Nazari na tsari da ni na Sakuraba da sauran rahotanni daga Jami'ar ChicagoSakamakon bincike ya nuna cewa marasa lafiya da ke fama da ciwon hanta na yau da kullun suna da haɗarin kamuwa da cutar kansar launin fata (CRC), koda kuwa waɗannan marasa lafiya sun karɓi dashen hanta, wannan haɗarin har yanzu yana wanzu. (Gastrointestinal Endosc. Sigar kan layi akan Disamba 21, 2016)
Sakuraba ta ce ba tare da la’akari da abin da ke haifar da ciwon hanta ba, marasa lafiya da ke fama da ciwon hanta na yau da kullun suna da haɗarin CRC, kuma har yanzu akwai wannan haɗarin bayan dashen hanta. Sabili da haka, yakamata a duba marasa lafiya da ke fama da cutar hanta ta yau da kullun ko a sa ido sosai tare da rage ƙarfin CRC.
Sakuraba et al. An kimanta haɗarin CRC a cikin marasa lafiya da ciwon hanta na yau da kullun kafin da bayan jujjuyawar hanta. Masu binciken sun nemo karatu kan haɗarin cutar hanta da CRC na yau da kullun ta hanyar bayanan lantarki kuma sun bincika jimlar marasa lafiya 55 991 a cikin karatun 50. According to Sakuraba, in studies that included patients with hepatitis and cirrhosis, the total standardized incidence rate (SIR) was 2.06 (95% CI 1.46 ~ 2.90, P <0.0001), and the heterogeneity was moderate (I2 = 49.2%) This is most likely due to differences in disease subgroups and research intensity.
Nazarin uku sun nuna cewa marasa lafiya da sclerosing cholangitis na farko (PSC) suna da haɗarin haɗarin CRC (SIR = 6.70, 95% CI 3.48-12.91; P <0.0001), da bambancin matsakaici (I2 = 36.3%), Babu shakka wannan ya dace ga bambanci a tsananin bincike. A cikin waɗannan karatun da suka haɗa da marasa lafiyar da aka yi wa dashen hanta, SIR shine 2.16 (95% CI 1.59 zuwa 2.94, P <0.0001), kuma bambancin ya kasance matsakaici (I2 = 56.4%).
A cikin niA cikin binciken ta, adadin cututtukan hanta da ke da alaƙa da autoimmune yana da alaƙa da haɗarin CRC. Sakuraba ya ce, “A da, an yi tunanin cewa majinyata na PSC ne kawai za su kara hadarin CRC, amma bincikenmu ya nuna cewa hadarin CRC a tsakanin majinyata da sauran cututtukan hanta na yau da kullun zai karu. Irin wannan karuwa yana da matukar muhimmanci. "
Patrick Boland from the Roswell Park Cancer Institute in New York is not a member of the study. He pointed out that most of the patients in the study have cirrhosis, PSC or have received liver transplantation. The risk of CRC in PSC patients is particularly obvious. PSC is associated with inflammatory bowel disease, which is a known risk factor for ciwon daji, which is also the strongest evidence. However, those who have undergone liver transplantation, especially those with underlying autoimmune diseases, have an increased risk of CRC. Organ transplantation requires the use of immunosuppressive agents, which puts the patient at risk of secondary malignancy for a long time. They have evidence that kidney transplant patients have an increased risk of colon cancer. The data from this study showed that the risk of colon cancer in patients who underwent liver transplantation would be doubled.
Boland ya ce waɗannan binciken ba sababbi bane, saboda kumburi da rigakafin rigakafi sune abubuwan haɗarin cutar kansar hanji. Ya yi imanin cewa colonoscopy na iya zama wani ɓangare na gwajin tiyata na metastases na hanta, musamman ga marasa lafiya da PSC. Ya kuma ambaci cewa saboda ciwace -ciwacen da ke faruwa a sassa daban -daban na babban hanji suna da manyan bambance -bambancen halittu, zai zama abin sha'awa a ci gaba da nazarin ko haɗarin cutar yana da alaƙa da babban hanji na hagu ko dama.
