Jami'ar Texas MD Anderson Ciwon daji da kuma Takeda Kamfanin Magani Iyakance sun shigar da taƙaitaccen fahimta da izinin bincike don haɓakawa da kasuwa mai karɓar maganin antigen da ke ba da umarnin kisa na halitta (CAR NK) – jiyya na tantanin halitta.
A karkashin fahimtar, Takeda zai sami damar zuwa matakin jiyya na MD Anderson don ƙirƙira da tallata magungunan CAR NK-cell har zuwa ayyukan 4, kamar yadda sanarwar da aka yi a ranar Talata 4 ga Fabrairu ta nuna. da kuma sadaukar da kai don haɓaka hanyoyin kwantar da hankali na zamani na gaba, Takeda shine babban abokin haɗin gwiwa don taimakawa ƙungiyarmu ta haɓaka hanyoyin kwantar da hankali na CAR NK ga marasa lafiya da ke buƙatar jiyya, ”in ji Katy Rezvani, MD, PhD, farfesa na dasawa da kuma salon salula. da MD Anderson.
Maganin yana da kwatancen kwatankwacin maganin CAR T-cell, wanda ke nuna babban garanti a cikin cututtuka da yawa, ta hanyar tattara wasu farantin platelet na marasa lafiya, shirya su da masu karɓa na sama don mai da hankali kan girman batun, kuma daga baya sanyawa su sake a cikin haƙuri da jini.
Be that as it may, chemotherapy may leave a few patients without adequate autologous T cells in their blood for treatment with TAR CAR treatment, while others might not have the opportunity that is required for a lab to create enough T cells, as indicated by the analysts.
Abincin NK-cell na abin hawa, wanda aka kirkira a MD Anderson, yana amfani da ƙwayoyin zartarwa na yau da kullun daga jinin igiya. Hasungiyar ta ce tana ba da izini ƙirƙirar maganin da ba ya buƙatar yin al'ada ga kowane mai haƙuri - kuma ƙari ga ƙarin yuwuwar haɗuwa tare da cuta, wanda haɗari ne tare da wasu nau'ikan T-cell.
Ƙungiyar MD Anderson ta yi amfani da retrovirus don kawo sababbin halaye a cikin ƙwayoyin NK: CD19 an ƙara shi don faɗaɗa bayanin CAR NK don ƙwayoyin cuta na B-cell; ana kara interleukin 15 (IL15) don zana halin yanzu na wayoyin da ke cikin jiki; da CASP9 na tushen "ingancin kashe kansa" a matsayin nau'in ma'auni na tsaro, wanda za'a iya kunna shi don haifar da apoptosis ta ƙananan dimerizers atom idan akwai inganci mai guba bayan ƙaddamarwa.
A cikin bayyana fahimtar, MD Anderson da Takeda sun jaddada cewa za a iya tsara maganin kashe-kashe CAR NK a wuraren jinya.
Har zuwa yanzu, maganin ya nuna lafiya: Gwajin ci gaba na I / 2a na asibiti a cikin marasa lafiya tare da koma baya da cutar B-cell mai girman kai ya nuna cewa CD19 CAR NK-jiyya ba ta da alaƙa da matsanancin matsalar fitowar cytokine ko cutar neurotoxicity da aka gani tare maganin CAR-T na yanzu.
Takeda ya ce suna da niyyar fara bincike mai mahimmanci game da maganin CD19 CAR NK-cell a 2021.
Kuna so karanta: CAR-NK Ciwon ƙwayar cuta
MD Anderson ya sami wani kaso kai tsaye wanda taron bai bayyana shi ba a matsayin wani bangare na tsarin, kamar yadda aka tanada masarautu akan yiwuwar cinikayya, kamar yadda sanarwar ta nuna.
Rezvani ya ce makasudin shine a samar da hanyoyin kwantar da hankalin marasa lafiya da kuma sauya rayuwa.
Rezvani ya ce "Maganinmu shine inganta hanyoyin da ake amfani da su ta hanyar haɓaka CAR NKs masu sulke waɗanda za a iya gudanar da su a cikin wani wuri a waje, da ba da damar ƙarin marasa lafiya da za a bi da su yadda ya kamata, da sauri, kuma tare da ƙarancin guba," in ji Rezvani.
