Sababtoo ah kansarka beerka wuxuu leeyahay noocyo badan, dhaxal adag, iyo soo noqoshada fudud, aqoonsashada biomarkers-ka oo saadaalin kara horumarka cudurka ayaa ah hadaf muhiim ah oo lagula dagaallamayo kansarka beerka.
Dhawaan, cilmi baarayaashu waxay soo saareen hab lagu aqoonsado qaabka ugu caansan ee kansarka beerka-hepatocellular carcinoma (HCC) oo ku saleysan kala bixidda biomarkers. Waxay aaminsan yihiin in qaabkan sidoo kale loo isticmaali karo noocyada kale ee kansarka. Daraasadani waxay iftiiminaysaa sida noocyada kaladuwan ee RNA ay gacan uga geysato kansarka, waxayna tilmaamaysaa in noocyadani ay noqon karaan kuwa biomarkers u horseeda horumarka kansarka.
Kala-jajabinta waxaa loola jeedaa habka loo adeegsado in macluumaadka RNA ee laga soo guuriyey macluumaadka ku duugan hiddo-wadaha la saxarro ka hor inta aan loo adeegsan sameynta khariidad borotiin gaar ah. Hidda-wadaha ayaa soo saari kara farriimo badan oo RNA ah, farriin walbana waxay soo saartaa nooc kale oo borotiin ah ama "isomer". Cudurro badan ayaa la xiriira khaladaadka ama kala duwanaanshaha hababka kala-goynta RNA. Khaladaadka ama isbeddelada kala-baxa waxay sababi karaan borotiinno leh shaqooyin kala duwan ama aan caadi ahayn.
Recent research has identified splicing irregularities in kansarka beerka cells. Krainer’s team has developed a method that can comprehensively analyze all RNA information produced by a given gene. The team tested their methods of detecting splice variants in HCC by analyzing RNA information from HCC cells collected from hundreds of patients.
They found that the specific splicing isoform of the AFMID gene is associated with the patient’s low survival. These variants result in cells making truncated versions of the AFMID protein. These unusual proteins are associated with mutations in TP53 and ARID1A buro suppressor genes in adult liver cancer cells.
Cilmi-baadhayaashu waxay qiyaaseen in isbeddelladani ay la xiriiraan heerka hoose ee molecule loo yaqaan NAD +, kaas oo ku lug leh hagaajinta DNA-da dhaawacan. Dayactirka kala goynta AFMID waxay u horseedi kartaa kororka wax soo saarka NAD + iyo kordhinta hagaajinta DNA. Haddii aan tan samayn karno, tolidda AFMID waxay noqon kartaa bartilmaameed daawaynta iyo isha dawooyinka cusub ee kansarka beerka. Tijaabooyin horudhac ah ayaa muujinaya in cilmi-baarista kooxdu ay ku socoto wadadii saxda ahayd, waxaana rajeyneynaa in natiijooyin wanaagsan oo xog ah ay ka faa'iideystaan bukaannada kansarka beerka.
