FDA ya ba da nasarar maganin sa quzartinib a nasara nasara. Quizartinib ne mai FLT3 inhibitor karkashin bincike don kula da manya marasa lafiya tare da koma baya / refractory Saukewa: FLT3-ITD myeloid cutar sankarar bargo ( AML ). Wannan ganewa zai hanzarta ci gaban tambaya kuma ana sa ran kawo sabbin magunguna ga marasa lafiya da wuri-wuri.
AML m blood and bone marrow cancer that causes dysfunctional cancerous leukocytes to proliferate and accumulate uncontrollably, and affects the production of normal blood cells. The United States this year is expected to have more than 19000 sunan sababbin marasa lafiya da aka gano, kuma fiye da 10000 Ge AML mutuwar. A 2005-2011 Sakamakon binciken ya nuna cewa 5- shekara ta rayuwa kudi na AML marasa lafiya ne kawai 26% , wanda shine mafi ƙasƙanci a cikin kowane nau'in cutar sankarar bargo. FLT3 maye gurbin kwayoyin halitta shine mafi yawan maye gurbi a cikin AML marasa lafiya, yayin da Saukewa: FLT3-ITD shine mafi saurin maye gurbi na FLT3 kwayar halitta, kuma kusan kashi ɗaya cikin huɗu na AML marasa lafiya suna dauke da wannan maye gurbi. Idan aka kwatanta da marasa lafiya waɗanda ba su ɗaukar wannan maye gurbi, marasa lafiya da Saukewa: FLT3-ITD maye gurbi yana da mummunan hasashen, haɗarin sake dawowa da cutar kansa, da haɗarin mutuwa bayan sake dawowa. Ko da waɗannan marasa lafiya sun sami dashen kwayar cutar hematopoietic ( HSCT ), damar sake kamuwa da cutar kansa bayan jiyya har yanzu ya fi na marasa lafiyar da basa dauke wannan maye gurbi. A halin yanzu, babu wani magani da aka yarda da shi don wannan cutar. Sabili da haka, wannan nasarar nasara ana sa ran kawo sabon bege ga marasa lafiya Saukewa: FLT3-ITD .
Baya ga ganewar nasarar farfadowa, tambaya kuma samu FDA cancantar gaggawa don sake dawowa / refractory AML magani , da kuma cancantar magungunan marayu AML bayar da FDA da Hukumar Kula da Magunguna ta Turai ( Ema ). Quizartinib shine har yanzu a cikin matakan bincike da ci gaba kuma ba a yarda da shi a kowace ƙasa ba. Ba a tabbatar da tsaro da haƙuri har yanzu ba. Koyaya, ana sa ran wannan yardar don hanzarta haɓaka maganin, wanda shine kyakkyawan labari ga marasa lafiya.
