According to the latest clinical data, a single pre-genome test is more effective for Lynch syndrome in patients with colorectal cancer (CRC) than traditional multiple sequential testing methods. The researchers say that providing such advanced genetic testing at the time of diagnosis can help guide and speed up treatment decisions for many CRC patients, and at the same time confirm the diagnosis of patients who may have Lynch syndrome (prone to cancer). When a mutation occurs in one of the DNA repair genes of a person, a carcinogenic situation occurs. People with Lynch syndrome are more likely to suffer from CRC, cutar sankarar mahaifa, ovarian cancer, stomach cancer, or other cancers than the general population.
For this study, the researchers wanted to know whether a single test to screen multiple mutations for early-stage tumo sequencing can replace the multiple detection methods currently used to determine whether patients have Lynch syndrome. To this end, the researchers analyzed tumor samples from 419 CRC patients. All study participants analyzed tumor samples using the traditional multiple test genetic test method and a single pre-genome tumor sequencing test. Among them, a single tumor sample analyzed multiple mutation.
Masu binciken sun kwatanta sakamakon hanyoyin binciken biyu kuma sun gano cewa hanyar da aka tsara ta ciwace ciwace a baya ta fi damuwa fiye da tsohuwar hanyar gano abubuwa da yawa kuma tana iya gano cutar Lynch musamman. Shirye-shiryen ciwace-ciwacen wuri ya ƙara yawan gano cutar ta Lynch da 10%, kuma ya ba marasa lafiya mahimman bayanai game da zaɓuɓɓukan magani.
Hanyoyin gwaje-gwajen da suka gabata za su nuna kawai zato na ciwo na Lynch, amma ba tare da ƙarin gwaje-gwaje masu yawa ba, ba za a iya tabbatar da ganewar asali ba, wanda zai jinkirta tsarin ganewar asali kuma ya kara yawan farashi. Wannan sabuwar hanyar ta nuna ainihin maye gurbi a lokacin haihuwar majiyyaci, kuma tana buƙatar gwaji guda ɗaya kawai, ta hanyar yin amfani da gwajin jini, wanda ya fi arha fiye da na'urar gwajin kwayoyin halitta. Hanyoyin da suka gabata wasu lokuta suna buƙatar marasa lafiya suyi gwaje-gwaje daban-daban guda biyar kafin sanin ko suna da cutar Lynch.
Wannan sabuwar hanyar na iya rage tasirin farashi sosai, zai iya tantance sakamakon gwajin daidai, kuma zai iya hana yawancin marasa lafiya masu saurin kamuwa da cutar kansa.
