Yanayi na NK cell immunotherapy don ci gaba da ciwon hanta
Mai shekaru 92 mai fama da cutar kansa yana da cikakkiyar gafara
Seven years ago, Ms. M, who was in her 80s, was diagnosed with hepatocellular carcinoma (caused by cancer in the past due to blood transfusion and infection with hepatitis C virus). Because she was in good health at the time, she was successfully surgically removed.
A cikin 2016, ciwon daji ya sake dawowa, amma la'akari da cewa M M ta riga ta tsufa a wannan lokacin, ba a ba da shawarar yin tiyata ba.
Ms. M. was born into a medical family, and her daughter is also a doctor. She consulted on many treatments suitable for mothers other than surgery. Due to the poor location of the tumo, radiofrequency and embolization treatments are not feasible. Among the most cutting-edge radiotherapy methods, the first is to exclude heavy ions, which are not applicable at all, and the second is proton far, kuma karfin jiki na uwa baya iya jurewa. A ƙarshe, wuƙar TOMO ce kawai za ta iya gano ainihin cutar mahaifa. Irradiation.
Doctors suggest that Ms. M should be treated conservatively at such an old age. You can try a mild systemic treatment-NK cell reinfusion to improve immunity without using the toxic and side effects of drug treatment. At the same time, combined with Tom knife radiotherapy to kill ciwon daji.
Babban lokacin kunnawa na sake dawo da kwayar NK cikin jiki shine kwanaki 2-3, don haka Malama M tayi aikin NK a cikin karshen mako bayan maganin rediyo na gida tare da wuka TOMO. Kwayoyin NK zasu iya motsawa tare da jini a cikin jiki duka don cin nasarar haɗin gida da tsarin kulawa tare Ingantaccen sakamako tare da tasirin cutar kansar.
Bayan jiyya, duban dan tayi da gwajin PET-CT sun nuna cewa raunin mai haƙuri yana cikin yanayin tsattsauran ra'ayi. Raunin gida ya ɓace, damuwar mai haƙuri game da cutar ba ta bayyana ba, babu jaundice da ascites, kuma jikin mai haƙuri ya warke a hankali.
NK cell tsarin maganin cutar kansar
NK (natural killer cell, NK) is the immune cell with the strongest anti-cancer effect. The most powerful thing is that it does not require the antigen presentation process and does not require other immune cells to regulate. It can take the initiative, direct, and quickly remove foreign bodies (Virus bacteria infect cells, cancer cells, senescent cells, etc.) Local Fa-rectification.
Although they can quickly defend and directly attack tumor cells, unfortunately, NK cells are only a small part of the immune system, accounting for only 10% of white blood cells. And the study found that after 25 years of age, human immunity declines and the number of NK cells becomes less. The number and activity of NK cells in tumor patients and patients after tumor surgery have changed to a certain extent, and they cannot effectively exert anti-cancer effects..
Masu bincike yanzu suna mai da hankali kan "ƙarfafa" NK cell far- tattara ƙwayoyin NK daga masu ba da gudummawa masu alaƙa da kuma shigar da su cikin marasa lafiya. Wannan ya tabbatar da cewa yana da aminci, kuma ba kamar maganin ƙwayoyin T cell ba, ƙwayoyin NK ba sa haifar da cututtuka-da-baki a cikin kyallen takarda masu karɓa.
Domin inganta aiki da yawan kwayoyin NK a jiki, masana kimiya na kasar Japan sun kirkiro hanyar ninkawa, wanda shine cire 50ml daga jinin mutum, kebe kadan daga kwayoyin NK sannan kuma fadada al'adun don kara lamba zuwa na asali sau 1000, lambar ta kai biliyan 1 zuwa biliyan 5, sannan daga baya ta dawo cikin jiki, adadi mai yawa na kwayoyin NK zasu zagaya sau 3000 zuwa 4000 tare da jini a cikin jiki duka, suna kashe ƙwayoyin kansa, ƙwayoyin tsufa, ƙwayoyin cuta, ƙwayoyin cuta da ƙwayoyin cuta a cikin jiki Har yanzu, don cimma manufar maganin kansar da kansar, inganta rigakafi da tsawanta rayuwa.
A halin yanzu, akwai adadi mai yawa da ke nuna cewa rigakafin rigakafin rigakafi (ƙwayoyin NK) kafin da bayan lokacin tiyata na iya rage haɗarin sake komowa da kuma kamuwa da cutar.
Me yasa masu cutar kansar hanta suka fi dacewa da maganin ƙwayoyin NK
Kwayoyin NK, kamar “Kwayar Halittar Halitta”, suna sintiri cikin jini a ko'ina. Da zarar sun sami kwayoyin halitta na waje ko kwayoyin rikirkita wadanda suka rasa ganewarsu (wanda ake kira MHC), mai karba na kwayar ta NK nan take zai aika da sigina kuma ya hanzarta zuwa ga membrane ɗin da ake so. yakin. Yana fitar da kwayoyi masu guba zuwa gare shi, da sauri ya narkar da kwayoyin halitta, kuma ya sa kwayoyin cutar kansa mutu cikin minti 5.
Ya kamata a sani cewa kwayoyin NK, a matsayin babban ɓangaren tsarin garkuwar jiki, sune mahimman ƙwayoyin ƙwayoyin cuta na cikin jikin mutum, amma ba su da yawa a cikin jinin jikin mutum, wanda yakai 5% -10% na lymphocytes kawai. A cikin hanta, kwayoyin NK suna lissafin 30-50% na lymphocytes.
Idan aka kwatanta da kewaya ƙwayoyin NK, ƙwayoyin NK a cikin hanta suna da halaye masu ban mamaki da halaye na aiki, suna nuna mafi girman ƙwayar cuta zuwa ƙwayoyin ƙari.
During the occurrence of ciwon daji, the proportion of NK cells and the function of cytokines (interferon-γ) production and cytotoxic activity are reduced.
Ta yaya kwayoyin NK suke kashe ƙwayoyin kansa?
Dalilin da yasa kwayoyin NK zasu iya kashe kwayoyin cutar kansa shine saboda daidaitattun siginar masu karɓa da ke aiki da masu karɓa na hanawa a saman ƙwayoyin NK. Ana bayyana ƙwayoyin halittar mai karɓa da ke aiki a saman ƙwayoyin cutar kansa da ƙwayoyin ƙwayoyin cuta kuma ƙwayoyin NK sun gane su. Bugu da kari, kwayoyin cutar kansa da kwayoyin cutar masu cutar galibi suna rasa kwayoyin MHC I, wanda ke sa su zama masu saukin ganewar kwayar NK.
NK cells exist in human blood and are “first responders.”. It is like a policeman who has been on duty in the body. As blood runs around, NK cells continuously contact other cells while patrolling. Once an abnormality is found in the body Cells, immediately stable, accurate, ruthlessly wait for a time to deal with. They attack and release cytotoxic particles containing perforin and granzyme on the target cell membrane before T cells are deployed, triggering the self-destruction of cancer cells. They can also eliminate cancer stem cells circulating in the body and help prevent metastasis.
Fa'idodi na maganin kwayar NK
1. Immune cell therapy is the fourth treatment method after surgery, chemotherapy and radiotherapy. NK cell therapy combined with radiotherapy and chemotherapy can effectively remove tumor cells that cannot be completely removed by surgery;
2. NK cell therapy hade da radiochemotherapy na iya inganta tasirin radiochemotherapy da kuma rage illolin;
3. Ga marasa lafiya masu fama da cutar kansa wadanda basu dace da tiyata ba ko radiotherapy da chemotherapy, maganin kwayar NK shine mafi kyawun zaɓi;
4. Kulawa kai-tsaye tare da kwayoyin NK bayan tiyata na iya hana sake komowa da kuma kamuwa da cutar kansa;
5. Sauke radadin ciwon daji, inganta bacci, inganta ingancin rayuwar masu haƙuri, da fadada zagayen rayuwar masu haƙuri;
6. For sub-healthy people, the use of NK cell therapy can reduce the risk of cancer.
Waɗanne marasa lafiya ne suka dace da maganin ƙwayoyin NK?
Marasa lafiya marasa lafiya kafin a yi musu tiyata, jinkirin murmurewa bayan tiyata, da kuma tsoron ƙwayoyin cututtukan ɓoye ba a kawar da su gaba ɗaya.
Bayan radiotherapy da chemotherapy, rigakafi yayi ƙasa, kuma illolin a bayyane suke (kamar ƙarancin abinci, tashin zuciya, zubewar gashi, kumburin fata, da sauransu), da marasa lafiya waɗanda ke tsammanin ƙara tasirin kimiyyar.
Dangane da tsoron illolin da ke tattare da aikin rediyo da kuma maganin ƙwaƙwalwa, marasa lafiyar da ke fatan yin amfani da magunguna daban-daban don cimma tasirin warkewa.
Kwayoyin sankara a cikin ciwace-ciwacen ci gaba sun bazu cikin jiki, amma hanyoyin jiyya na yau da kullun ba su da ƙarfi, kuma marasa lafiya waɗanda ke tsammanin tsawaita rayuwa da haɓaka ƙimar rayuwa.
NK tsarin kula da ƙwayar salula
1. Yawan jini
Zana 30-50ml na jini gefe o
f marasa lafiya da kuma cire kwayoyin mononuclear;
2. Noman Laboratory
A cikin dakin gwaje-gwaje, gudanar da shigar da kwayar NK da fadadawa har tsawon kwanaki 5-7;
3. Komawa
Bayan an gama al'adar kwayar NK, ana mayar da ita ga mai cutar kansa kamar jiko.
