Sebtembar 2022: Sida laga soo xigtay daraasad lagu daabacay Joornaalka Baadhitaanka Kiliinikada, injineer ka tirsan Jaamacadda Houston (UH) ayaa laga yaabaa inuu helay hab lagu aqoonsado bukaannada lymphoma ay u badan tahay inay ka jawaabaan daawaynta unugyada antigen-ka ee chimeric (CAR).
Physicians can expedite treatment and maybe save more lives if they are aware of which lymphoma patients react to CAR T-cell therapy. On the other hand, sharing light on people who react poorly and experience serious side effects can open up more possibilities for alternative treatments.
Cilmi-baarayaashu waxay baaritaankooda ku heleen xiriir gaar ah oo ka dhexeeya borotiinka unugyada T-ga CD2 iyo soo-dhoweeyaha kansarka CD58.
In the tumours of lymphoma patients who benefit more from CAR T-cell daaweynta, the CD2 ligand CD58 is expressed at higher levels, according to study author Navin Varadarajan, PhD, MD Anderson professor of chemical and biomolecular engineering.
borotiinka CD2 unugga AT waxa ku xidhan CD58. Marka CD58 uu kiciyo CD2, borotiinku wuxuu isu beddelaa unug ka takhalusi kara unugyada kansarka marka ay taabtaan.
According to certain recent studies, cancer can be treated by using the patient’s own biological system. One particular technique, called CAR T-cell daaweynta, modifies T cells in the lab so that they will fight cancer cells once they have returned to the body. The consequences of this life-saving procedure could linger for ten years or longer.
Si loo sameeyo baaritaan qoto dheer oo ku saabsan xiriirka ka dhexeeya CD58 iyo CD2, Varadarajan wuxuu la kaashaday koox cilmi baaris ah oo ka socota Jaamacadda Texas MD Anderson Cancer Center.
Varadarajan wuxuu la kaashaday Sattva Neelapu (MD Anderson) si uu u wasakheeyo burooyinka bukaanka ka hor daaweynta CAR T oo uu baaro muujinta unugyada iyadoo la adeegsanayo TIMING (Timelapse Imaging Microscope In Nanowell Grids) farsamada Varadarajan uu ku sameeyay shaybaarkiisa. Tignoolajiyadan hal-unug ee-sare ee la soo saaray waxay qiimayn kartaa sida unugyadu u dhaqaaqaan, u hawlgeliyaan, dilaan, u badbaadaan, iyo is-dhexgalka.
The scientists discovered that tumours expressing higher amounts of the cancer receptor CD58 responded better to CAR T-cell daaweynta based on the hundreds of interactions they saw between T cells and tumour cells using TIMING.
Varadarajan stated in the news announcement, “We found that CD2 on T cells is related with directional migration. Death and serial killing are accelerated by the interaction between CD2 on T cells and CD58 on qanjiro unugyada.
Varadarajan wuxuu higsanayaa inuu ganacsi ka sameeyo farsamada TIMING. Waxa uu wax ka asaasay UH-ka ganacsiga CellChorus. Bukaan-socodka waxaa laga yaabaa inay si shakhsi ah u soo gudbiyaan CellChorus unugyadooda bartilmaameedka ah; Unugyadan waxa lagu baari doonaa iyadoo la isticmaalayo tijaabada TIMING; adeeggan weli ma heli karo xirfadlayaasha.
War saxaafadeedka, Varadarajan ayaa yidhi, "Aad ayaan u nasiib badannahay inaan haysano Buundada Tiknoolajiyada oo ah meesha aan ku jirno ee Houston, oo ku xigta xarunta ugu sareysa ee caafimaadka ee qaranka, oo leh marin gaar ah oo loo galo xarumaha daawada ay adagtahay in lagu celceliyo inta badan magaalooyinka kale ee dalka.
