Wata ƙungiyar bincike daga Cibiyar Ciwon daji ta Abramson (ACC) a Makarantar Magunguna ta Jami'ar Pennsylvania ta gano cewa ko ciwon daji yana da zafi ko sanyi yana samuwa ne ta hanyar bayanan da ke cikin kwayoyin cutar kansa. “Hot” tumors are often considered more sensitive to immunotherapy. In a new study published this week in Immunity, the researchers explored the role of “tumor heterogeneity”, namely the ability of tumor cells to move, replicate, metastasize and respond to treatment. These new findings can help oncologists more accurately tailor the unique tumo composition of patients.
Ben Stanger, farfesa a fannin ilimin gastroenterology da kwayar halitta da cigaban halitta a jami'ar Pennsylvania Perelman School of Medicine, ya ce matakin kwayoyin halittar T da ke kamuwa da ciwace ciwace da ke tattare da kwayoyin halitta. Don ciwace ciwace ciwace, suna buƙatar kaucewa hare-hare daga tsarin garkuwar jiki. Akwai hanyoyi guda biyu: don ci gaba zuwa ciwan sanyi, ko marurai masu zafi waɗanda zasu iya lalata ƙwayoyin T, ta yadda za su iya kare ƙwayoyin tumo daga lalacewar garkuwar jiki.
In this study, researchers found that whether a tumor is hot or cold determines whether it will respond to immunotherapy. Cold tumor cells produce a compound called CXCL1, which can instruct bone marrow cells to enter the tumor, keep T cells away from the tumor, and ultimately make the immunotherapy insensitive. In contrast, knocking out CXCL1 in cold tumors promotes T cell infiltration and sensitivity to immunotherapy.
Teamungiyar ta ƙirƙirar jerin layin ƙwayoyin salula waɗanda suke kwaikwayon halaye na ciwace-ciwacen ƙwayoyin cuta, gami da nau'ikan ƙwayoyin rigakafin da suke ƙunshe. A nan gaba, waɗannan layin ƙwayoyin ƙwayoyin cuta na iya taimakawa ƙarin ganowa da haɓaka magani don takamaiman ƙananan ƙananan marasa lafiya da ke fama da cututtukan cututtukan mahaifa daban-daban.
