Ukukhuluphala ngokweqile kuyanda emhlabeni wonke futhi kuhlobene nesifo somdlavuza wamathumbu , kodwa indlela yakho yokuphila ibiyimpicabadala. Ocwaningweni olusha, ucwaningo lweNyuvesi yaseYale luthole ukuthi ukukhuluphala kuqhuba kanjani ukukhula kwesimila kumagundane futhi lwembula amasu angahle alwe nalesi sifo somdlavuza.
Ithimba lifunde amagundane afakwe ngamamodeli ofuzo ezimila noma umdlavuza wamathumbu. Abacwaningi baqale bafunda umphumela wokudla okunamafutha amaningi kumagundane. Base benikeza amagundane umuthi owodwa wemithi emibili: owodwa kwakuyi-controlled mitochondrial proton mass (CRMP), kanti enye kwakuyi-metformin (umuthi osetshenziswa kakhulu wesifo sikashukela emhlabeni), oshisa amafutha esidakamizwa sesibindi.
The team found that high levels of insulin are the link between obesity and umdlavuza colon. Insulin increases glucose uptake in tumors and promotes isisu growth. The researchers also found that both drugs can reduce insulin levels and slow tumor growth in mice.
Abacwaningi bathi lolu cwaningo lungolokuqala ukukhombisa ukuthi amazinga aphezulu e-insulin enziwa ukukhuluphala aqhuba umdlavuza wekholoni ngokwandisa ukumuncwa kweglucose kulezi zinhlobo. Nakuba ucwaningo olwengeziwe ludingeka ukuze kuqinisekiswe ukuthi lokhu okutholakele kuyasebenza yini kubantu, ukwelashwa kokunciphisa i-insulin: i-metformin, i-CRMP, Futhi ngisho nokuzivocavoca kungasiza ukunciphisa noma ukuvimbela umdlavuza wekoloni.
