NK Cell immunotherapy a Indiya
NK Cell immunotherapy a Indiya ana ba da shi ta wasu kamfanoni da asibitoci a yanzu. NK Cell immunotherapy don maganin ciwon daji mai maimaitawa da hadaddun yana samun shahara a rana. Ƙarin ƙarin marasa lafiya yanzu sun kasance kwanaki masu zuwa don maganin rigakafi. An gano maganin NK Cell yana da tasiri sosai a ƙarshen matakin maganin ciwon daji. Don haka marasa lafiya waɗanda suka shiga matakin ƙarshe na ciwon daji na iya gwada wannan maganin. NK Cell therapy a yanzu yana cikin India. Kun san cikakkun bayanai game da magani da farashi ku kira mu a + 91 96 1588 1588 ko rubuta zuwa kansarfax@gmail.com.
Kwayoyin rigakafi
Bayan dubban shekaru na juyin halitta, jikin dan adam ya samar da tsarin tsaro na zamani, ya kafa wata runduna mai karfi ta rigakafi, ta tanadi manyan sojoji masu yawa, kuma koyaushe yana kare mu daga harin kansa. Kashin kasusuwa shine tushe na Immune Corps. Anan, ƙwayoyin sel na hematopoietic sun bambanta zuwa mayaƙan rigakafi daban-daban tare da ayyuka daban-daban. Suna da nasu yankin sojojin da alhakin aiki. A halin yanzu runduna uku na garkuwar jiki da na karkashinsu sune kamar haka;
1. Core Corps: Lymphocytes
T-lymphocytes, lymphocytes masu dogara da thymus, sune manyan lymphocytes a cikin jini da sake sakewa
B-lymphocytes: Kwayoyin da ke tasowa a cikin bursa ko kwatankwacinsa (marrow kashi). Suna iya bambanta zuwa ƙwayoyin plasma waɗanda ke samarwa kwayoyin cutar lokacin da ya motsa ta maganin rigakafi.
Kwayoyin NK, sel LAK ba sa buƙatar tasirin kashe-kashen antigen.
2. Legion Auxiliary: Antigen Presenting Cell
Monocyte-macrophage phagocytosis da sakamako na kisa, antigen TD yanzu, fara amsawar rigakafi, tasirin ƙwayar cuta, ɓoye mai shiga tsakani na rayuwa.
Kwayoyin DC rukuni ne na sel daban-daban tare da mafi ƙarfi maganin rigakafi aikin gabatarwa, kuma sune kawai sel masu gabatar da antigen na cikakken lokaci waɗanda zasu iya kunna sel T na asali.
3.Sauran rundunonin garkuwar jiki
Neutrophils, eosinophils / basophils da mast cells, platelets, jan jini.
Menene ƙwayoyin NK?
Kwayoyin Whistler-NK a cikin tsarin rigakafi
Yakin rigakafin da ke jikinmu daidai yake da yakin makiya da aka nuna a fim din. Yana buƙatar rundunonin uku da su rarraba ayyukansu a fili, su tsara shirin yaƙi, kuma su yi aiki tare don halaka abokan gaba.
A cikin yaƙi da ƙwayoyin cutar kansa, ƙwayoyin NK sune mafi kyawun “mai ɓoyewa”.
It not only bears the brunt, it is the first to reach the tumo microenvironment to directly kill cancer cells, and it also sounds the horn of war, secretes secret weapon chemokines, and recruits dendritic cells (CD103 + DC), which is equivalent to telling other immune legions in the body Come and cooperate. The activated dendritic cells then carry tumor antigens to the lymph nodes, presenting the characteristics of the cancer cells to the killer T cells. T cells rushed to the battlefield to kill cancer cells with NK cells.
Menene NK Cell therapy?
Cikakken sunan NK Kwayoyin Killer Kwayoyin Halitta (NK), kuma rukuni ne na uku na lymphocytes waɗanda aka ɗaure da ƙwayoyin T da B a cikin rundunonin tantanin halitta. Kwayoyin NK sun kasance a cikin jinin mutum kuma sune "masu amsawa na farko". Kamar wani jami'in sintiri ne wanda ya kasance yana aiki a cikin jiki. Yayin da jini ke gudana, yayin sintiri, ƙwayoyin NK suna ci gaba da tuntuɓar wasu sel. Da zarar an sami rashin daidaituwa a cikin jiki nan da nan a zubar da kwayoyin halitta. Sun kai hari tare da fitar da kwayoyin cytotoxic da ke dauke da perforin da granzyme a kan membrane cell da aka yi niyya kafin a tura kwayoyin T, suna haifar da kwayoyin cutar kansa zuwa lalata kansu. Har ila yau, suna kawar da kwayoyin cutar kansa da ke yawo da kuma taimakawa wajen hana metastasis.
Na farko, shi ne tsarin garkuwar jikin ɗan adam. Tabbas jarumi ne yana gaba. Kusan duk ƙwayoyin ƙari za a kai hari daga ƙwayoyin NK da aka fi so.
Na biyu, "mai ɓoyewa" a cikin tsarin rigakafi yana da ra'ayi na lokaci akan halin da ake ciki. Da zarar an samo "halin maƙiyi", da sauri "ya ba da rahoto" kuma ya fara aikin kariya na rigakafi da kuma kashe kashe na rigakafi na dukan tsarin rigakafi.
Na uku, yana da tasirin antitumor mai faɗi mai faɗi, baya buƙatar takamaiman takamaiman ƙari, kuma ba'a iyakance shi ta hanyar manyan ayyukan hanawa na histocompatibility (MHC) akan saman tantanin halitta. Lokacin farawa shine mafi sauri, kuma ƙwayoyin T suna buƙatar yin gwajin antigen kafin su iya bambanta "maƙiyi da maƙiyi".
Saboda haka, sakamakon kashe kansa yana da ƙarfi.
Manyan hanyoyin kashe kansa guda uku na ƙwayoyin NK
Kwayoyin NK suna taka muhimmiyar rawa a cikin layin farko na kariya daga ciwon daji. Kwayoyin NK suna da tasirin anticancer guda uku:
Na farko, kashe ƙwayoyin tumor kai tsaye. Kashe ƙwayoyin tumo ta hanyar post-perforin da granzymes ko ta hanyar masu karɓar mutuwa;
Na biyu, ta hanyar ɓoyewar cytokines da chemokines don taka rawar tsarin tsarin rigakafi, kunna ƙwayoyin T da sauran tasirin kashewa;
Na uku, an kafa tasirin ADCC (tasirin cytotoxic mai dogara da antibody). Lokacin da tantanin B ta gano kwayar cutar kansa, za ta bar takamaiman IgG antibody akan kwayar cutar kansa a matsayin alama don tunatar da ƙwayoyin NK. Lokacin da suka ga wannan alamar tantanin halitta NK, sai su ga daya ya kashe daya. Tare da taimakon macrophages da ƙwayoyin B, halin kashe kansa ya karu sosai.
Kuna so karanta: T Cell da NK Cell therapy a Indiya
NK rigakafin rigakafin kwayar halitta
Kodayake suna iya yin sauri da sauri da kuma kai farmaki kai tsaye ga ƙwayoyin tumor, adadin ƙwayoyin NK a cikin jikin ɗan adam kaɗan ne, suna lissafin kashi 10% na farin jini. Kuma binciken ya gano cewa bayan shekaru 25, mutane sun rage rigakafi tare da rage yawan kwayoyin NK. Lambobi da ayyukan ƙwayoyin NK a cikin marasa lafiya na ciwon daji da marasa lafiya bayan ciwon daji sun canza zuwa wani matsayi, kuma ba za su iya taka rawar gani ba wajen yaki da ciwon daji.
Researchers are now developing multiple methods to release NK cell activity against tumors, thereby increasing the efficacy and specificity of NK cell-based therapies. At present, there are three main types of NK cell strategies for tumor immunotherapy a duniya.
01.In vitro kunna autologous ko allogeneic NK cell far
A halin yanzu, mayar da hankali na gida da na duniya kan "ƙwaƙwalwar" NK cell far shine tattara kwayoyin NK daga masu ba da gudummawa masu dangantaka da kuma shigar da su cikin marasa lafiya. Wannan ya tabbatar da cewa yana da aminci, kuma ba kamar maganin T-cell ba, ƙwayoyin NK ba sa haifar da cuta-da-baki a cikin kyallen takarda masu karɓa.
02. Haɗuwar ƙwayoyin NK da ƙwayoyin rigakafi na monoclonal (kamar masu hanawa na rigakafi) don haifar da cytotoxicity na musamman na antibody.
Haɗa maganin binciken bincike tare da sauran maganin rigakafi na NK na iya kaiwa nau'ikan ciwace-ciwace da yawa waɗanda a halin yanzu ba sa amsa hanyoyin kwantar da hankali.
Kodayake tsarin kashe ƙwayoyin NK game da ciwace-ciwacen daji ba takamaiman ba ne kuma baya dogara da sanin antigens masu alaƙa da ƙari, akwai kuma hanyoyin kunnawa ko hanyoyin hana wuraren bincike na rigakafi. Ligands waɗanda ƙwayoyin tumor za su iya bayyana akan wuraren bincike na rigakafi na NK na iya hana ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta NK. Don haka, don iyakance wannan hanawa, a halin yanzu ana haɓaka jerin wuraren bincike na rigakafi na rigakafin ƙwayoyin cuta-NK.
Irin su cetuximab a kan EGFR, cetuximab na iya kunna tasirin ADCC na ƙwayoyin NK kuma ya fara amsawar rigakafi na ƙwayoyin NK.
In addition, studies have found that PD-1 in NK cells is highly expressed in several cancers, including head and neck cancer, thyroid cancer, Hodgkin’s lymphoma (HL), digestive tract cancer (esophageal cancer, liver cancer, colorectal cancer, gastric cancer and biliary cancer ), Breast cancer, Kaposi’s sarcoma, renal cell carcinoma and multiple myeloma. Recent studies have shown that when PD-L1-negative tumors respond to anti-PD-L1 treatment, this effect may be mediated by PD-L1 + NK cells. PD-L1 + NK cells treated with anti-PD-L1 showed enhanced activation and effector function.
03.Gina CAR-NK cell immunotherapy
Chimeric antigen receptor-gyaran NK Kwayoyin: na iya inganta sosai
e ƙayyadaddun ingancin NK cell. Wannan ra'ayin yayi kama da ginin CAR-T: CAR ya haɗa da yankin ganewa na waje (kamar scFv) don gane takamaiman antigens na ƙari; yankin transmembrane, da yanki mai siginar intracellular (sarkar CD3ζ) na iya haifar da ƙwayoyin NK.
Wadanne marasa lafiya ne suka fi dacewa don NK Cell therapy?
A halin yanzu, an yi nazari sosai a cikin gida da na waje NK cell immunotherapy. Kwayoyin NK na cikin gida da na Jafananci an fi niyya da su a cikin ciwace-ciwacen ciwace-ciwace, yayin da maganin NK na Amurka ya fi niyya kan ciwace-ciwacen jini.
Immunotherapy na salula na iya yin daidai da kowane mataki na ciwon daji, kamar:
1. Marasa lafiya da ke fatan yin amfani da maganin rigakafi na salula don inganta rigakafi, cire ragowar kwayoyin cutar kansa, hana sake dawowa, da kuma tsawaita rayuwa bayan cirewar raunuka.
2. Bayan radiotherapy da chemotherapy, marasa lafiya da ƙananan rigakafi da kuma bayyanar cututtuka (kamar asarar ci, tashin zuciya, asarar gashi, kumburin fata, da dai sauransu) ana sa ran zai kara yawan tasirin chemoradiotherapy.
3. Marasa lafiya waɗanda ke jin tsoron tasirin tasirin rediyo da chemotherapy kuma suna fatan yin amfani da hanyoyin jiyya daban-daban don cimma tasirin magani.
4. Marasa lafiya da ke fama da ciwon daji na ci gaba sun bazu ko'ina cikin jiki, amma marasa lafiya da hanyoyin maganin al'ada sun kasa yin hakan, suna tsammanin tsawaita rayuwa da inganta rayuwa.
Mahimman bayanai: Immunotherapy na salula ba shi da wani tasiri mai tasiri akan raguwar ciwace-ciwacen daji a cikin marasa lafiya da ciwon daji. Tasiri ga marasa lafiya da ciwon daji mai ci gaba shine kiyaye ingancin rayuwa da tsawaita rayuwa. Mafi dacewa da maganin rigakafi na salula shine bayan tiyata. A matsayin maganin adjuvant bayan tiyata, don kawar da sake dawowa da kuma kula da maganin da wuri na marasa lafiya da ciwon daji na farko-zuwa-tsakiyar; hade tare da chemotherapy, magungunan da aka yi niyya, masu hana PD1 da sauran jiyya, sakamakon zai fi kyau.
Immunotherapy na salula bai dace da duk masu ciwon daji ba. Kamar sarcoma da Wei Zexi ke fama da shi, ƙwayar cuta ce da ba kasafai take da muni ba. A halin yanzu babu magani mai kyau a duniya. Don haka, immunotherapy ta salula ba ta dace da dabi'a ba. . Don haka, da fatan za a tabbatar da cewa ku, danginku, da abokanku kun yi nisa daga bayanan karya a Intanet. Kafin ka zaɓi karɓar magani, dole ne masana su tantance ku a asibitin ciwon daji na yau da kullun kuma mai iko. Bugu da kari, farashin maganin rigakafi na salula yana da tsada sosai, ba kowane Iyali bane ke iya karban sa. Dole ne kowa ya zaɓi a hankali bisa ga yanayin tattalin arzikin iyali.
Ko da ba za ku iya karɓar waɗannan jiyya na ci gaba ba, bai kamata kowa ya sami motsin rai mara kyau ba. Ina jin cewa an shirya waɗannan sababbin fasahohin don masu arziki, kuma talakawa dole ne su jira mutuwa lokacin da suka kamu da cutar kansa. Tabbas wannan tunanin ba shi da kyau. Dukanmu mun san cewa kyakkyawan hali shine makamin da ya fi dacewa don kayar da ciwon daji. Yawancin majiyyata sun sauƙaƙa kowane irin aiki da matsi na rayuwa bayan fama da ciwon daji, sun kawar da ƙiyayyarsu ga wasu mutanen da ke tare da su, sun koyi gafartawa, sun koyi godiya, kuma sun canja salon rayuwarsu gaba ɗaya. Cin abinci mai kyau, motsa jiki na yau da kullun, aiki akai-akai da hutawa, da daidaita tunanin ku kuma na iya samun tsawon rayuwa, wanda ke da mahimmanci.
Wadanne asibitoci ne ke ba da maganin NK Cell a Indiya?
NK Cell therapy fasaha ce ta tantanin halitta kuma wannan kamfanoni ke bayarwa. A halin yanzu akwai kamfani ɗaya da aka amince da shi wanda ke ba da NK Cell therapy a Indiya. Don cikakkun bayanai kan cancantar haƙuri na NK Cell therapy da fatan za a kira a + 91 96 1588 1588 ko aika rahoton likita ga marasa lafiya kansarfax@gmail.com.
Mafi kyawun likita don NK Cell therapy a Indiya
Kamar yadda aka ambata a baya NK cell far a Indiya ana ba da su ta hanyar kamfanonin maganin tantanin halitta kuma suna da ƙungiyar likitocin da ke kula da lafiyar marasa lafiya yayin jiyya.
Menene farashin NK Cell therapy a Indiya?
Kudin maganin NK cell a Indiya ya dogara da nau'i da girman ciwon daji a cikin majiyyaci. Koyaya don tunani Kudin NK Cell far a Indiya na iya bambanta tsakanin $9000-12000 USD.
Menene hanya don NK Cell therapy a Indiya?
Tsarin tsari da adadin jiko ya dogara da mutum zuwa mutum da girman & nau'in ciwon daji. Da fatan za a aiko da rahoton likita zuwa imel ɗin da ke ƙasa da lambar WhatsApp kuma za mu dawo tare da tsarin kulawa na musamman.
Don sanin game da NK Cell therapy kira + 91 96 1588 1588 ko aika rahoton likita zuwa ga majiyyaci kansarfax@gmail.com.