Binciken da masu bincike suka gabatar a jami'ar Fudan ya nuna cewa sabon hadewar masu sarrafa kwayoyin sunadarai hudu na iya yin binciken daidai ciwon cizon sauro. (Br J Cancer. Sigar kan layi Nuwamba 9, 2017).
The researchers said that we believe that the development of a fast and stable method for screening target proteins in large samples may accelerate the pace of finding new protein biomarkers and drug targets, and may even be individualized in the future. Of proteomes are used in precision medicine.
Mai ciwon daji na pancreatic sun kasance a matakin ci gaba na cutar a lokacin ganewar asali, kuma matsakaicin rayuwa bayan ganewar asali bai wuce 6%. ganewar asali da magani na farko na iya inganta hangen nesa.
The researchers used a variety of mass spectrometry techniques to analyze 150 serum samples from healthy controls, patients with benign pancreatic diseases, and patients with pancreatic cancer, and identified 142 differentially expressed proteins. Finally, the four proteins were included in their biomarker expression profiles: APOE , ITIH3, APOA1 and APOL1.
Through the analysis of the area under the curve (AUC) method, the accuracy of a single protein marker used to distinguish pancreatic cancer patients from healthy controls was between 66.9% and 89.6%. The combination of the four markers can increase the accuracy to 93.7%. The sensitivity of the four-protein biomarker combination in the diagnosis of pancreatic cancer was 85%, and the specificity was 94.1%. If CA19-9 is included in this detection method, the AUC will be increased to 0.99, at which time the sensitivity is 95% and the specificity is 94.1%.
Har ila yau, masu binciken sun yi amfani da maganin rigakafi don tabbatar da bayyanar alamomin sunadaran da ke sama a cikin samfuran ƙari, suna kara tabbatar da amincin wannan sabon hadewar halittar.
Masu binciken sun ce har yanzu aikace-aikacen asibiti na wadannan masu sarrafa kwayoyin halittar har yanzu yana da sauran aiki a gaba. FDA ta Amurka ta ba da izinin haɗaɗɗen alamomin gwajin ƙari daga Tunawa da Sloan Kettering Cancer Center da ake kira IMPACT. IMPACT zai iya saurin gano maye gurbi a cikin kwayoyin halitta 468 da sauran canje-canje kwayoyin a cikin hadadden kwayar halittar jikin mutum.
