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Ukutholakala kwamaprotheni amasha kusiza ekwelapheni nasekuvimbeleni umdlavuza we-pancreatic

Yabelana ngalokhu okuthunyelwe

Ucwaningo olusha luthole ukuthi amangqamuzana omdlavuza we-pancreatic athembele kakhulu kuphrotheni ukuze akhule futhi asakazeke. Imiphumela yocwaningo ingaletha amasu amasha okwelapha kanye nokuvimbela umdlavuza we-pancreatic.

I-American Cancer Society ilinganisela ukuthi iziguli ezingafika kuma-61% ezinomdlavuza wepancreatic osezingeni lokuqala zingaphila okungenani iminyaka emihlanu ngemuva kokuxilongwa. Kepha ezinye izinhlobo zomdlavuza we-pancreatic zinolaka kakhulu. Isibonelo, lapho kutholakala ukuthi ine-pancreatic ductal adenocarcinoma, ngokuvamile isivele isesigabeni esithuthukisiwe futhi izinga layo lokusinda leminyaka emi-5 lingaphansi kuka-10%. Kodwa-ke, ucwaningo olusha seluhlonze ubuthakathaka obuyinhloko balo mdlavuza onolaka, okungukuthi amangqamuzana omdlavuza we-pancreatic awumlutha weprotheni ebalulekile. Kulolu cwaningo olusha, uDkt Christopher Vakoc, uprofesa eCold Spring Harbour Laboratory eNew York, nethimba lakhe bathole isakhi sofuzo esifaka amaprotheni ahlasela kakhulu umdlavuza wepancreatic. Ungumuntu osemuva kokusebenza kwakhe elabhorethri kaProfesa Vakoc. Umcwaningi uTimothy Somerville ungumbhali oholayo, kanti leli phepha lisanda kushicilelwa ephephabhukwini i-Cell Report.

USomerville uchaze ukuthi abantu abatholakala benomdlavuza we-pancreatic bangaphila isilinganiso seminyaka emi-2. Kodwa-ke, labo abane-pancreatic ductal adenocarcinoma basinda ngendlela engagculisi. Abaphenyi beqembu likaProfesa Vakoc bacabanga ukuthi iprotheni ethile ingadala lo mdlavuza ukuba ube nolaka kangaka. Abacwaningi baqhubeka nokufunda iphrotheni TP63 besebenzisa amasiko atholakala ezicutshini ezijwayelekile ze-pancreatic noma i-pancreatic ductal adenocarcinoma. Ukuhlaziywa kukhombisile ukuthi ubukhona be-TP63 kulesimila buvumela amangqamuzana omdlavuza ukuthi akhule, ande futhi afinyelele kwezinye izingxenye zomzimba. .

USomerville uchaze ukuthi okunye okukhuthazayo okutholakele ukuthi amangqamuzana omdlavuza athembele ku-P63 ukuthi aqhubeke nokukhula. Ngakho-ke, siphenya ukuvinjelwa komsebenzi we-P63 njengendlela yokwelapha yeziguli. “Ngakho-ke, ukuqonda ukuthi kungani isakhi sofuzo se-P63 sisebenza kwabanye abantu kuzoveza izindlela zokuvikela ezibalulekile ezingaba yinzuzo enkulu ekusindeni komdlavuza we-pancreatic ontekenteke.”

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