Saynisyahanno ka tirsan Jaamacadda Delaware iyo Jaamacadda Illinois ee Chicago ayaa daahfuray hab cusub oo lagu dili karo unugyada kansarka beerka iyo xakameynta koritaanka burada. Marka hore, aamusi enzyme-ka gacanta ee muhiimka ah, ka dibna ku dar daroogo awood leh. Cilmi-baadhistani waxay soo dedejin kartaa horumarinta daawaynta cusub ee kansarka beerka oo ay hadda adag tahay in la daweeyo. Qalliinku inta badan maaha ikhtiyaarka kansarka beerka, iyo daawooyinka la heli karo waxtarkoodu xaddidan yahay. Sida laga soo xigtay Machadka Qaranka ee Caafimaadka, in ka badan 82% bukaannada kansarka beerka ayaa dhiman doona shan sano gudahood. Cilmi-baadhayaashu waxay beerteen unugyada kansarka beerka waxayna maareeyeen muujinta enzim ee loo yaqaan hexokinase-2. Ka dib, unugyada waxaa lagu daaweeyay metformin, oo ah daawada sokorowga ee yareysa wax soo saarka gulukooska ee beerka. Ka dib, fiiri sida unugyada kansarku uga jawaabaan luminta hexokinase-2, enzyme ka caawiya unugyada dheef-shiid kiimikaadka cuntada laga helo. Mass spectrometry ayaa loo isticmaalay in lagu falanqeeyo unugyada kansarka ka dibna lagu go'aamiyo qulqulka dheef-shiid kiimikaadka unugyada hexokinase-2 iyo kuwa aan lahayn. Waxay ka shakiyeen in unugyada lumiya hexokinase-2 ay gaajo u dhintaan, laakiin waxaa la yaab leh, bartilmaameedka hexokinase-2 ayaa kaliya saameyn yar ku leh joojinta koritaanka unugyada kansarka. Hub kale, metformin, ayaa kaa caawin kara joojinta unugyada kansarka inay koraan. Waxaan tuseynaa in bartilmaameedka hexokinase-2 ay dhab ahaantii noqon karto istaraatiijiyad guul leh oo loogu talagalay daaweynta kansarka, iyo in ay u baahan tahay isticmaalka metformin sida habka magdhowga jiilka labaad. Ugu dambeyntii, koox ka socota Jaamacadda Illinois ee Chicago ayaa tijaabisay saameynta ka saarista isku darka hexokinase-2 iyo daawada kansarka beerka sorafenib ee burooyinka kansarka beerka ee jiirarka. Isku-dhafkan ayaa ka fiicnaa daawaynta oo keliya.
Fahamka Cytokine Release Syndrome: Sababaha, Calaamadaha, iyo Daaweynta
Cytokine Release Syndrome (CRS) waa falcelin habdhiska difaaca oo inta badan ka dhasha daawaynta qaarkood sida immunotherapy ama daawaynta unugga CAR-T. Waxay ku lug leedahay sii-deynta xad-dhaafka ah ee cytokines, taasoo keenta calaamado u dhexeeya qandho iyo daal ilaa dhibaatooyin nafta halis gelin kara sida dhaawaca xubnaha. Maareyntu waxay u baahan tahay kormeer taxadar leh iyo xeelado faragelineed.