Satumba 2022: The treatment of various tumours has been transformed by cell-based immunotherapy, often known as CAR-T cell far. Domin a yi niyya da magance takamaiman nau'ikan cutar sankarar bargo da lymphoma, maganin yana amfani da sel T da aka kirkira ta kwayoyin halitta. Duk da yake tana da yuwuwar warkar da ciwon daji a cikin wasu mutane waɗanda ba za su mutu ba daga cutar, kuma tana ɗauke da haɗarin illoli masu yawa, waɗanda wasu na iya zama masu mutuwa da kuma rushe aikin ƙwaƙwalwa.
A cewar wani bincike na baya-bayan nan daga Makarantar Magunguna ta Jami'ar Washington a St. Louis, gwajin jini mai sauri zai iya taimaka wa likitoci su tantance waɗanne marasa lafiya za su iya samun sakamako masu illa na neurotoxic a cikin kwanaki da makonni masu zuwa. CAR-T cell far. Masu bincike sun gano cewa matakan furotin da ake kira neurofilament light chain (NfL) sun fi girma a cikin mutanen da suka ci gaba da samun matsalolin neurotoxic bayan nazarin samfuran jinin da aka ɗauka daga marasa lafiya kafin, lokacin, da kuma bayan maganin CAR-T. Kafin a fara farfaɗo har ma, akwai adadi mai yawa na furotin da ke nan, kuma waɗannan matakan suna da girma a duk lokacin jiyya kuma har zuwa wata ɗaya bayan haka.
Binciken, wanda aka fitar a ranar 1 ga Satumba a cikin mujallar JAMA Oncology, na iya taimakawa kwararrun likitocin su hango wadannan illolin da za su iya haifar da kisa da kuma ba su damar fara gudanar da magungunan da za su iya rage sakamakon neurotoxic da wuri a cikin jinyar majiyyaci. Bugu da ƙari, yana ba da dandali don farkon rigakafin ƙwayar cutar ƙwayar cuta ta CAR-T ko bincike na rage haɗari.
Jagoran marubuci Omar H. Butt, MD, PhD, malamin likitanci wanda ke ganin marasa lafiya a Cibiyar Ciwon daji ta Siteman a Asibitin Barnes-Jewish da Makarantar Magunguna ta Jami'ar Washington, ya ce, "Bincikenmu ya nuna cewa wasu marasa lafiya da ke karbar maganin CAR-T suna da ciwon daji. lalacewar da ba a iya ganowa a baya ga neurons da ke nan a asali, kafin mu fara shirya su don wannan magani. ” "Ba mu san asalin wannan rauni ba, amma yana da alama yana sa mutane su sami matsalolin neurotoxic. Za mu iya hana ko rage girman waɗannan sakamakon idan mun san wanda ke cikin haɗari a gare su.
An yi amfani da furotin na NfL, babban mai nuna alamar lalacewar jijiyoyi, don auna ko bin diddigin yanayin yanayin jijiya, gami da cutar Alzheimer da sclerosis mai yawa.
A cewar babban marubuci kuma Daniel J. Brennan Farfesa na Neurology Beau M. Ances, MD, PhD, "ana amfani da matakan NfL a cikin jini a matsayin kayan aiki don kimanta tasirin hanyoyin kwantar da hankali na novel na sclerosis mai yawa." "Muna da niyyar yin ƙarin bincike don sanin abin da ke haifar da lalacewar neuronal a cikin masu ciwon daji. Saboda Jami'ar Washington tana da ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwayoyin cuta na CAR-T da ilimi na sama a cikin cututtukan neurodegenerative, wannan haɗin gwiwar da ba a saba gani ba ya yiwu. Yana ba da dama mai ban mamaki don cike giɓi tare da haɗa nau'o'in sana'o'i daban-daban a ƙoƙarin neman mafita mai ban takaici da amfanar mutane.
30 individuals underwent treatment at Cleveland’s Siteman Cancer Center and Case Comprehensive Cancer Center, both of which are affiliated with Case Western Reserve University.
Marasa lafiya waɗanda ba su fuskanci duk wani sakamako masu illa na neurotoxic ba za a iya bambanta su daga waɗanda suka yi haka bisa tushen matakan NfL. Don ganin ko girman girman samfurin zai ba su damar gano marasa lafiya da ke cikin haɗari masu sauƙi, matsakaici, ko matsaloli masu tsanani, masu bincike sun yi niyyar ci gaba da nazarin bayanai daga ƙarin marasa lafiya.
Rikicin na iya bambanta sosai daga ciwon kai, kamewa, shanyewar jiki, da kumburin kwakwalwa zuwa matsalolin maida hankali, batutuwan ƙwaƙwalwa, rashin tunani, wahalar karatu, da ciwon kai. Magungunan steroid masu girma da kuma wasu lokuta na rigakafi-modulating hanyoyin kwantar da hankali waɗanda ke nufin rage kumburi sune manyan hanyoyin da likitoci ke bi da waɗannan matsalolin. Tun da waɗannan hanyoyin kwantar da hankali na iya, abin baƙin ciki, suna lalata tasirin rigakafin ciwon daji na ƙwayoyin CAR-T, likitoci za su gwammace su guji amfani da su a duk lokacin da zai yiwu, don haka yana da matukar taimako don sanin wanda ke cikin haɗarin mafi cutarwa illa.
Wani abin wuyar warwarewa shine cewa ko da yake wasu marasa lafiya suna da sakamako masu illa na neurotoxic kuma daga baya murmurewa daga gare su, matakan NfL da aka haɓaka sun riga sun kasance kuma galibi koyaushe. Wannan yana nuna cewa yayin da matakan NfL ba lallai ba ne su wakilci abin da ke faruwa don haifar da matsalolin marasa lafiya, suna nuna cewa wani abu ba daidai ba ne.
Dangane da ainihin tsarin rashin lafiya, "muna ganin saman dutsen kankara, kuma a nan ne yawancin bincikenmu na gaba ke tafiya," in ji Butt. "Muna ƙoƙarin fahimtar a fili abin da ya haifar da waɗannan gyare-gyare. Kuma daga baya, ko da lokacin da alamun sun ragu, waɗannan matakan NfL masu girma har yanzu suna nan.
We have a study ongoing at Siteman to see if, in fact, these patients continue to have subtle symptoms in terms of cognitive changes or deficits that persist long term,” added co-senior author Armin Ghobadi, MD, an associate professor of medicine and clinical director of the Center for Gene and Cellular immunotherapy at Washington University School of Medicine and Siteman Cancer Center.
