IYunivesithi yase-Athens Strati A et al. ibike ukuthi noma ngabe i-PD-L1 idlulele ngokweqile kumaseli ajikelezayo wesimila (CTC) inganikeza ulwazi olunokwenzeka nolubalulekile lokubikezela ezigulini ezinekhanda nentamo i-squamous cell carcinoma. Ngemva kokwelashwa, iziguli ezine-PD-L1 ene-positive ku-CTC ethola ukwelashwa kwe-adjuvant PD1 yokucindezela kufanele zihlolwe okwengeziwe. (U-Ann Oncol. 2017; 28: 1923-1933.)
Based on the tumor’s biological markers, it can be determined whether PD 1 checkpoint inhibitors may ultimately benefit some patients with ikhanda nentamo squamous cell carcinoma. The molecular characteristics of circulating isisu cells are critical for studying targeted therapy of tumors, and the biomarkers that predict PD 1 checkpoint inhibitors are still unclear. This prospective study included a group of patients with head and neck squamous cell carcinoma who were being treated to evaluate whether circulating tumor cells that overexpress PD-L1 can be detected at baseline (before treatment) and at different treatment time points to predict treatment After the clinical effect.
Abacwaningi bathuthukise ikhithi ezwela kakhulu futhi ethize ye-RT-qPCR yokuthola inkulumo ye-PD-L1 mRNA kumaseli e-EpCAM-positive CTC. Ucwaningo lubhalise iziguli ze-113 ezinekhanda elithuthukisiwe lendawo kanye nentamo ye-squamous cell carcinoma futhi ithole inkulumo ye-PD-L1 kumaseli e-EpCAM-positive CTC ekuqaleni, ngemva kwemijikelezo ye-2 ye-induction chemotherapy (amaviki angu-6), nangemva kwe-chemoradiation efanayo (amaviki angu-15) Izinga.
Imiphumela yabonisa ukuthi ekuqaleni, iziguli ezingu-25.5% (24/94) zazine-PD-L1 overexpression kuma-CTC azo. Izinga lokucindezeleka ngokweqile ngemva kwe-chemotherapy yokungeniswa kwaba ngu-23.5% (8/34), kanye nama-22.2% (12/54). Ngemva kokwelashwa, iziguli ezine-CTC ezisakhuluma ngokweqile nge-PD-L1 zazinokusinda okufushane okungenayo inchubekelembili (P=0.001) nokuphila okufushane sekukonke (P<0.001).
Ngemva kokwelashwa, i-PD-L1 ngaphandle kokukhuluma ngokweqile ingase ibe maningi amathuba okuba ithole ukukhululwa okuphelele (OR=16, 95% CI 2.76~92.72; P=0.002).
