Maganin da ake amfani da shi don shaye-shaye na iya magance cutar kansa ta hanyar kai hari ga macrophages
Wata kungiyar bincike karkashin jagorancin Yuya Terashima daga Jami'ar Tokyo ta gano cewa maganin da ake amfani da shi don shaye-shaye na iya yin magani ciwon daji ta hanyar kai hari ga macrophages.
Bisa kididdigar da WHO da hukumar bincike kan cutar daji (IARC) ta yi, an samu sabbin mutane miliyan 18.1 da kuma mutuwar miliyan 9.6 a shekarar 2018. Daya daga cikin maza 5 da mace daya cikin 6 a duniya na kamuwa da cutar kansa a lokacin rayuwarsu, daya kuma cikin maza 8 da kuma mace-mace. daya daga cikin mata 11 na mutuwa daga cutar. A duk duniya, an kiyasta adadin mutanen da ke raye a cikin shekaru 5 na kamuwa da cutar kansa, wanda ake kira yawan shekaru 5, ya kai miliyan 43.8.
Ciwon daji na huhu shine mafi yawan nau'in ciwon daji a cikin maza (14.5%) kuma mafi yawan sanadin mutuwar maza (22%). Wannan ya biyo baya prostate ciwon daji (13.5%), maganin ciwon daji (10.9%), & ciwon daji (9.5%). Daga cikin mata, ciwon nono ya kai kusan kashi 25%, sai kuma kansar huhu (13.8%), cancer colorectal (9.5%), & cancer cervical (6.6%).
Gina a magani don yaƙi m girma ya kasance ɗaya daga cikin matsalolin da suka fi damuwa a cikin binciken magani. Mummunan girma yana da rashin mutuncin halayensa ga yadda ƙwayoyin cuta ke amfani da tsarin nasu mai juriya don haɓakawa da yaɗuwa, a ƙarshe sun zama mara kyau. Kwayoyin marasa rauni kamar macrophages, waɗanda galibi suna yaƙi don tabbatar da sel na yau da kullun, ƙwayoyin cuta masu haɗari ne ke ba da umarni, kuma suna mamaye duniya kewaye da ciwace-ciwacen daji, suna zama macrophages masu alaƙa da ƙari (TAMs).
A gaskiya, an gano cewa mummunan ƙwayar marasa lafiya ga wanda immunotherapy ba ya da 'ya'ya a gaskiya yana da wadata a macrophages, yana tabbatar da alaƙa tsakanin cutar da TAMs. Wadannan TAMs ne ke samar da sunadaran sunadaran kamar chemokines kuma suna haifar da fitar da wuraren bincike mai hanawa wanda ke haifar da rigakafi. tumo yanayin, wanda ke tabbatar da mummunan ci gaban ƙwayoyin cuta kuma yana ba da damar haɓaka haɓakarsu. Tun da TAMs suna ƙarfafa yada m Kwayoyin girma, sarrafa su a matsayin hanyar magance cututtuka ya ɗauki la'akari tun daga baya.
Wata tawagar bincike daga jami'ar kimiyya ta Tokyo, karkashin jagorancin Yuya Terashima, ta ga wannan a matsayin wata dama ce ta duba fannin samar da sabbin magungunan rigakafin cutar. Aikinsu na asali a cikin Nature Immunology 2005 ya bayyana bayyanar da wani furotin na haƙiƙa mai suna FROUNT, wanda ke da alaƙa da jagorori da haɓaka TAMs. Ta wannan hanyar, FROUNT yana da alaƙa kai tsaye zuwa ka'idodin TAM saboda yana ƙara "siginar chemokine," nau'in sadarwar salula wanda ya zama dole don tattarawa da motsi na TAM.
A wannan lokacin, don rage kowace alamar cututtuka, ƙungiyar ta kuma gina wata dabara mai cin gashin kanta don taƙaita tasirin FROUNT akan motsin chemokine ta hanyar murkushe haɗin gwiwa tsakanin su biyun. Kungiyar ta duba hada-hadar 131,200 tare da mai da hankali kan disulfiram, wani magani da ake amfani da shi don magance shaye-shaye, kuma an yi magana game da yuwuwar sa a matsayin makiyi na rashin kwanciyar hankali. An samo wannan magani don haƙƙin haɗe zuwa shafin FROUNT, yana sa FROUNT ba zai iya samun damar haɗin gwiwa tare da sassan alamar chemokine ba.
Idan aka yi la’akari da sakamakon, Terrashima ya fayyace, “Lokacin da aka gwada kan berayen, disulfiram ya danne ci gaban macrophages kuma ya hana ci gaban ƙwayoyin girma mara kyau. Don haka, bincikenmu ya bayyana sabuwar hanyar magance ciwon daji wanda zai iya dakatar da haɓakar ƙwayoyin cutar kansa waɗanda ke da wuya ga tsarin rigakafi don ganowa lokacin da aka yi amfani da su tare da disulfiram.
Da fatan, za mu sami ganin sababbi hanyoyin kwantar da hankali a cikin maganin ciwon daji.
