Kumburi na yau da kullun abu ne da ke haifar da cutar kansar launin fata, wanda shine na ukun da ke haddasa mace-mace masu alaka da kansa a Amurka. Dokta Anna Means da abokan aiki sun ruwaito a cikin mujallar Cell and Molecular Gastroenterology da Hepatology a watan da ya gabata cewa sun danganta kumburi da ke haifar da ciwon daji na hanji zuwa asarar wani muhimmin furotin mai sigina mai suna SMAD4. SMAD4 yana cikin ɓangaren haɓakar haɓakar haɓakar haɓakar β (TGF-β) hanyar siginar siginar, wanda ke daidaita martanin rigakafi da kumburi ga kamuwa da cuta a cikin epithelium colonic.
Takamaiman sharewar kwayar SMAD4 a cikin ƙwayoyin halittar hanji na yau da kullun waɗanda suka girma a cikin vivo sun haɓaka maganganun masu shiga tsakani. A cikin berayen manya tare da kumburi, rashin SMAD4 yana haifar da kamanceceniya mai ban mamaki tsakanin ciwace-ciwacen daji da cututtukan daji da ke haɗuwa da cututtukan mutum.
Loss of SMAD4 was also observed in 48% of human colitis-related cancers, compared with 19% of scattered ciwan kansa. “This loss may be an important factor from premalignant lesions to aggressive malignant tumors,” the researchers concluded. Therefore, friends with chronic inflammation must eliminate inflammation in time, and do not regret it until the inflammation develops into cancer.
