Maganin cutar kansar nono ya samu ci gaba cikin sauri a cikin ƴan shekarun da suka gabata kuma an sami sabbin ci gaba a maganin cutar kansar nono. Daraktan bincike Dr Juha Klefstorm a Jami'ar Helsinki wanda ke aiki na dogon lokaci a cikin aikin bincike da ke da alaƙa da ciwon daji ya gano cewa ana iya kaiwa hari ga ƙwayoyin cutar kansa tare da "cocktail na miyagun ƙwayoyi" wanda ya haɗa da metformin da venetoclax na ciwon sukari, mai hana furotin BCL-2 wanda zai iya haifar da apoptosis a cikin ƙwayoyin kansa. . Tawagar ta gane metformin a cikin sikanin magunguna wanda zai iya taimakawa aikin apoptosis na aiki na venetoclax. An yarda da Venetoclax don kula da wasu cututtukan sankarar bargo amma har yanzu ba don maganin sankarar mama ba.
“This medication combo abuses explicit metabolic vulnerabilities that large amounts of MYC makes in tumo cells. Metformin and venetoclax, when given together, slaughtered breast tumor cells in culture and blocked tumor development in bosom malignant growth creature models. Moreover, the medications effectively executed bona fide breast malignant growth tissue given by breast disease patients. The breast malignancy tests were acquired straight from medical procedures performed in Helsinki University Hospital,” Dr. Klefstrom says.
A kowane hali, ƙwararrun ƙwararrun tun da daɗewa sun gano cewa metformin ban da maganin venetoclax kawai yana kiyaye ciwace-ciwace a cikin iyakokin da ya dace muddin ana kula da berayen da ke da ciwace-ciwacen ƙirji da kyau tare da magungunan; lokacin da aka daina jinyar, ciwace-ciwacen sun koma baya. Binciken ya nuna cewa an fara lodin ciwace-ciwacen daji tare da ƙwayoyin lymphocytes masu kisa; Duk da haka, bayan jiyya sun bace sosai kuma sauran sel masu aiwatarwa sun sanar da PD-1, alama ce ta raguwar tantanin halitta.
Don ba da damar ƙwayoyin da ba su da ƙarfi don yin yaƙi da ƙari, ƙwararrun sun gina wani tsarin jiyya. Don fara da, sun bugi ciwan nono tare da magungunan apoptosis masu aiki da metformin da venetoclax don rage ƙwayar ƙwayar cuta da kuma tayar da ƙwayoyin lymphocytes masu aiwatarwa. Bayan da aka fitar da mahimman ciwace-ciwacen a hankali, an bi da berayen tare da cakuda sau uku: metformin, venetoclax da PD-1-mai mai da hankali kan wakili mai aiki, wanda ake amfani da shi a cikin maganin rigakafi don kiyaye sel masu aiwatarwa da tsayin tsayi.
Maganin kansar nono - Dr Heidi Haikala
Babbar mahaliccin jarabawar Dr Heidi Haikala ta lura da cewa: “Abin birgewa ne yadda muka mallaki damar kawo wahayi daga wurin zaman dakin gwaje-gwaje da dukkan nisan zuwa mashigar cibiyoyin bunkasar cibiyoyin cikin lokacin PhD daya kamfani Mun kasance a shirye don bincikenmu da kuma tsammanin cewa za su iya amfani da ƙananan ƙwayoyin cuta marasa ƙarfi. "
"Wannan lamari ne mai ban mamaki game da yadda masu bincike a cikin duniyar ilimi, ta amfani da nau'ikan nau'ikan ƙwayoyin cuta da amfani da ƙididdigar ilimin su, na iya ƙara bayyanar da sababbin magunguna ga mutane da mummunan ci gaba. Hakanan nuni ne ga irin gagarumin binciken da ake yi a kananan kasashe kamar Finland, "in ji Joel Leverson, Ph.D., Babban Daraktan Kimiyyar a AbbVie kuma daya daga cikin manyan masu kirkirar binciken.
Hope in coming years there will be more developments in the treatment of ciwon nono.
