A ranar 19 ga Oktoba, 2016, sabon magani Olaratumab ya ba da izinin gaggawa na FDA na Amurka kuma ana iya haɗuwa da doxorubicin don magance takamaiman nau'ikan sarcoma mai laushi (STS) a cikin manya.
m; nade-nade: karya-kalma! mahimmanci; faxa: babu 0px! mahimmanci; “A watan Mayun wannan shekara, FDA ta ba Olaratumab fifikon cancantar bita. An tsara Olaratumab asali don toshe hanyar siginar PDGFRα a cikin ƙwayoyin ƙari da ƙananan mahalli. Dangane da wannan yanayin aikin, Olaratumab ya kuma wuce FDA"maganin nasara" , "Fast Track" da "Magungunan Marayu".
m; nade-nade: karya-kalma! mahimmanci; faxa: babu 0px! mahimmanci; "> Olaratumab wani ɗan adam ne wanda aka samu IgG1 monoclonal antibody wanda ke da babban kusanci ga ɗan adam mai karɓar haɓakar haɓakar haɓakar platelet α (PDGFRα). Wasu binciken sun gano cewa ana samun PDGFRa a cikin nau'ikan nau'ikan nau'ikan nau'ikan ƙwayar cuta, kuma ƙarancin kunna wannan mai karɓar yana da wata alaƙa da ciwace-ciwace. Nazarin preclinical sun yi imanin cewa PDGFRa na iya haɓaka haɓakar ƙwayar cuta da yuwuwar metastatic.
dan dako; dunkule kalma: karya-kalma! imm; faxa: babu 0px! mahimmanci; Olaratumab shine maganin farko na STS bayan an yarda da indosine da radiotherapy fiye da shekaru 40 da suka gabata. Ga waɗannan marasa lafiya, hanyar magani da aka fi amfani da ita ita ce doxorubicin ko Haɗa tare da wasu magunguna.
m; nade-nade: karya-kalma! mahimmanci; faxa: babu 0px! mahimmanci; Gwajin gwaji na asibiti na marasa lafiya 133 tare da STS masu tsattsauran ra'ayi mai ɗauke da nau'ikan nama daban-daban guda 25 sun kimanta inganci da amincin Olaratumab. Sakamakon binciken ya nuna cewa Olaratumab haɗe tare da maganin adriamycin mai wakili guda ɗaya An inganta rayuwar marasa lafiya a cikin rukunin jiyya na adriamycin, tare da rayuwa mai mahimmanci na 14.7 vs 26.5 watanni; tsaka-tsakin ci gaba-free rayuwa na 4.4 vs 8.2 watanni; da ƙari koma baya na 7.5% vs 18.2%, bi da bi.
m; nade-nade: karya-kalma! mahimmanci; faxa: babu 0px! mahimmanci; Jiyya na Olaratumab yana da haɗari na munanan abubuwan da suka faru, gami da halayen jiko da lalacewar tayi- tayi. Abubuwan da ke da alaƙa da jiko sun haɗa da hauhawar jini, zazzabi, sanyi, da kurji. Mafi yawan abubuwan da ke haifar da jiyya sune tashin zuciya, gajiya, da tsaka tsaki Granulocytopenia, ciwon musculoskeletal, mucositis, asarar gashi, amai, zawo, asarar ci, ciwon ciki, neuropathy, da ciwon kai.
