Masana kimiyya a Jami'ar California, San Francisco sun gano wani direban kwayar halitta na kowa na meningioma mai tsanani, wanda zai iya taimaka wa likitoci su gano wannan ciwon daji mai haɗari da farko da kuma samo sababbin magunguna na waɗannan ciwace-ciwacen ƙwayoyi masu wuyar magani. Wata ƙungiyar bincike da Dokta David Raleigh ya jagoranta ta gano cewa ƙara yawan ayyukan kwayoyin halitta da ake kira FOXM1 da alama yana da alhakin girma mai tsanani, kuma waɗannan ciwace-ciwacen ƙwayoyi suna komawa akai-akai.
To investigate the factors that may lead to aggressive meningioma, Raleigh’s team collected 280 human meningioma samples from 1990 to 2015. Using a range of techniques, including RNA sequencing and targeted gene expression profiling, the researchers searched for links between gene activity and protein production in these ciwan kansa and patients’ clinical outcomes. Finally, a gene called FOXM1 was found to be the core of the growth of invasive meningioma, and also an indicator of the subsequent adverse clinical outcomes, including death.
Masu binciken sun kuma gano wata sabuwar hanyar alaƙa tsakanin yaduwar cutar sankarau da kunna hanyoyin siginar sigina, wanda ake kira Wnt, wanda galibi ke taka rawa a ci gaban amfrayo da samar da nama. Ganin cewa furotin da FOXM1 ya samar na iya watsa sigina tare da hanyar Wnt, sabon bayanan yana nuna cewa aikin haɗin gwiwa na FOXM1 da hanyar Wnt na iya haifar da haɓakar meningiomas mai zuwa. Hypermethylation na iya zama farkon farawa don ƙirƙirar meningiomas mai haɗari.
Raleigh said that future work needs to find out which genes FOXM1 activates to drive meningioma growth, and block these targets with clinical therapies. It is hoped that there will be drugs to stop the pathogenesis of kwakwalwa ƙwayar cuta in this pathway as soon as possible and benefit the majority of cancer patients.
