Maganin ciwon daji na kwakwalwa ya ƙunshi babban matakin ƙwarewa da sabuwar hanya tare da sabuwar fasaha & ana buƙatar magunguna don yaƙar wannan cuta mai saurin kisa. Wani sabon bincike da tsarin kula da cutar kansa ya nuna niyya agogon nazarin halittu na jiki. Haɗaɗɗen abubuwa guda biyu waɗanda ke kai hari kan abubuwan agogon circadian suna lalata nau'ikan ƙwayoyin cutar kansa da yawa a cikin dakin gwaje-gwaje kuma suna rage haɓakar ƙwayar ƙwayar ƙwayar cuta a cikin beraye ba tare da yin tasiri akan sel na yau da kullun ba.
Aikin Circadian
Agogon circadian wani hadadden kayan aiki ne wanda yake sarrafa kidan jikin mutum a kowace rana, misali, hutawa, yanayin zafin jiki, da kuma hade jiki. Ace "agogo" wani yanki ne a cikin kwakwalwar da ikon motsawar yanayin muhalli, (alal misali, haske) kuma yana isar da bayanai zuwa bincike na karin a cikin gabobi daban-daban.
Bugu da ƙari, kowane tantanin halitta a cikin jiki yana ƙunshe da agogo na kansa wanda yake sarrafa kowace rana tare da karkatar da yawancin kwayar halitta. Duk binciken da akeyi a cikin jiki shine mafi yawan lokuta cikin yanayin daidaituwa, yana bawa tsarin rai damar daidaitawa da yanayinta da kuma ci gaba da daidaita daidaituwar yanayi.
Gwanayen REV-ERB sune manyan bangarorin kayan aikin agogo wadanda suke birkita karfin halittar da kwayoyin cuta ke dogaro dasu, misali, rabe-raben kwayar halitta da narkar da kwayar halitta. Don haka Dokta Panda da abokan aikinsa suka zaɓi bincika ko ƙara ƙarfin wannan tasirin na REV-ERBs (wanda aka fi sani da masu gwagwarmaya na REV-ERB) na iya yiwuwa aiwatar da mugayen ƙwayoyin ƙwayoyin cuta ta hanyar toshe hanyoyin da za su ci gaba da haɓaka.
A cikin gwaje-gwajen gwaje-gwaje, manazarta sun gano cewa masu gwagwarmaya guda biyu na REV-ERB sun kashe nau'o'in ƙwayoyin cuta masu ƙima (ƙididdige hankali, mazauni, da ƙirji), duk da cewa ƙwayoyin suna da canje-canje na gado daban daban waɗanda ke haifar da ci gaban cuta. 'Yan agonists na REV-ERB ba su kashe ƙwarin gwiwa ko ƙwayoyin fata ba, ya zama haka ne yadda yake.
Wadannan binciken sun ba da shawarar cewa za a iya amfani da magungunan da ke yin tasiri na REV-ERBs don magance nau'ikan nau'ikan cutarwa, manazarta sun fayyace.
Masu bincike suna kirkirar kwayoyi wadanda suke farawa ko dakile wasu bangarorin agogo, kuma ana iya tunanin cewa hada-hada iri daban-daban akan magunguna ko kuma maida hankali kan magunguna tare da nau'ikan magani na iya inganta tasirin cutar kansa. A kowane hali, a yanzu, akwai yawan tambayoyin da yawa fiye da amsoshi.
