An ƙayyade takamaiman sigina na ƙwayoyin cuta waɗanda ƙwayoyin cutar kansar pancreatic ke fitarwa. Yawancin ciwon daji na pancreatic ana gano shi bayan cutar ta yadu, kuma maganin chemotherapy sau da yawa ba shi da wani tasiri a kan rage ci gaban ciwon daji. Ko da tare da magani, yawancin marasa lafiya na iya rayuwa kawai na tsawon watanni shida bayan an gano su da ciwon daji na pancreatic.
A cikin cutar sankara, fibroblasts suna da yawa, suna lissafin kusan kashi 90% na yawan ƙwayar cuta. Wannan matrix din yana hana magungunan anticancer shiga wurin da aka nufa. Bugu da ƙari, ƙwayoyin stromal suna ɓoye abubuwan da ke taimakawa ci gaban ƙari. Masu bincike a dakin gwaje-gwaje na Farfesa David Tuveson a dakin bincike na Cold Spring Harbor (CSHL) sun yi imanin cewa nau'ikan jiyya daban-daban na iya zama mafi kyau. Wani ɓangare na matsalar shine cewa ƙwayoyin sankara a cikin pancreas ana kiyaye su ta matrix mai girma da ke kewaye dasu. Stroma cakuda ne daga abubuwan da ke cikin kwayar halitta da kuma kwayoyin cutar kansar wadanda ake kira da stroma. Duk marurai masu kumburi suna dauke da jini. Cin nasara da tasirin kariya daga matrix din yana da kalubale, amma kamar yadda aka ruwaito a cikin mujallar Binciken Cancer a ranar 26 ga Oktoba, 2018, sabon bayanin da ya fito daga kungiyar Tuveson ya nuna wata dabara ce mai kyau. Sabon binciken ya nuna cewa magungunan da ke yin daidai da hanyar salula ba wai kawai suna hana ƙwayoyin masu tallafawa kumburi a cikin matrix ba, ana iya ɗaukar su cikin yaƙi da cutar kansa.
Mabuɗin matrix shine fibroblasts, wanda zai iya samar da kayan haɗin haɗin matrix ɗin, kuma zai iya samar da abubuwan da ke haɓaka haɓakar ƙwayoyin kansa da kuma hana garkuwar jiki kariya daga sel kansar. A shekarar da ta gabata, ƙungiyar Tuveson ta gano cewa cutar sankara ta hanji ta ƙunshi aƙalla nau'ikan fibroblasts biyu. Typeaya daga cikin nau'ikan yana nuna fasali waɗanda aka san su don tallafawa ciwowar ƙari, ɗayan kuma yana nuna akasi. Labari mai dadi shine cewa asalin fibroblasts ba a gyara shi ba, kuma fibroblasts masu inganta ƙari zasu iya zama abubuwan ƙayyade ƙari. Giulia Biffi, wata mai binciken digiri na biyu a dakin gwaje-gwajen Tuveson, ta bayyana cewa, “Wadannan kwayayen za su iya canzawa zuwa juna, ya danganta da bayanan da suke samu daga kwayoyin halittu da kwayoyin cutar kansa. A ka'idar, zaku iya canza kwayoyin halitta masu inganta kumburi zuwa masu hana kumburi, bawai kawai yana rage kwayoyi masu inganta kumburi ba. ”Sun gano cewa IL-1 na tuka fibroblasts tare da kayan inganta kumburi. Sun kuma gano yadda wata kwayar halitta, TGF-β, ta rufe wannan siginar kuma tana kiyaye fibroblasts a cikin yanayin yiwuwar cutar kansa. Biffi ya ce marasa lafiya na iya cin gajiyar mafi yawan daga haɗin magungunan da ke sa ido kan ƙwayoyin kansa da ɓangaren microenvironmental da ke tallafawa ci gaban su.
https://www.medindia.net/news/pancreatic-cancer-fresh-insights-183360-1.htm
