Ukwelapha isimila sobuchopho kuhilela izinga eliphezulu lobuchwepheshe nendlela entsha ngobuchwepheshe bamuva nemithi iyadingeka ukuze kuliwe ngempumelelo nalesi sifo esibulalayo. Ucwaningo olusha nendlela yokwelashwa komdlavuza kukhombisa ukuqondiswa kwewashi lebhayoloji yomzimba. Izinhlanganisela ezimbili eziqondise izici zewashi le-circadian zibhubhisa izinhlobo ezimbalwa zamaseli omdlavuza elabhorethri futhi zehlise ukukhula kwesimila sobuchopho kumagundane ngaphandle kokuba nomthelela kumaseli ajwayelekile.
Iwashi le-Circadian
Iwashi le-circadian liyinsimbi yemvelo eyinkimbinkimbi elawula umculo wansuku zonke womzimba womuntu, ngokwesibonelo, ukuphumula, ukushisa komzimba, nokufana. “Iwashi” le-ace liyindawo ebuchosheni enamandla okukhuthaza imvelo, (ngokwesibonelo, ukukhanya) futhi idlulisele imininingwane kumasheke asizayo ezithweni ezahlukahlukene.
Ngaphezu kwalokho, wonke amaseli emzimbeni aqukethe iwashi lawo elilawula usuku nosuku ukunyakazisa kwamandla amaningi wamaseli. Konke ukuhlola emzimbeni kungokwengxenye enkulu esimweni sokuzwana, okwenza ifomu lokuphila likwazi ukuzivumelanisa nesimo salo futhi ligcine ukulingana kwemvelo.
Amaprotheni we-REV-ERB ayizingxenye ezibalulekile zehadiwe lewashi elinciphisa amandla emvelo amangqamuzana ezifo ancike kuwo, ngokwesibonelo, ukwahlukaniswa kwamaseli nokugaywa kwamaseli. Ngakho-ke uDkt. Panda nozakwabo bakhetha ukuhlola ukuthi kuyaqinisa yini ukuthi ama-REV-ERBs (awaziwa njengama-agonists we-REV-ERB) kungenzeka asebenzise amangqamuzana okukhula amabi ngokuvimba amandla okufanele aqhubeke nokukhula.
Kwilebhu uzama, abahlaziyi bathola ukuthi ama-agonists amabili e-REV-ERB abulala izinhlobo ezahlukahlukene zamaseli abulalayo (ukubala ingqondo, ikholoni nesifuba), yize iqiniso lokuthi amaseli ayenoguquko olwehlukanisa amafa oluqhuba ukukhula kwezifo. Ama-agonists e-REV-ERB awabulalanga izingqondo eziqinile noma amangqamuzana esikhumba, kungaba njalo.
Lokhu okutholakele kuncoma ukuthi imishanguzo esebenza ngama-REV-ERBs ngokusobala ingasetshenziswa ukwelapha izinhlobo ezahlukahlukene zobungozi, abahlaziyi bacacisa.
Abaphenyi bakha izidakamizwa eziqala noma ezinqanda ezinye izingxenye zewashi le-circadian, futhi kungenzeka ukuthi ukuhlangana kwamawashi ahlukahlukene okugxile emithini noma ekubhekeni kwewashi emithini enezinhlobo ezahlukahlukene zokwelashwa kungathuthukisa imithelela ye-anticancer. Kunoma ikuphi, njengamanje, kunenani elikhulu lemibuzo kunezimpendulo.
