Yuli 2021: CAR T-Cell far a cikin m ciwace-ciwacen daji an amince da su a kasar Sin tare da wasu alamomi da alamomi. Kwanan nan, CAR T-Cell far an yi gwajin ciwon daji kamar:
- Ciwon daji na nono
- Ciwon daji na huhu mara-kananan
- Ciwon hanta
- Cholangiocarcinoma
- ciwan kansa
- ciwon ciki
- Ciwon daji na Mammary
- cututtukan hanji
- cutar sankarau
- Oophoroma
- Ciwon ciki na mafitsara
- Ciwon mahaifa
T-Cell CAR akan duk waɗannan cututtukan daji ana amfani da su ga marasa lafiya waɗanda suka koma bayan wasu layukan jiyya kamar tiyata, chemotherapy da radiotherapy.
Shine na farko T-Cell CAR An gano wata yarinya ‘yar shekara 5 mai suna Emily da cutar sankarar bargo a duniya a shekarar 2012.
Jimmy Carter mai shekaru 90, tsohon shugaban kasar Amurka ne ya sanar da hakan melanoma Kwayoyin sun yada zuwa hanta da kwakwalwa.
A ranar 6 ga Disamba, 2015, tare da PD-1 antibody da radiotherapy, ƙwayoyin ciwon daji a cikin vivo sun ɓace.
A ranar 6 ga Maris, 2016, bai sake buƙatar magani don melanoma ba.
A ranar 2 ga Disamba, 2018, ya kuma bayyana a wurin jana’izar tsohon Shugaba Bush.
A ƙarshen 2013, an ƙididdige immunocytotherapy a matsayin ɗaya daga cikin manyan ci gaban fasaha goma na shekara ta mujallar Kimiyya.
A cikin 2014, an gudanar da tarurrukan ilimi na ilimin kansa guda biyu, AACR da ASCO, a Amurka. Immunotherapy ya zama mayar da hankali ga yanke fasaha. A cikin 2014, FDA ta amince da lissafin nivolumab da pembrolizumab.
CAR T Ciwon ƙwayar ƙwayar cuta a cikin ciwon maganin karoid
A cikin 2015, darektan fina-finai Chen Xunqi ya kamu da rashin bambanci thyroid ciwon daji, an yi masa aikin tiyata da chemotherapy da yawa a birnin Beijing, kuma ya daina shan magani;
A cikin 2016, ƙimar PS shine 3 lokacin da yake asibiti, fata, kuma ya yanke shawarar gwada maganin CAR T bayan kwasa-kwasan biyu don yin tumo bace;
A cikin 2017, an gwada shi kuma an sake duba shi, na al'ada; a 2018, an gwada shi kuma an sake duba shi, na al'ada;
Menene CAR T Cell far?
Kwayoyin T suna shiga kyallen ƙwayar cuta, suna ɓoye ƙwayoyin rigakafi na kariya (PD-1, CTLA-4 da sauran ƙwayoyin rigakafi), kuma sannu a hankali suna canza ƙwayar ƙwayar cuta ta gida ta microenvironment.
CAR-T a cikin ƙwayoyin T suna kashe ciwace-ciwacen daji da yana fitar da cytokines don daidaita maganganun MHC da fallasa antigens ƙari. A halin yanzu, rigakafi kewayen rigakafin rigakafin ruwa suna rage tumo.
CAR-T & TIL suna haifar da sakamako mai tarin yawa, suna juya marurai zuwa fagen fama, suna kashe dukkan nau'o'in kwayoyin cuta tare kuma juya su zuwa marurai masu zafi, yana lalata ciwace-ciwacen da samar da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa.
Sakamakon sakamako na maganin C-T-Cell a cikin maganganun ciwon daji mai ƙarfi
Daga cikin marasa lafiya 25 da ke da ciwon daji, 25 sun tafi gwajin CAR T-Cell:
- An samu zazzabi mai zafi a cikin marasa lafiya 6
- dyspnea da alamun ciwon huhu a cikin marasa lafiya 2
- 1 mai haƙuri ya bushe fata da dandruff
- babu wasu marasa lafiya da suka nuna rashin daidaituwa.
Case A: mai cutar kansar huhu yana jurewa CAR T-Cell far
A cikin Nuwamba na 2009, mai haƙuri ya sami ƙwayar huhu na hagu kuma ya shiga hagu na hagu kwayar cutar huhu m tiyata. Pathology: huhu adenocarcinoma;
Daga Jan 2013 zuwa Janairu 2017, metastases na kwakwalwa guda uku sun faru, kuma an ba da tiyata da maganin radiation a jere tare da rashin kulawa;
Daga Maris 2017 zuwa Satumba 2017, don metastases na kwakwalwa, ƙwayoyin mesoCAR-αPD1 da ke bayyana PD-1 antibody an ba su darussan magani shida. Bayan jiyya, an kimanta PR kuma ciwace-ciwacen ciwace-ciwacen sun ragu sosai tare da ɗan ƙaramin ragowar.
Case B: Majinin ciwon daji na Testicular wanda ke jurewa CAR T-cell far
A cikin watan Agusta na 2016, mai haƙuri ya sami taro a cikin ƙwanƙwasa daidai kuma ya yi aikin tiyata. Pathology: amfrayo rhabdomyosarcoma;
A cikin Maris na 2017, bita na PET-CT, ya gano cewa peritoneum, omentum, da hanji ba su da tabbas, la'akari da metastases da yawa a cikin rami na ciki;
Daga Yuni zuwa Satumba 2017, ƙwayoyin mesoCAR-αPD1 waɗanda suka bayyana PD-1 antibody an ba su sau 4. Sakamakon ya kasance CR; duk metastases a cikin ciki sun tafi.
Case C: Mai haƙuri adenosquamous carcinoma na huhu yana karɓar maganin CAR T-Cell
A cikin Nuwamba 2017, an gano cutar sankara na adenosquamous huhu na hagu (6.4 “2.9cm), tare da metastasis na clavicle na hagu da ƙwayoyin lymph na mahaifa biyu. An shigar da shi a asibiti don magani, kuma Ⅲ da V kashi da damuwa na kwakwalwa sun faru bayan 3 chemotherapy , Sakamakon sakamako yana da karfi. Zaɓi gwadawa immunotherapy hade da chemotherapy.
A ranar 2 ga watan Janairu da 6 ga Fabrairu, 2018, an yi allurar rigakafin ƙwayoyin cuta guda biyu, kuma jiki ya inganta sosai, kuma illolin da ke tattare da cutar sankarau ya ragu a hankali. Sake jarrabawa ya nuna babu sake metastasis na ƙari ko karuwa.
Binciken da aka yi a ƙarshen Fabrairu 2018 ya nuna cewa raunin da ke cikin huhun ya ragu sosai kuma tuni an shawo kan cutar kansa.
Case D: An yi wa mara lafiyar ciwon hanta maganin CAR T-cell therapy
A ranar 1 ga Yuni, 2017, an gano ƙwayar cuta mai nauyin 66mm x 46mm a saman ƙarshen huhun lobe na hagu. A ranar 15 ga Yuni, an kwantar da shi a Asibitin tiyata na Hepatobiliary na Oriental domin jinya. Dangane da sakamakon CT-guided huhu huda biopsy, wani tsarin jiyya guda uku-in-daya wanda ya haɗa CAR-T cell immunotherapy, niyya far + chemotherapy an ɓullo da. A ranar 29 ga Yuli, 2017, an yi maganin jiko na ƙwayoyin cuta na farko. Bayan jiko, jiki ya amsa da karfi. Bayan yanayinsa ya kwanta, yanayinsa ya gyaru da farko. Bayan fiye da watanni shida na immunotherapy hade tare da niyya far, ciwace-ciwacen daji a cikin jiki sun kasance mafi ƙanƙanta.
Case E: Wani majinyacin ciwon daji na huhu tare da metastasis na kwakwalwa ya sami maganin CAR T-cell
A ranar 26 ga Nuwamba, 2009, an gano ƙwayar cuta mai tsayi 3.03 “2.39cm a cikin lobe na sama na huhun hagu, kuma an cire lobe na hagu na sama kai tsaye kuma gaba ɗaya a farkon matakin. A ranar 25 ga Janairu, 2013, rashin jin daɗi a cikin ƙananan ƙarshen hagu ya kasa gano ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta a kan allo + maganin da aka yi niyya tare da Iressa. 6 A watan Yunin 2016, wani nau'in takarda, wanda aka inganta ba tare da sabawa al'ada ba ya bayyana a madaidaicin lobe na gaba-parietal na dama don farfadowar kumburin ciki. A cikin 2017, ƙwaƙwalwar ƙwayar cuta Tabarbarewa, wani ƙari mai kusan 3.3 “2.8 cm, ya bayyana a cikin lobe na dama na parietal, kuma an yi metastases na meningeal da yawa da rediyo. 3 A cikin Maris 2017, an fara maganin rigakafi. Sau hudu kafin da kuma bayan jiko, ciwon daji a cikin kwakwalwa ya inganta sosai.
Case F: Mara lafiyan ciwon daji na thyroid wanda ba shi da bambanci ya karɓi maganin CAR T-cell
A cikin 2016, an gano shi da cutar kansa na thyroid. Quine shine mafi munin nau'in cutar kansa, kuma likitoci sun fada cewa watanni 2 ne kawai suka rage. Bayan an yi mata maganin rediyo da yawa, ta yi asarar fam 30, amma jikinta bai inganta ba. Daga baya ta ƙi karɓar magani. Daga baya, na je don gwada rigakafi. Bayan infusions na ƙwayoyin cuta na rigakafi, ƙwayoyin kansar cikin jiki gaba ɗaya sun ɓace.
Case G: Mai ciwon daji na Hypopharyngeal yana karɓar maganin CAR T-Cell
A cikin Yuli 2014, an gano shi tare da ciwon daji na hypopharyngeal, ciwon daji na sacral na layi. Darussan 2 na chemotherapy da tiyatar ciwon daji na hypopharyngeal da rarraba wuyan dama. Bayan shekara daya da rabi, ya sake dawowa, sannan ya ci gaba da aikin rediyo, wanda a lokacin akwai illa a bayyane kuma yanayin jikinsa ba shi da kyau. A ranar 13 ga Janairu, 2016, an karɓi jiko na ƙwayoyin rigakafi guda huɗu a jere. Yanayin ya fara daidaitawa kuma yanayin ya inganta sosai. Daga watan Yuli zuwa Disamba 2016, an sake yin ƙarin jiko na tantanin halitta guda biyar, kuma yanayin jiki ya inganta a hankali, tare da barci na yau da kullum da ci. A cikin hali na inna a gado da dama watanni, da kuma tsokoki a hankali atrophied, nauyi ya karu daga 80 kg zuwa 112 kg.
Case H: Mai ciwon nono na hagu tare da metastasis na kwakwalwa yana karɓar maganin CAR T-Cell
A cikin Janairun 2014, an gano ta da ƙwayar nono mai yaduwa ciwon daji da huhu da hanta metastases. Daga Janairu zuwa Nuwamba 2014, an yi zaman chemotherapy guda 9. Daga watan Yunin 2015, kwayoyin cutar kansa sun koma cikin kwakwalwa, kuma an yi maganin wuka na gamma guda 11, kuma kwayoyin cutar kansa sun bazu gaba daya. 3A cikin Maris 2017, a Hong Kong, an sami PD-1 magani kuma har yanzu ya kasa. Tun daga Afrilu 2018, mun gwada CAR-T immunotherapy. Bayan hanya ɗaya na jiyya, tasirin ya kasance mai ban mamaki. Kumburin kwakwalwa da hanta sun bace. Kumburin da ya bazu cikin huhu ya watse kawai. Rage zuwa 1.2.
