Ucwaningo olusha oluvela eNyuvesi yaseMcMaster eCanada luthi bathole isu elisha lokwelapha i-acute myeloid leukemia. Ngokugqugquzela ukukhiqizwa kwamangqamuzana amafutha emnkantsheni wethambo kanye nokulungisa i-microenvironment yomnkantsha, ingavimbela amangqamuzana egazi leukemia futhi ikhuthaze ukukhiqizwa kwamangqamuzana egazi avamile. Lo mehluko uthi Isu lokwelapha elingaqondile lokwelashwa okujwayelekile kwamanje libonakala linezinzuzo, hhayi kuphela ngaphandle kodwa nangaphakathi. (Nat Cell Biol. 2017; 19: 1336-1347. IDoyi: 10.1038 / ncb3625.)
I-acute myeloid leukemia (AML) ibonakala ngesizukulwane samangqamuzana wegazi egazini. Iziguli zihlushwa ukutheleleka okunzima kanye ne-anemia ngenxa yokukhiqizwa okunganele kwamangqamuzana egazi abomvu ajwayelekile. Ukwelashwa okujwayelekile kugxile ekubulaleni amangqamuzana e-leukemia ngamandla omlilo, kungakunaki ukukhiqizwa kwamangqamuzana egazi abomvu anempilo.
Ngokuya ngokubheka kweziguli ze-leukemia, abacwaningi baqoqa inani elikhulu lamasampula omnkantsha ezigulini ze-leukemia ukuze benze ucwaningo, uma kuqhathaniswa futhi kuthathwa isithombe ngamaseli aphilile emnkantsheni wethambo namaseli we-leukemia, bathola lo mphumela wamaseli anonile. Ngokusebenzisa amasiko we-in vitro cell kanye nokuhlola imodeli yesimila sokucwaninga, abacwaningi bathole ukuthi amangqamuzana abukhali we-myeloid leukemia abhubhise ngokukhethekile imvelo engaphansi kwamangqamuzana anamafutha emnkantsheni, okuholele ekulawulweni okungalingani kwamaseli we-hematopoietic stem kanye nama-progenitor cell kanye nokunqanda ukukhiqizwa kwegazi elijwayelekile amaseli emnkantsheni wethambo.
Ucwaningo luveze okokuqala lobu budlelwano phakathi kokukhiqizwa kwama-adipocyte emnkantsheni kanye nama-erythrocyte emnkantsha ojwayelekile. Lo mphumela awubangelwa kuphela i-hematopoietic microenvelo yomnkantsha wamathambo, okungukuthi, i-niche igcwele, kepha futhi nendima yama-adipocyte enqubeni yokwehlukanisa. Umphumela okhawulelayo wamaseli wegazi. Lokhu kutholakala kunikeza imibono emisha yokwelashwa kwe-myeloid leukemia futhi kulindeleke ukuthi kuthuthukise izimpawu zokwehluleka kweziguli ezine-myeloid leukemia.
Isekelwa umuthi okhuthaza ukukhiqizwa kwamangqamuzana anamafutha, amangqamuzana anonile emnkantsheni wethambo aphume ngempumelelo amaseli we-leukemia, enza indawo yokukhiqizwa kwamangqamuzana egazi okunempilo nokususa ingosi. Ukuhlolwa kwe-in vitro, i-PPARγ inhibitors kungadala ukukhiqizwa kwama-adipocyte omnkantsha. Ngokushintsha indawo emnkantsha amathambo, inikeza amandla ekukhiqizeni amangqamuzana egazi enempilo futhi ngasikhathi sinye ivimbela ukwakheka kwamaseli we-leukemia, angahlinzeka ngendlela entsha yokwelashwa okungaqondile kwe-acute myeloid leukemia. Leli su lokwelashwa okungaqondile kufanele lithembise kakhulu kunezokwelapha ezijwayelekile, ezingazange zenze inqubekela phambili enkulu emashumini ambalwa edlule.
Abacwaningi baveze ukuthi okugxilwe kukho kokwelashwa okujwayelekile okukhona wukubulala amaseli esimila, ukuguqula indlela yokucabanga, nokusebenzisa amasu ahlukene okushintsha indawo yokusinda yamangqamuzana omdlavuza ukuze kuzuzwe imiphumela yokwelapha. Ngenkathi icindezela amangqamuzana omdlavuza, iqinisa amaseli aphilile ukuze akwazi ukuvuselelwa endaweni entsha ebangelwe yizidakamizwa.
