Ocwaningweni olukhulu kunazo zonke lwe-genome-wide pancreatic cancer kuze kube manje, abacwaningi baseJohns Hopkins Kimmel Cancer Center kanye neNational Cancer Institute nabahlanganyeli kwezinye izikhungo ezingaphezu kuka-80 emhlabeni wonke bathole ukuguqulwa kwezakhi zofuzo ezifundeni ezinhlanu ezintsha zofuzo lomuntu Lokhu kungase kwenyuse ingozi. umdlavuza we-pancreatic.
Lokhu kutholakala kwashicilelwa kwi-Nature Communications ngoFebhuwari 8, kanti ososayensi bahlaziya izinguquko ezingaphezu kwezigidi eziyi-11.3 kubantu abangu-21,536. Lokhu okutholakele okusha kudale esinye isinyathelo sokubamba izinguquko zofuzo ezihambisana nezici zomdlavuza we-pancreatic, ezingayiqonda kangcono i-pathogenesis yomdlavuza we-pancreatic futhi iqondise ucwaningo lwezindlela zokwelashwa ezihlosiwe kakhulu nezindlela zokubona nokuhlola kusenesikhathi. Ukwahlukahluka okusha kwezakhi zofuzo kuma-chromosomes abantu 1 (isikhundla 1p36.33), 7 (isikhundla 7p12), 8 (isikhundla 8q21.11), 17 (isikhundla 17q12), no-18 (isikhundla 18q21.32) kwandisa ingozi yomdlavuza wepancreatic. Ukuba khona kwekhophi ngayinye kulawa ma-genome kwandisa ingozi yomdlavuza we-pancreatic ngo-15-25%.
Ezingeni ngalinye, kukhona ukuguqulwa okungabikezeli ngokuphelele umdlavuza, ngoba kuhlotshaniswa kuphela noshintsho oluncane engozini, kepha uma kuhlangene, kusiza ukuqonda ngokugcwele i-pathogenesis yomdlavuza we-pancreatic. Abaphenyi bazoqhubeka nokuhlola izici zofuzo zomdlavuza wepancreatic, futhi kunezici eziningi zofuzo esingazazi ngengozi yomdlavuza wepancreatic.
Understanding the genetic mutation mechanism of pancreatic cancer can better develop targeted drugs, which will set off a wave of pancreatic cancer treatment. There are many targeted drugs on the market for other cancers. For different types of mutant genes, targeted drugs are used to reduce side effects and improve efficacy. Therefore, it is recommended that cancer patients must pay attention to the benefit space of targeted therapy and conduct genetic testing before medication.
Izinkampani ezinkulu ezinegunya ezingakhetha ukwenza ukuhlolwa kwezakhi zofuzo komdlavuza yi-American Kerrys, American Foundation, kanti ezasekhaya zinePansheng, Shihe Gene. IGlobal Oncologist Network ingasiza iziguli ngokuhlolwa kofuzo kuyo yonke inqubo. Iziguli zingabonisana ne-Global Oncologist Network ukuze zibonisane.
Inkomba: https://medicalxpress.com/news/2018-02-genetic-linked-pancreatic-cancer.html
