Cudurrada neerfaha waa dhibaatooyin waaweyn oo adduunka oo dhan ah sababtoo ah waxay keenaan dhimasho iyo naafo badan. Daawaynta dhaqameed had iyo jeer ma shaqayn, taas oo keentay isbeddel ku wajahan hababka cusub sida daawaynta unugyada ku salaysan. Maadaama ay yihiin kuwo awood badan oo isu beddeli kara noocyo kala duwan oo unugyo ah, unugyada asliga ah ee mesenchymal (MSCs) waxay noqdeen doorasho wanaagsan oo loogu talagalay daaweynta unugyada allogenic. Unugyadaan, oo ka yimid mesoderm iyo ectoderm, ayaa laga yaabaa inay awoodaan inay caawiyaan daaweynta cudurrada neerfaha iyagoo u beddelaya unugyo u eg neuron, oo saameeya habka difaaca, iyo dhiirigelinta neerfayaasha.
Waa maxay Unugyada stem Mesenchymal ee laga Sameeyay?
MSCs waa unug aan hematopoietic ahayn oo laga heli karo unugyada embriyaha koraya iyo dadka waaweyn labadaba. Waxay samayn karaan nuqullo naftooda ah waxayna isku beddeli karaan noocyo kala duwan oo unugyo ah, taas oo ka dhigaysa inay faa'iido u leeyihiin daryeelka caafimaadka. Ereyga "mesenchymal" wuxuu ka yimid xaqiiqda ah inay ka yimaadeen unug isku xira uurjiifka, kaas oo ah meesha lafaha, carjawda, iyo murqaha laga sameeyo. Sababtoo ah waxay noqon karaan noocyo badan oo kala duwan oo unugyo ah, MSCs waxay muujinayaan calaamado dusha sare ah waxayna leeyihiin suurtogalnimada daaweynta unugyada alogenic.
Suurtagalnimada in lagu daweeyo xanuunada Neerfaha
Researchers have found that human umbilical cord mesenchymal stem cells (hUC-MSCs) can protect neurons and stop them from dying. They do this by releasing cytokines and neurotrophic factors that help neurons grow again. Because of these qualities, MSCs can be used to treat brain diseases like Alzheimer’s and stroke. Even though researchers are still working to improve MSC-based therapies, it is still hard to fully use their promise to treat complex neurological disorders.
Gabagabadii, daawaynta unugyada asliga ee mesenchymal waa hab cusub oo muujinaya awood badan oo lagu daweyn karo xanuunada dareemayaasha. Iyadoo cilmi baaris dheeraad ah loo baahan yahay si loo xalliyo dhibaatooyinka hadda jira loona wanaajiyo natiijooyinka daaweynta, MSCs waa habab dhinacyo badan leh oo leh awood badan si ay uga dhigaan nolosha dadka qaba xaaladaha neerfaha.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: Dawaynta unugyada asliga ah
Waa maxay faa'iidooyinka daaweynta unugyada asliga ah ee mesenchymal ee xanuunada neerfaha?
Natiijooyinka daraasadda ayaa muujinaya in daawaynta unugga stem mesenchymal ay ka caawin karto dhowr cudur oo neerfaha ah, oo ay ku jiraan:
Ilaalinta Neuro iyo Saamaynta Ka-hortagga Apoptotic: Unugyada stem Mesenchymal (MSCs) waxay caawiyaan ilaalinta neerfayaasha iyagoo siidaaya cytokines iyo arrimaha neurotrophic ee dhiirigeliya neerfayaasha. Tani waxay kaa caawin kartaa daaweynta xaaladaha sida cudurka Alzheimers iyo istaroogga.
Ka soo kabashada Ischemic Stroke oo la hagaajiyay: Cilmi baaris ayaa muujisay in ku-tallaalidda MSC ay ka caawin karto dadka inay si dhaqso ah uga soo kabtaan istaroogga ischaemic. Tani waxay tusinaysaa in daawaynta ku salaysan MSC loo isticmaali karo daawaynta xaaladaha neerfaha.
Daawaynta Hababka Kala Duwan ee Dayactirka Nidaamka Dareenka: In vitro iyo daraasado hordhac ah ayaa muujiyay in MSCs ay faa'iido u leeyihiin hagaajinta habka dareemayaasha ee cudurro badan sababtoo ah waxay leeyihiin sifooyin gaar ah.
Faa'iidooyinka Muhiimka ah ee Qaababka Xoolaha iyo Bukaannada: Daraasaduhu waxay muujiyeen in MSC-yadu ay faa'iidooyin la taaban karo ku leeyihiin noocyada xayawaanka ee cudurrada neerfaha iyo bukaannada qaba dhaawaca neerfaha. Tani waxay muujinaysaa ballanqaadka daaweynta MSC si loo hagaajiyo natiijooyinka xanuunka neerfaha.
Gebogebadii, daawaynta unugyada asliga ah ee mesenchymal waxay muujinaysaa ballanqaad ilaalinta neerfayaasha, dedejinta soo kabashada istaroogga, siinta hab badan oo hab-dhiska habdhiska dareenka ah, iyo muujinta faa'iidooyinka waaweyn ee noocyada xayawaanka iyo dadka qaba xanuunka neerfaha.
Waa maxay dhibaatooyinka ka iman kara daawaynta unugyada asliga ee mesenchymal ee xanuunada neerfaha?
Qaar ka mid ah waxyeelooyinka suurtagalka ah ee isticmaalka unugyada tarma ee mesenchymal si loo daaweeyo cudurrada neerfaha waa:
1. Falcelinta difaaca jirka: Ku-tallaalidda Allogeneic MSC waxay keeni kartaa jawaab celin difaac, taasoo keeni karta dhibaatooyin sida cudurka tallaalka-ka-horjeedka-martida (GvHD) ama jirka oo diida unugyada la soo diray.
2. Tumor formation: Sababtoo ah MSC-yadu wali lama qaybin, waxaa jirta fursad yar laakiin dhab ah oo ah in buro ay samaysmaan.
3. Cudur: Sababtoo ah habka difaaca jirkooda ayaa daciifay inta lagu jiro daawaynta, dadka difaaca jirka ah ee qaata daawaynta MSC waxay u badan tahay inay qaadaan caabuqyo.
4. Samaynta Teratoma: Sababtoo ah MSC-yadu waxay isu beddeli karaan noocyo kala duwan oo unugyo ah, waxaa jirta khatar suurtagal ah oo ah samaynta teratoma, taas oo ah nooc naadir ah oo buro ah.
5. Dhibaatooyinka xididada: Ku-tallaalidda MSC waxay keeni kartaa dhibaatooyin xididdada dhiigga, sida xinjirowga dhiigga ama embolism, taasoo ka gooyn karta aagga inuu helo dhiig.
6. Dareen-celinta bararka: Daawaynta MSC waxay keeni kartaa falcelin barar ah, taas oo ka dhigi karta cabashooyinka neerfaha ama sababi kara dhibaatooyin cusub.
Gebagebadii, daawaynta unugyada asliga ee mesenchymal waxay leedahay awood badan oo lagu daweyn karo cudurrada neerfayaasha, laakiin waxaa muhiim ah in la ogaado khataraha iyo dhibaatooyinka ka iman kara. Si daawaynta ku salaysan MSC ay si fiican u shaqeyso oo ay u yarayso khatarahaas, daraasado badan ayaa loo baahan yahay.
Waa maxay xanuunada ugu badan ee neerfaha lagu daweeyaa daawaynta unugyada asliga ee mesenchymal?
Kuwani waa xaaladaha ugu badan ee neerfaha ee daaweynta unugyada stem mesenchymal loo isticmaalo in lagu daweeyo:
1. Dhaawacyada Maskaxda, Xadhkaha Laf-dhabarta, iyo Dareemaha Duleedka: Daaweynta unugyada asliga ah, oo ay ku jiraan unugyada tarma ee mesenchymal, ayaa loo isticmaalaa in lagu daweeyo dhaawacyada maskaxda, xangulada, iyo neerfayaasha durugsan.
2. Madax-dhiigfuran: Daaweynta unugyada asliga ah ee Mesenchymal waxay muujisay ballanqaad daawaynta istaroogga, iyada oo ujeedadu tahay in dadka laga caawiyo inay si dhakhso ah u bogsadaan oo ay helaan natiijooyin wanaagsan.
3. Cudurka Alzheimers: Marka laga hadlayo cudurka Alzheimers, cilmi-baaristu waxay muujineysaa in unugyada asliga ah ee 'mesenchymal stem' laga yaabo inay gacan ka geystaan daawaynta cudurka iyagoo ilaalinaya neerfayaasha iyo joojinta dhimashada unugyada iyagoo siidaaya cytokines iyo arrimo faa'iido leh.
4. sclerosis badan (MS): Mesenchymal stem cells have been tested in tijaabada caafimaadka as a possible treatment for MS, and some studies have shown that they may be able to help people with this neurological disease.
Marka la soo koobo, daawaynta unugyada asliga ah ee mesenchymal waxaa badanaa loo isticmaalaa in lagu daweeyo xaalado kala duwan oo neerfaha, sida maskaxda, laf-dhabarta, iyo dhaawacyada dareemayaasha durugsan, iyo sidoo kale cudurka Alzheimers, sclerosis badan, iyo istaroog.
Waxaa laga yaabaa inaad jeceshahay inaad akhriso: Unugyada stem Mesenchymal (MSC) iyo Plasma-hodanka ku ah platelet (PRP) ee daaweynta osteoarthritis jilibka
