George D. Demetri da wasu daga Cibiyar Ciwon daji ta Amirka Dana Fabre / Briegen da Cibiyar Ciwon daji ta Mata sun ba da rahoton cewa a tsakanin marasa lafiya da liposarcoma, amfani da iriprine a cikin maganin layi na baya ya inganta ingantaccen rayuwa fiye da dacarbazine. Ga marasa lafiya da ke fama da cutar liposarcoma, abu mafi mahimmanci shi ne zabar maganin iribrin, saboda nau'ikan cututtukan cututtukan suna da iyakantaccen tasiri kan inganci. (J Clin Oncol. Siffar kan layi ta watan Agusta 30, 2017)
Wani gwaji na asibiti na uku na baya ya nuna cewa irribrin idan aka kwatanta da dacarbazine wajen kula da ci gaban liposarcoma ko leiomyosarcoma na iya inganta ingantaccen rayuwa gabaɗaya (OS), kuma halayen mara kyau suna da sauƙin sarrafawa da sarrafawa. Yanzu masu binciken sun gudanar da nazarin karamin rukuni game da halin da kungiyar iribulin da kungiyar dacarbazine take, da nufin fayyace abin da ya dace da lafiyar jiki.
Enrollment conditions: patient age ≥18 years; advanced or advanced liposarcoma that cannot be cured by surgery or radiotherapy; ECOG performance status score ≤2; previous chemotherapy regimens ≥2, including anthracycline. Patients were randomly divided into erebrin group (1.4 mg / m2, d1, 8) or dacarbazine group (850 mg / m2, 1000 mg / m2, or 1200 mg / m2, d1) in a 1: 1 ratio. 21 days is a cycle. Study endpoints include OS, progression-free survival (PFS), and safety.
Sakamakon ya nuna cewa OS a cikin rukunin liposarcoma subgroup an inganta sosai. Tsarin tsakiya a cikin rukunin iribulin da dacarbazine ya kasance watanni 15.6 da watanni 8.4, bi da bi (HR = 0.51, 95% CI 0.35 ~ 0.75; P <001). A cikin rukunin iribulin, marasa lafiya tare da liposarcoma na duk ƙananan sifofin tarihi da marasa lafiya a duk yankuna sun sami ci gaban OS. Matsakaicin PFS na marasa lafiya a cikin rukunin erebrin ya kasance watanni 2.9 da watanni 1.7 dangane da ƙungiyar dacarbazine (HR = 0.52, 95% CI 0.35 ~ 0.78; P = 0.0015). Abubuwa masu rikitarwa sun kasance kama tsakanin ƙungiyoyin biyu.
