Wata ƙungiyar bincike a Cibiyar Nazarin Ciwon daji (CSI) ta Jami'ar Ƙasa ta Singapore ta kirkiro wani sabon magani na peptide mai suna FFW wanda zai iya hana ci gaban ciwon hanta (HCC) ko na farko. ciwon daji . Wannan bincike mai ban mamaki yana buɗe kofa don ƙarin ingantaccen maganin cutar kansar hanta da rage tasirin sakamako.
SALL4 is a protein associated with tumor growth and has been used as a prognostic marker and drug target for HCC, lung cancer and leukemia. It is usually present in a growing fetus, but is inactive in adult tissues. In some cancers, such as HCC, SALL4 is reactivated, leading to tumo girma.
Kwayoyin kwayoyi waɗanda ke aiki akan sunadaran, kamar SALL4-NuRD, yawanci suna buƙatar furotin da aka yi niyya don samun ƙaramin “aljihu” a cikin tsarinsa na 3-D, inda ƙwayoyin ƙwayoyi zasu iya wanzu kuma suyi aiki. A cikin binciken farko, an gano cewa furotin SALL4 yana hulɗa da wani furotin NuRD, yana yin haɗin gwiwa wanda ke da mahimmanci ga ci gaban cututtukan daji kamar HCC. SALL4 wanda wannan ƙungiyar bincike ta tsara bai nemi 'aljihu' ba, amma sun ƙirƙira kwayoyin halittu waɗanda ke toshe hulɗar tsakanin SALL4 da NuRD. Bincike ya gano cewa toshe wannan hulɗar na iya haifar da mutuwar ƙwayar ƙwayar cuta da kuma rage motsin ƙwayoyin tumor.
FFW can effectively block protein-protein interactions, and does not require “pockets” to take effect. The research team also found that when combined with sorafenib, FFW can reduce the growth of sorafenib-resistant HCC. Although most niyya hanyoyin kwantar da hankali are small-molecule drugs, well-designed peptide drugs (such as FFW) tend to have higher selectivity than large-molecule surfaces and are less toxic than small molecules.
Masanin binciken kasar Singapore Dr. Liu Bee Hui ya ce: Bisa bayanan da muka samu daga tsari da kuma bayanin kwayoyin halittar duniya, muna ci gaba da yin nazarin wannan peptide da sauran nau'in peptides masu irin wannan tsari, domin a karshe za a mai da su magungunan asibiti da kuma kawo wa marasa lafiya amfani.
