Iyini i-MRD ekwelapheni umdlavuza?
Izifo Ezisele Ezilinganisekayo, noma i-MRD, igama lamangqamuzana omdlavuza ambalwa kakhulu ahlala emzimbeni ngemva noma phakathi nokwelashwa. I-Flow cytometry, i-polymerase chain reaction (PCR), noma ukulandelana kwesizukulwane esilandelayo amasu azwela kakhulu angathola lawa maseli omdlavuza ngisho nalapho izindlela zokuxilonga ezijwayelekile, njengezikena zezithombe, zingakwazi.
Ukuqapha i-MRD kubaluleke kakhulu ekunqumeni indlela yokwelapha izinhlobo ezahlukene zomdlavuza wegazi, njenge I-acute lymphoblastic leukemia (YONKE), i-acute myeloid leukemia (AML), i-myeloid leukemia engapheli (CML), i-lymphomas, kanye ne-myeloma eminingi. Kuyasiza ukuthola ukuthi mangakanani amathuba okuthi othile abuye futhi angasetshenziswa ukushintsha izinhlelo zokwelashwa njengoba kudingeka.
Uma othile enomdlavuza, ukuhlolwa kwe-MRD kusetshenziselwa ukubona ukuthi ukwelashwa kusebenza kahle kangakanani kanye nokusiza ukuhlela ukwelashwa okwengeziwe. Isibonelo, uma i-MRD itholakala ngemva kokwelashwa kokuqala, kungase kusho ukuthi umdlavuza awuphenduli kahle ekwelashweni kwamanje futhi kudingeka kwenziwe izinguquko. Uma, ngakolunye uhlangothi, i-MRD iyeka ukutholakala ngemva kokwelashwa, kusho ukuthi umdlavuza awusakhuli nokuthi ukwelashwa kuyasebenza.
To sum up, MRD is an important idea in cancer treatment because it helps figure out how well the treatment is working and helps plan future treatments. It is necessary to keep track of the growth of people with different types of umdlavuza wegazi and can be used to guess how likely it is that the cancer will come back.
Ungahle uthande ukufunda: Ukwelashwa kwe-CAR T-Cell eChina
Itholwa kanjani i-MRD ezigulini ezinomdlavuza?
I-Flow cytometry, i-polymerase chain reaction (PCR), noma ukulandelana kwesizukulwane esilandelayo yizindlela eziqondile ezisetshenziselwa ukuthola Izifo Ezisele Ezilinganisekayo (MRD) ezigulini ezinomdlavuza. Izindlela zendabuko zokuxilonga umdlavuza zingase zigeje inombolo encane kakhulu yamangqamuzana omdlavuza ezingatholwa yilezi zindlela. Ukuhlolelwa i-MRD kubaluleke kakhulu ekugcineni umkhondo wokuthi ukwelapha umdlavuza kusebenza kahle kangakanani nokuhlela ukwelashwa okusha.
Kumathumba aqinile, ukuhlonzwa kwe-MRD kuyadingeka ukuze kutholwe iziguli ezisenezilonda ngemva kokuhlinzwa. Cishe amaphesenti ayishumi kuya kwayi-10 alezi ziguli adinga ukubhekisiswa kabanzi. Kubaluleke kakhulu ukubeka iso ku-MRD kubantu abanomdlavuza wegazi njenge KONKE, i-AML, i-CML, i-lymphomas, ne-multiple myeloma ukuze odokotela bakwazi ukwenza izinqumo mayelana nokwelashwa futhi baqagele ukuthi isiguli sizokwenza kanjani.
Ngokuvamile, ukuthola i-MRD ezigulini ezinomdlavuza kusho ukusebenzisa izindlela zesimanje nezibucayi ukuthola amangqamuzana omdlavuza okungenzeka angatholakali ngezindlela ezindala. Lokhu kulandelela kubaluleke kakhulu ekutholeni ukuthi ukwelashwa kusebenza kanjani nokuthi yiziphi ezinye izinyathelo zokwelapha okufanele zithathwe.
Yiziphi izindlela ezijwayelekile ezisetshenziswa ukuthola i-MRD ezigulini ezinomdlavuza?
Ezinye izindlela ezivamile zokuthola Izifo Ezisele Ezilinganisekayo (MRD) ezigulini ezinomdlavuza yilezi:
1. I-Flow Cytometry: Le ndlela ibheka izici zamaseli kusampula ukuze kutholwe amaseli angajwayelekile angasho ukuthi i-MRD ikhona.
2. I-Polymerase Chain Reaction (PCR): I-PCR iyindlela yamangqamuzana esetshenziselwa ukuthola nokukopisha amaphethini athile e-DNA, evumela ososayensi bathole amanani amancane amangqamuzana omdlavuza kusampula.
3. I-Next-Generation Sequencing (NGS): I-NGS iyithuluzi lokulandelana eliphezulu elingathola izinguquko zofuzo ezixhumene nomdlavuza. Lokhu kusiza ukuthola i-MRD enokuzwela okuphezulu nokucaciswa.
Lezi zindlela zibaluleke kakhulu ekubhekeni iziguli ezinomdlavuza ngesikhathi nangemuva kokwelashwa. Basiza ukuthola ukuthi ukwelashwa kusebenze kahle kangakanani, ukuqagela ukuthi kuzokwenzekani, futhi bahlele ezinye izindlela zokwelapha.
Ungahle uthande ukufunda: Izindleko zokwelashwa kwe-CAR T-Cell e-China
Yini ukubaluleka kwe-MRD ekwelashweni kwe-CAR T Cell?
I-Measurable Residual Disease (MRD) iyingxenye ebaluleke kakhulu Ukwelashwa kwamaseli e-CAR T ngoba kusiza odokotela ukuthi babone ukuthi ukwelashwa kuzosebenza kahle kangakanani nokuthi yimiphi imiphumela ongayilindela. Ucwaningo luye lwabonisa ukuthi ukuqeda i-MRD ngemva kwalokho Ukwelashwa kwe-CAR T-cell can increase the chance of life, especially in people whose MRD response wasn’t as good as it could have been. Researchers are also looking into MRD tests as a way to predict early relapse and see how well treatment is working after Ukwelashwa kwe-CAR T-cell.
Nge-acute lymphoblastic leukemia (ALL), i-MRD isibe umaka obalulekile wokubikezela umphumela wocwaningo kanye nokuthola ukuthi ubani osengozini, ikakhulukazi uma kuziwa ekwelashweni kwe-CAR T-cell. Ukuhlolwa okuhle kwe-MRD ngaphambi kokufakelwa kuye kwaxhunyaniswa nemiphumela engcono yomtholampilo ekwelashweni kwe-CAR-T okulandelwa ukufakelwa kwe-haploidentical hematopoietic stem cell for relapsed or refractory acute lymphoblastic leukemia. Lokhu kubonisa ukuthi kubaluleke kangakanani ukuhlolwa kwe-MRD empumelelweni yokwelashwa.
Sekukonke, ukuhlolwa kwe-MRD kuyingxenye ebalulekile Ukwelashwa kwamaseli e-CAR T ngoba isiza odokotela balandelele ukusabela kokwelashwa, babikezele ukuphinda bagule, futhi benze ngendlela oyifisayo izinhlelo zokwelashwa ukuze bathole imiphumela engcono kakhulu yesiguli ngasinye.
Ungahle uthande ukufunda: Ukwelashwa kwe-CAR T-Cell ye-myeloma eminingi e-China
Ingabe i-MRD ayinayo ibalulekile ngaphambi kokwelashwa kwe-CAR T Cell?
Ukuqeda i-MRD kubalulekile ngaphambi kokwelashwa kwe-CAR T cell ngoba kuboniswe ukuthuthukisa imiphumela yesiguli namazinga okusinda. Ucwaningo lukhombisa ukuthi ukwelashwa kwe-CAR-T kungasusa ngempumelelo i-MRD futhi kwandise ukusinda kubantu impendulo yabo ye-MRD engeyinhle ngendlela ebingaba ngayo. Futhi, ukuba nohlolo lwe-MRD olunegethivu ngaphambi kokufakelwa kabusha kuye kwaxhunyaniswa nemiphumela engcono yomtholampilo ekwelashweni kwe-CAR-T kwe-acute lymphoblastic leukemia ebuyele emuva noma eyekile ukuphendula ekwelashweni. Futhi, uma i-MRD ihlala noma ibuya ngemva kokwelashwa, ingasiza odokotela ukuba baqagele ukuthi iziguli ze-B-cell acute lymphoblastic leukemia zizophinde zibuyele nini. Endabeni ye-myeloma, ukukalwa kwangaphambi kwesikhathi kwesimo se-MRD somnkantsha kuyinkomba enhle yokusinda ekwelashweni kwe-CAR-T. Ngakho-ke, ukuthola i-negative ye-MRD ngaphambili Ukwelashwa kwamaseli e-CAR T kuyingxenye enkulu yokwenza ukwelashwa kusebenze kangcono kanye nokwenza ngcono imiphumela yesiguli.
