ಮಾರ್ಚ್ 2023: CAR-T-cell therapy is a novel and effective cancer treatment modality that has revolutionized the treatment of cancer, particularly blood cancers. This therapy achieves a therapeutic effect or cures disease by repairing or reconstructing genetic materials that have been damaged. Since Roseberg first isolated tumour-infiltrating lymphocytes (TILs) to treat melanoma in 1986, the development of modified T cell therapy has gained significant momentum. Since the FDA approved the first CAR-T ಚಿಕಿತ್ಸೆ, Kymriah, in 2017, the CAR-T market has grown rapidly. According to Frost & Sullivan, the global CAR-T market size is projected to increase from USD 10 million in 2017 to USD 1.08 billion in 2020, and then to USD 9.05 billion in 2025, with a compound annual growth rate (CAGR) of 55% from 2019 to 2025, making it the fastest-growing segment of the global cell and gene therapies (CGT) market.
CAR-T therapy is one of CGT therapy’s subsegments. On the basis of the origin of T cells, CAR-T therapy can be divided into two categories. Autologous CAR-T-cell therapy, which employs the patient’s own immune cells, and allogeneic CAR-T-cell therapy, which employs T cells from donor blood or occasionally umbilical cord blood,. The majority of CAR-T therapies are autologous CAR T-ಕೋಶ ಚಿಕಿತ್ಸೆಗಳು, which typically involve the steps outlined below:
ನೀವು ಓದಲು ಇಷ್ಟಪಡಬಹುದು: ಚೀನಾದಲ್ಲಿ CAR T ಸೆಲ್ ಥೆರಪಿ
1) T ಜೀವಕೋಶಗಳನ್ನು ರೋಗಿಯ ಬಾಹ್ಯ ರಕ್ತದಿಂದ ಕೊಯ್ಲು ಮಾಡಲಾಗುತ್ತದೆ;
2) Viral vectors such as AAV then modify T cells with CAR genes that are directed against a specific cell-surface protein on cancer cells;
3) The modified CAR-T cells population is expanded according to the patient’s weight;
4) The expanded CAR-T cells are then reinfused back into the patient. The entire manufacturing procedure lasts between one and three weeks and requires GMP compliance in an ultra-clean environment.
CAR-T therapy has reached a level of success that has never been seen before in treating B-cell cancers that are resistant to or refractory to chemotherapy, including R/R, B-ALL, NHL, and MM. The effectiveness of treating solid tumours is also currently under investigation. CD19-targeting and BCMA-targeting CAR-T therapies achieve the greatest clinical success among all CAR-T therapies. Four of the six CAR-T therapies approved by the FDA target CD19, while two target BCMA.
The most significant advantage over small and large molecule drugs is that patients can replace lifelong treatment of chronic disease with a limited number of doses, or even just one.
The United States pioneered the development of the CAR-T industry. However, by the middle of the 2010s, China had learned quickly and was catching up to the United States. Principally, the key drivers can be attributed to the Chinese government’s support for the development of a CGT ecosystem comprised of biotech companies, academics, healthcare providers, investors, and the government. Following the prioritization of biotechnology in the thirteenth five-year plan, the Chinese government emphasized its strategy to accelerate the innovation and development of biotech industries, including cell therapy. In addition, pertinent ministries have issued encouraging action regulations.
2015 ರಲ್ಲಿ ಔಷಧಗಳು ಮತ್ತು ವೈದ್ಯಕೀಯ ಸಾಧನಗಳ ಮೌಲ್ಯಮಾಪನ, ವಿಮರ್ಶೆ ಮತ್ತು ಅನುಮೋದನೆ ವ್ಯವಸ್ಥೆಯ ಸುಧಾರಣೆಯ ಕುರಿತು ರಾಜ್ಯ ಮಂಡಳಿಯ ಅಭಿಪ್ರಾಯಗಳನ್ನು ಪ್ರಕಟಿಸಿದ ನಂತರ, ಬಂಡವಾಳ ಮಾರುಕಟ್ಟೆಯು ಸಹ ಸಕ್ರಿಯವಾಯಿತು. 45%ನ ಸಂಯುಕ್ತ ವಾರ್ಷಿಕ ಬೆಳವಣಿಗೆಯ ದರದಲ್ಲಿ, ಚೀನೀ ಸೆಲ್-ಥೆರಪಿ ಕಂಪನಿಗಳು 2.4 ಮತ್ತು 2018 ರ ನಡುವೆ ಸುಮಾರು USD 2021 ಶತಕೋಟಿ ಹಣವನ್ನು ಸಂಗ್ರಹಿಸಿವೆ.
ನೀವು ಓದಲು ಇಷ್ಟಪಡಬಹುದು: ಚೀನಾದಲ್ಲಿ CAR T ಸೆಲ್ ಚಿಕಿತ್ಸೆಯ ವೆಚ್ಚ
The number of CAR-T therapy trials in China surpassed those in the United States by 2018 as a result of this thriving ecosystem. As of June 2022, Chinese companies had conducted 342 clinical CAR-T trials. Malignancies in the B lineage were among the most prevalent manifestations. Two ಕಾರಿನಂತಹ ಟಿ products have commercial applications: ಯೆಸ್ಕಾರ್ಟಾ in June 2021 and ರೆಲ್ಮಾ-ಸೆಲ್ in September 2021, among numerous drug candidates.
ಫ್ರಾಸ್ಟ್ & ಸುಲ್ಲಿವಾನ್ ಪ್ರಕಾರ, ದೇಶೀಯ CAR-T ಮಾರುಕಟ್ಟೆಯು 0.2 ರಲ್ಲಿ CNY 2021 ಶತಕೋಟಿಯಿಂದ 8 ರಲ್ಲಿ CNY 2025 ಶತಕೋಟಿಗೆ ಮತ್ತು ನಂತರ 28.9 ರಲ್ಲಿ CNY 2030 ಶತಕೋಟಿಗೆ 45 ರಿಂದ 2022 ರವರೆಗೆ 2030% ನಷ್ಟು CAGR ನಲ್ಲಿ ಹೆಚ್ಚಾಗುತ್ತದೆ ಎಂದು ನಿರೀಕ್ಷಿಸಲಾಗಿದೆ. ಚೀನೀ CAR-T ಮಾರುಕಟ್ಟೆಯು ಇನ್ನೂ ಶೈಶವಾವಸ್ಥೆಯಲ್ಲಿದೆ ಎಂಬ ಅಂಶವು ದೃಢವಾದ ಚಾಲನಾ ಶಕ್ತಿ ಅಸ್ತಿತ್ವದಲ್ಲಿದೆ.
Although the two approved CAR-T products are from Sino-US joint ventures Fosun Kite and JW Terapeutics, domestic players have made breakthroughs and caught up to global players in recent years. Legend Biotech, IASO Biotherapeutics, and CARsgen Therapeutics all obtained NDA approval for their BCMA CAR-T products, establishing them as the leaders in BCMA CAR-T therapy. CD19 CAR-T products are a focus for Juventas Therapeutics, Gracell Biotechnologies, Hrain Biotechnology, ImunoPharm, Shanghai Cell Therapy Group, and numerous domestic companies. Juventas Therapeutics is the leader in Chinese CD19 CAR-T ಚಿಕಿತ್ಸೆ now that the NMPA has accepted its NDA for CNCT19. CARsgen Therapeutics is a global leader in solid tumours, and CT041 is the first CAR-T candidate for treating solid tumours to enter Phase II ವೈದ್ಯಕೀಯ ಪ್ರಯೋಗಗಳು. ಬಯೋಹೆಂಗ್ ಬಯೋಟೆಕ್ ಮತ್ತು BRL ಬಯೋಟೆಕ್ (ಚೈನೀಸ್: ) ಹೊಸ ಅಲೋಜೆನಿಕ್ CAR-T ಮಾರುಕಟ್ಟೆಗಳನ್ನು ಸೃಷ್ಟಿಸುತ್ತದೆ.
ನೀವು ಓದಲು ಇಷ್ಟಪಡಬಹುದು: ಚೀನಾದಲ್ಲಿ ಬಹು ಮೈಲೋಮಾಕ್ಕೆ CAR T ಸೆಲ್ ಥೆರಪಿ
