In the United States, more than 70,000 people are diagnosed with non-Hodgkin’s lymphoma each year, which is caused by excessive proliferation of immune cells in the body’s lymph nodes. The most common is diffuse large B-cell lymphoma (DLBCL), which accounts for about 1/3 of lymphomas, and about half of these tumors are resistant to chemotherapy and immunotherapy. Da zarar lymphoma ya samo asali daga nama na lymphatic, yaduwar kwayar halitta yana haifar da tsarin gaba ɗaya na nama don rushewa, kuma kwayoyin suna nunawa ga sojojin inji irin su kwararar ruwa.
Masu binciken sun binciko yadda wadannan rundunonin ruwa ke da alaka da juriya na ciwace-ciwacen daji, kuma sun samar da na'urar "lymphoma microreactor" wanda ke fallasa lymphoma na mutum zuwa ruwa mai gudana, kama da alamu a cikin tasoshin lymph da wasu ƙwayoyin lymph.
Microreactor na gefen gefen ƙungiyar ya haɗa da ɗakin al'adun tantanin halitta da ke da alaƙa da matsakaicin al'adu (ruwa) ta hanyar kunkuntar tashar juriya, wanda ke jinkirta kwararar ruwa don daidaita tasoshin lymphatic da sassan kumburin lymph. Lokacin gwada nau'ikan nau'ikan nau'ikan lymphoma na DLCBL, ƙungiyar binciken ta gano cewa wasu nau'ikan nau'ikan da aka rarraba bisa ga maye gurbi a cikin ƙwayoyin masu karɓar tantanin halitta da aka samu akan saman tantanin halitta sun amsa daban-daban ga sojojin ruwa. Ƙungiyar ta gano cewa ikon ruwa yana daidaita matakan magana na integrin-adhesin da masu karɓar tantanin halitta B. Akwai tsangwama tsakanin integrin da siginar masu karɓa na cell B, wanda zai iya taimakawa wajen bayyana juriyar wasu ciwace-ciwace.
What is remarkable is that the same tumor subtype responds differently to mechanical forces. If we can understand the role of biophysical stimulation, we can know why some lymphomas are sensitive to treatment, while others are refractory, then we will be able to treat more patients. It is important to understand the factors that regulate B-cell receptor signaling because this pathway is a key target for new therapeutic drugs, and several of them are in clinical trials. Don ƙarin bayani, da fatan za a kira Faxar Cancer.
