Ukwelashwa okuhlosiwe komdlavuza wesisu kuqondiswa ukuhlolwa kofuzo

Ukuhlolwa kofuzo lomdlavuza wesisu

Ngemva kweminyaka ecishe ibe yishumi yokuthuthuka, ukuhlolwa kofuzo lwesimila sekuyisidingo esisheshayo senani elikhulu leziguli ezinomdlavuza. Isiqondiso sombiko wokuhlola esinikezwe ukuhlolwa kofuzo lwesimila sihambisana kahle nomqondo wokuthuthuka womuthi onembayo, futhi singene kuzo zonke izici zokuxilonga nokwelashwa kweziguli zesimila. Ezigulini, zingakhetha izidakamizwa eziqondiwe ukuze zelashwe ngokuqondile, zigweme ukuchezuka, futhi zigweme imiphumela emibi engadingekile. okubabayo.

Isimo samanje sokwelashwa okuhlosiwe komdlavuza wesisu

In most cases, surgery is still the main treatment for gastric cancer. However, the heterogeneity of gastric cancer is very strong, and its biological behavior is affected by the huge gene regulation in the cell. Therefore, only by classifying the essential characteristics of gastric cancer from the molecular level can early diagnosis and prognosis judgment of the isisu be more reasonable and accurate , Application of molecular targeted drugs for individualized and precise treatment of patients.

Njengamanje, izidakamizwa eziqondiwe ezilandelayo zivunyelwe:

Ngaphezu kwalokho, kunezinye izidakamizwa eziningi ezihlosiwe ezihlobene nomdlavuza wesisu ekuhlolweni komtholampilo, njengezidakamizwa ezivimbela i-HER2: i-lapatinib (Tykerb ®), i-pertuzumab (Perjeta ®) ne-trastuzumab emtansine (Kadcyla ®). Izidakamizwa ezivimba i-EGFR: I-Panitumumab (Victibi®) isidakamizwa esiqondise ku-EGFR ehlolelwa umdlavuza wesisu.

I-Global Oncologist Network ikhumbuza wonke umuntu ukuthi ukuhlolwa kofuzo kuyadingeka ngaphambi kokwelashwa okuhlosiwe. Kuphela ngokuqonda uhlobo lokuguqulwa kofuzo lwesimila lapho uhlelo lokwelapha oluphusile lungasungulwa ukuze kuzuze iziguli. Ngaphezu kwalokho, ekukhethweni kobuchwepheshe bokuhlola izakhi zofuzo, kuyadingeka ukukhetha ubuchwepheshe bokuhlola obufanele ngokuvumelana nenhloso yayo ehambisanayo . Kuphela ngokukhetha imikhiqizo egunyazwe i-State Food and Drug Administration lapho kungaqinisekiswa khona ukunemba nokuthembeka kwemiphumela yokuhlolwa.

Iziguli ezinomdlavuza wesisu zikhetha kanjani ukuhlolwa kofuzo?

I-Global Oncologist Network ikhumbuza iziguli ukuthi ukuhlolwa kofuzo lomdlavuza kanye nokuhlaziywa kokwelashwa komtholampilo kuyiphrojekthi ehlelekile edinga ukusekelwa okuqinile kwelabhorethri, ukulawulwa kwekhwalithi ephezulu yokuhlola kanye nethimba eliphezulu lokuhlaziya idatha. Ukuhlaziywa kokuhlolwa kofuzo okuhle kungagwema ukulahleka kwamathuba okwelashwa futhi kusindise izimpilo zeziguli ezinomdlavuza. Njengamanje, kunenqwaba yezikhungo zokuhlola izakhi zofuzo emakethe, futhi iziguli kufanele zikhethe ngokucophelela izinkampani zokuhlola izakhi zofuzo ukuze ziqinisekise ukunemba kwemiphumela yokuhlolwa.

Nabu ubuchwepheshe bokuhlola izakhi zofuzo obugunyazwe yi-FDA!

I-FoundationOne®CDx 

I-FoundationOne®CDx yagunyazwa yi-FDA njengomkhiqizo wokuqala wokuxilonga wohlobo lwe-pan-tumor . As a research tool, it assisted the discovery of countless scientific research results, and accumulated a large amount of data during this period. The current test coverage includes 324 genes and two molecular markers (MSI / TMB) that can predict the efficacy of immune checkpoint inhibitors. It can cover all solid tumors (except i-sarcoma) and can directly correspond to 17 izindlela zokwelapha ezihlosiwe ezigunyazwe yi-FDA!

Ekuhlolweni komtholampilo kwezakhi zofuzo zomdlavuza, amasu asetshenziswa kakhulu ahlanganisa ukulandelana kwe-Sanger, mass spectrometry genotyping, fluorescence in situ hybridization (FISH) kanye nokuhlaziywa kwe-immunohistochemical (IHC). “Ukutholwa komaka okukodwa okujwayelekile” okufana ne-FISH, i-IHC kanye nokutholwa kwe-hotspot yezakhi zofuzo eziningi (iphaneli ye-hotspot) kungathola kuphela uhlobo olulodwa noma ezimbili zokungajwayelekile okubalulekile kofuzo okubalulekile (njengokushintshwa okuyisisekelo kuphela). Ucwaningo luye lwabonisa ukuthi ubuchwepheshe bakamuva obuphelele bokulandelana kwesizukulwane esilandelayo bokuhlolwa kofuzo okuphelele komdlavuza bungahlonza zonke izinhlobo ezine zokungajwayelekile kwezakhi zofuzo (ukushintshanisa okuyisisekelo; ukufakwa nokususwa; ukuhluka kwenombolo yokukopisha nokuhlelwa kabusha), futhi inembe kakhulu kunokuhlola okuvamile, okujwayelekile.

Iziguli ezinomdlavuza zingahlolwa kanjani i-FoundationOne® CDx?

E-China, isevisi yokuhlaziya ehlinzekwa yi-Dean Diagnostics. I-Global Oncologist Network ingasiza iziguli ezinomdlavuza ukuthi zithole le sevisi, noma ukuhlolwa kofuzo ukuze uthole isitifiketi esigunyaziwe sasekhaya. I-Global Oncologist Network, njengenkundla eyaziwayo yeziguli ezinomdlavuza wasekhaya, bekuyisikhungo se-oncology kanye nochwepheshe bomdlavuza abaziwayo basebenzisana eduze ukuze njalo bahlele imihlangano emikhulu yokushintshisana kadokotela neziguli kanye nezinkulumo zesayensi ezithandwayo ukusiza iziguli zithole izinga elijwayelekile. kanye nezinhlelo zokuxilongwa nokwelashwa okugunyaziwe ngokubonisana nochwepheshe ekhaya naphesheya, futhi kuthuthukiswe izinga lokwelapha. Sizokwenza futhi imizamo eqhubekayo yokwethula ngokuqhubekayo ulwazi oluphambili lokulwa nomdlavuza emhlabeni, ubuchwepheshe, ochwepheshe, izidakamizwa, izivivinyo zomtholampilo, njll., futhi senze yonke imizamo yokuhlinzeka iziguli ezengeziwe ngezinsizakalo ezingcono zokulwa nomdlavuza.

ICancerFax njengendlela eyaziwayo yokuxilongwa komdlavuza wasekhaya kanye nokubonisana nokwelashwa kanye nesiteji senkonzo, izibophezele ekuhlinzekeni izinsiza zokulwa nomdlavuza ezisezingeni lokuqala ezigulini ezinomdlavuza wasekhaya, okuhlanganisa ubuchwepheshe bamuva bokulwa nomdlavuza kanye nezinsiza eziphezulu zochwepheshe bomdlavuza, ukumisa isimila esikhulu kunazo zonke. isikhungo sokubonisana nesokubonisana e-India, futhi Usebenzisane nezikhungo zokubonisana zesimila ezidumile kanye nochwepheshe e-United States, China, Israel, naseYurophu ukuze ube uchwepheshe othembeke kakhulu wokuxilongwa nokwelashwa kwesimila emhlabeni.