Wani sabon bincike da aka gudanar daga jami’ar McMaster da ke kasar Kanada ya bayyana cewa ya gano wani sabon tsarin dabarun magance cutar sankarar myeloid. Ta hanyar kara kuzarin samar da kwayayen mai a cikin kasusuwan kasusuwa da kuma daidaita kananan kwayoyin halittar, zai iya hana kwayoyin cutar sankarar bargo ya haifar da samar da kwayar halitta ta al'ada. Wannan bambancin shine Tsarin dabarun maganin kai tsaye na daidaitaccen maganin yau da alama yana da fa'idodi, ba kawai a waje ba har ma da cikin. (Nat Cell Biol. 2017; 19: 1336-1347. Doi: 10.1038 / ncb3625.)
Myeloid cutar sankarar bargo (AML) tana tattare da tsarawar ƙwayoyin cutar sankarar bargo iri-iri. Marasa lafiya suna fama da kamuwa da cuta mai tsanani da karancin jini saboda ƙarancin samar da ƙwayoyin jan jini na yau da kullun. Tsarin al'ada na yau da kullun yana mai da hankali ne ga kashe ƙwayoyin cutar sankarar bargo tare da ƙarfin wuta, yin watsi da samar da lafiyayyun ƙwayoyin jini.
Dangane da lura da masu cutar sankarar bargo, masu binciken sun tattara adadi mai yawa na samfuran kasusuwa daga masu cutar sankarar bargo don bincike, idan aka kwatanta da zana lafiyayyun kwayoyin halitta a cikin kashin da kashi da cutar sankarar jini, kuma sun gano wannan tasirin kwayoyin mai. Ta hanyar al'adun kwayar halittar in vitro da daskararren samfurin ƙwayar cuta, masu binciken sun gano cewa ƙananan ƙwayoyin cutar sankarar bargo na musamman sun lalata ƙananan ƙwayoyin ƙwayoyin ƙwayoyin cuta a cikin ɓarke, wanda ya haifar da daidaitaccen tsari na ƙwayoyin jini da ƙwayoyin jini da kuma hana samar da jinin al'ada. sel a cikin kashin nama.
Binciken ya bayyana a karo na farko wannan dangantaka tsakanin ƙarnin adipocytes a cikin ƙashi da ƙashi na ƙashi na ƙashi na erythrocytes. Wannan tasirin ba wai kawai saboda yanayin kwayar halittar jini na bargon kashin ba ne, wato, alkuki ya cika, amma kuma rawar adipocytes a cikin tsarin bambance-bambance. Tasirin iyakancewar ƙwayoyin cutar sankarar jini. Wannan binciken yana samar da sabbin dabarun magani game da cutar sankarar myeloid kuma ana sa ran inganta alamun rashin cin nasara a cikin marasa lafiya da cutar sankarar bargo.
Tallafin magani wanda ke inganta samar da ƙwayoyin mai, ƙwayoyin ƙwayoyin ƙashi a cikin ɓarke sun sami nasarar murƙushe ƙwayoyin cutar sankarar bargo, suna ba da sararin samar da ƙoshin lafiya na jini da kuma buɗe ƙofa. Gwajin in vitro, masu hanawa na PPARγ na iya haifar da ƙarni na adipocytes. Ta hanyar canza yanayin kwayar halitta, yana bayar da mahimmanci don samar da kwayar jinin mai kyau kuma a lokaci guda yana hana samuwar kwayoyin cutar sankarar jini, wanda zai iya samar da sabuwar hanyar kai tsaye kai tsaye don mukeloid mukelodia mai tsanani. Wannan dabarun magance kai-tsaye ya zama mafi alkawura fiye da daidaitattun jiyya, waɗanda ba su sami ci gaba sosai ba a cikin fewan shekarun da suka gabata.
Masu binciken sun nuna cewa babban abin da ake amfani da shi a halin yanzu shi ne kashe kwayoyin cuta, canza hanyar tunani, da daukar dabaru daban-daban don sauya yanayin rayuwar kwayar cutar kansa don samun sakamako na magani. Yayin da yake murkushe ƙwayoyin kansa, yana ƙarfafa ƙwayoyin rai don su iya sabuntawa a cikin sabon yanayin da kwayoyi suka haifar.
