Satumba 2022: Bisa ga binciken da aka buga a cikin Journal of Clinical Investigation, wani injiniya a Jami'ar Houston (UH) na iya gano wata hanyar da za ta gano abin da marasa lafiya na lymphoma zasu iya amsawa ga maganin T-cell na chimeric antigen receptor (CAR).
Likitoci na iya hanzarta jiyya kuma suna iya ceton ƙarin rayuka idan sun san abin da marasa lafiyar lymphoma ke amsawa ga CAR T-cell far. A gefe guda, raba haske kan mutanen da suka yi rashin ƙarfi kuma suna fuskantar mummunan sakamako na iya buɗe ƙarin damar don madadin jiyya.
Masu bincike sun sami alaƙa ta musamman tsakanin furotin T cell CD2 da CD58 mai karɓar ciwon daji a cikin binciken su.
In the tumours of lymphoma patients who benefit more from CAR T-cell far, the CD2 ligand CD58 is expressed at higher levels, according to study author Navin Varadarajan, PhD, MD Anderson professor of chemical and biomolecular engineering.
Sunan furotin CD2 na AT cell yana daure da CD58. Lokacin da CD58 ya kunna CD2, sunadaran suna canzawa zuwa kwayoyin halitta wanda zai iya kawar da kwayoyin cutar kansa akan lamba.
According to certain recent studies, cancer can be treated by using the patient’s own biological system. One particular technique, called CAR T-cell far, modifies T cells in the lab so that they will fight cancer cells once they have returned to the body. The consequences of this life-saving procedure could linger for ten years or longer.
Domin gudanar da bincike mai zurfi game da haɗin kai tsakanin CD58 da CD2, Varadarajan ya haɗu tare da ƙungiyar bincike daga Jami'ar Texas MD Anderson Cancer Center.
Varadarajan ya haɗu tare da Sattva Neelapu (MD Anderson) don lalata ciwace-ciwacen marasa lafiya kafin maganin CAR T da kuma nazarin maganganun tantanin halitta ta amfani da fasahar TIMING (Timelapse Imaging Microscope A Nanowell Grids) wanda Varadarajan ya haɓaka a cikin dakin bincikensa. Wannan babbar hanyar fasaha ta kwayar halitta na iya tantance yadda sel ke motsawa, kunnawa, kashe, tsira, da mu'amala.
The scientists discovered that tumours expressing higher amounts of the cancer receptor CD58 responded better to CAR T-cell far based on the hundreds of interactions they saw between T cells and tumour cells using TIMING.
Varadarajan stated in the news announcement, “We found that CD2 on T cells is related with directional migration. Death and serial killing are accelerated by the interaction between CD2 on T cells and CD58 on linzoma Kwayoyin.
Varadarajan yana nufin tallata fasahar TIMING. Shi ne ya kafa kamfanin CellChorus na tushen UH. Marasa lafiya na iya ƙaddamar da CellChorus sel da aka yi niyya akan mutum ɗaya; wadannan sel za a bincika ta amfani da gwajin TIMING; har yanzu wannan sabis ɗin bai isa ga ƙwararru ba.
A cikin sanarwar manema labarai, Varadarajan ya ce, "Muna da matukar sa'a don samun gadar Fasaha a matsayin wurin samar da incubator a Houston, kusa da babbar cibiyar kula da lafiya ta kasar, tare da samun dama ta musamman ga cibiyoyin magunguna da wahalar yin kwafi a yawancin sauran biranen. kasa.
