayaasha warshaduhu waxay kor u qaadi doonaan hal-abuurnimada waxayna dedejin doontaa tarjumaada daawaynta cusub ee TIL ee ku-dhaqanka bukaan-socodka.
Waxbarashada: Bixinta barnaamijyo tababar oo la habeeyey iyo ilaha waxbarasho ee xirfadlayaasha daryeelka caafimaadka ee ku hawlan Daaweynta TIL waxay kor u qaadi doontaa hababka ugu fiican waxayna kordhin doontaa wacyiga horumarka hadda ee aagga.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: CAR T daawaynta unugga ee myeloma badan ee Shiinaha
Diirada la kordhiyo ee cilmi baarista iyo waxbarashada ee Shiinaha ayaa taageeri doonta horumarinta TIL therapy ee burooyinka adag iyada oo la kobcinayo hal-abuurka iyo abuurista daweyn ammaan ah oo hufan.
Waa maxay xaaladda hadda jirta ee daawaynta lymphocyte ee gudaha Shiinaha ee buro?
Tumor-infiltrating lymphocyte (TIL) therapy is still at an advanced stage in China. According to recent rumors, the US Food and Drug Administration may provide approval to employ TIL treatment to treat some cancers. It has great promise for treating solid cancers. Using soo -dhoweeyaha kiimikada chimeric (CAR)-T cells for treatment has sped up the growth of TIL therapy in China, making it easier for companies that work in cell therapy and gene editing to do well.
Tilmaamaha muhiimka ah ee daaweynta TIL ee Shiinaha waa:
• Kaabayaasha dhaqaalaha oo xaddidan iyo hab-maamuus qeexan
• Focus on melanoma, cervical, and kansarka mindhicirka
• Wadashaqeynta hay'adaha caalamiga ah iyo shirkadaha gaarka loo leeyahay
Barnaamijyada waxbarashada ee xirfadlayaasha caafimaadka
Iyadoo daawaynta TIL ay muujisay guulo aan caadi ahayn oo ku saabsan noocyada burooyinka gaarka ah, hirgelinteedu weli way adag tahay arrimo ay ka mid yihiin wax soo saarka TIL oo hooseeya, adkaysiga TIL ee liita ka dib faleebo, iyo caqabadaha horumarinta borotokool joogto ah.
Fursadaha mustaqbalka ee daaweynta TIL ee Shiinaha waxaa ka mid ah:
• Go'doominta, balaadhinta, iyo farsamooyinka maamulka ee TIL oo la habeeyey
• Xulashada bukaanka oo la hagaajiyay iyo isku darka daawaynta
• Wadashaqeyn wanaagsan oo dhexmarta aqoonyahannada, isbitaallada, iyo la-hawlgalayaasha warshadaha
• Ilaha waxbarasho ee la ballaariyay ee bixiyeyaasha daryeelka caafimaadka
Tallaabooyinkani waxay ujeedadoodu tahay in la kordhiyo isticmaalka daawaynta TIL ee Shiinaha, taasoo ugu dambeyntii horseedaysa badbaado iyo daaweyn adag oo buro ah.
Waa maxay noocyada kansarka ugu badan ee lagu daweeyo daawaynta TIL?
Noocyada ugu badan ee kansarka ee lagu daweeyo daawaynta lymphocyte-ka-faro-gelinta (TIL) waa:
Melanoma: Daawaynta TIL waxay wax ku ool u tahay daawaynta melanoma, oo ah nooc ka mid ah kansarka maqaarka.
Kansarka ilmo-galeenka: TIL therapy has shown promising outcomes in cervical cancer patients, resulting in tumor reduction and increased survival rates.
Kansarka mindhicirka: Daaweynta TIL waxay muujisay guul horudhac ah oo laga gaaray bukaannada kansarka mindhicirka, taasoo soo jeedinaysa suurtagalnimada kansarka noocan ah.
Iyadoo daawaynta TIL ay weli ku jirto wejigeeda hore ee Shiinaha, cilmi-baarista sii socota iyo daraasadaha kiliinikada ayaa baaraya codsigeeda burooyin badan oo adag, oo muujinaya la qabsigeeda iyo ballanqaadka isticmaalka ballaaran ee mustaqbalka.
Qiimaha daawaynta TIL ee Shiinaha
Daaweynta TIL waxay ku jirtaa marxalado tijaabo ah hadda, iyo guud ahaan Qiimaha daawaynta TIL ee Shiinaha waxa laga yaabaa inay u dhaxayso $60,000 iyo $125,000 USD. CAR T Qiimaha daawaynta unug ee Shiinaha inta u dhaxaysa $45,000 iyo $80,000 USD. Qiimaha daawaynta TIL way kala duwanaan kartaa iyadoo ku xidhan qorshaha daawaynta gaarka ah, cusbitaalka, iyo arrimo kale. Waxaa lagu talinayaa inaad la tashato bixiye daryeel caafimaad ama isbitaal ku yaal Shiinaha si aad u hesho macluumaad dheeraad ah oo ku saabsan kharashka daawaynta TIL.
