Ukufakelwa kwe-stem cell kuyindlela yokwelapha esebenzayo ye-myeloma eminingi, uhlobo lomdlavuza wegazi. Le nqubo ibonise imiphumela ethembisayo ekwenzeni ngcono izimpilo zalabo abane-myeloma eminingi, enikeza ithuba elisha lokuphulukiswa. Hlanganyela nathi ohambweni lwamathuba kanye noshintsho oluhle ekunakekelweni kwe-myeloma - kufanele kufundwe kunoma ngubani ofuna umbono omusha ngokwelashwa komdlavuza!
I-myeloma eminingi uhlobo lomdlavuza oluthinta amangqamuzana e-plasma, ayingxenye ebalulekile yamasosha omzimba atholakala emnkantsheni wamathambo. Lapho la mangqamuzana e-plasma eba nomdlavuza, angaphindaphindeka ngokungalawuleki, akhiphe amangqamuzana egazi anempilo.
Lokhu kungaholela ekwenzeni amathambo abe buthaka, i-anemia, izinkinga zezinso, kanye nokuncipha kwamasosha omzimba.
Ukwelashwa okusebenzayo kubalulekile ukuze uwine lo mdlalo wokusinda oyinselele. Yibo abaletha ithemba, babuyisele impilo, futhi benze ukulwa ne-myeloma eminingi kungabi nzima kakhulu.
Uma kuziwa ekwelapheni i-myeloma eminingi, enye yezindlela ezinhle kakhulu ukwelashwa kwe-myeloma eminingi eNdiya i-stem cell transplant. Kule bhulogi, sizoxoxa nge-Stem Cell Ukufakelwa kwe-Myeloma eminingi kanye nomthelela wawo oguqulayo kubantu abalwa nalo mdlavuza wegazi.
Hlanganyela nathi kulolu hambo olukhanyayo njengoba sihlola amajika ahlonyiswe ngolwazi, ithemba, kanye nomfutho wokwenza umehluko ezimpilweni zeziguli ezinomdlavuza.
Yiziphi Ezinye Izindlela Zokwelashwa Eziningi Ze-Myeloma Ezitholakala ENdiya?
Ngaphandle kokufakelwa kwe-stem cell, udokotela wakho angaphinde akucele ukuthi ulashwe okulandelayo, kuye ngesimo sakho:
I-Chemotherapy:
I-Chemotherapy ye-myeloma eminingi ihilela ukusetshenziswa kwezidakamizwa ezinamandla ezikhomba futhi zivimbele ukukhula okusheshayo kwamangqamuzana omdlavuza, okuthinta ikhono lawo lokuhlukanisa nokusabalala.
I-Immunotherapy:
Ukwelashwa kwe-CAR T cell therapy eNdiya iwuhlelo olusha lwe-immunotherapy oluphatha zonke izinhlobo zomdlavuza wegazi. Le ndlela eqondene nawe ihlanganisa ukuguqula ama-T cell esiguli ukuze aqondise futhi abhubhise amaseli omdlavuza.
Ngaphezu kwalokho, i izindleko zokwelashwa kwe-t cell eNdiya iyathengeka kakhulu uma iqhathaniswa namanye amazwe.
Ukwelashwa Kwemisebe:
Ukwelashwa ngemisebe kusebenzisa imithamo ephezulu yemisebe egxilile ukucekela phansi noma ukulimaza amaseli e-myeloma ezindaweni ezithile. Nakuba isebenza kahle ekudambiseni izimpawu nasekunciphiseni isisu ubukhulu, ukusetshenziswa kwayo kuvame ukukhawulelwa ezimweni ezithile ngenxa yokuthi kungenzeka kube nemiphumela emibi.
Iyiphi Indima Edlalwa Amaseli Esiqu Emzimbeni Wethu?
Ama-stem cells awuhlobo olukhethekile kakhulu lwamangqamuzana enziwe ekuqaleni komnkantsha wethu. Lawa ma-stem cells ayavuthwa futhi akhe amangqamuzana egazi abomvu, amangqamuzana egazi amhlophe, nama-platelet. Ama-stem cells abalulekile ekukhuleni, ekulungiseni izicubu, nasekugcineni impilo yonke.
Ezigabeni zokuqala zokuphila, ama-embryonic stem cells angaguqukela kunoma yiluphi uhlobo lweseli, abeke isisekelo sesakhiwo esiyinkimbinkimbi somzimba.
Kukho konke ukuphila, ama-stem cells amadala ahlala ezicutshini ezihlukahlukene, alungele ukuvala amangqamuzana alimele noma agugile, okunikela ekuvuseleleni okuqhubekayo nokuvuselelwa komzimba. Leli khono eliyingqayizivele lama-stem cell linesithembiso esikhulu sokwelapha izifo eziyinkimbinkimbi ezifana umdlavuza wegazi.
Kuyini Ukufakelwa Kwe-Stem Cell Nge-Myeloma Eningi?
Ukufakelwa kwe-stem cell kuyindlela yokwelapha esebenzayo kubantu abaphethwe yi-myeloma eminingi. Lokhu kwelashwa kubandakanya ukubuyisela amangqamuzana egazi ayingozi esikhundleni sawo anempilo ukuze kukhuliswe amathuba okunqoba lesi sifo.
Nakuba ukufakelwa kwe-stem cell kungelona ikhambi, ucwaningo lubonisa ukuthi kuthuthukisa amazinga okusinda uma kuqhathaniswa nokwelashwa ngamakhemikhali kuphela.
Ekulweni ne-myeloma eminingi, ukwelashwa komdlavuza wezinga eliphezulu kuvame ukudingeka. Nokho, ukwelashwa okunamandla kungalimaza umnkantsha, izicubu ezinamathambo ezinamathambo akhiqiza amangqamuzana egazi.
Ukufakelwa kuqalisa kabusha umnkantsha ngokuphumelelayo, ukuwuvumela ukuthi ukhiqize amaseli egazi anempilo futhi. Nakuba ukwelapha nge-stem cell kwe-myeloma eminingi e-India kuye kwabonakala kuwusizo kubantu abaningi, kubalulekile ukuqaphela ukuthi kungase kungafaneleki kuwo wonke umuntu.
Ngakho-ke, kungcono ukubonana nodokotela wakho futhi ufunde mayelana nezinketho onazo ngaphambi kokuqala inqubo yokufakelwa kwe-stem cell.
Izigaba ze-Multiple Myeloma Disease
Lesi sifo siqhubeka ngezigaba ezahlukahlukene, futhi lezi zigaba zihlukaniswa kusetshenziswa i-International Staging System (ISS) noma i-Revised International Staging System (R-ISS). Lapho inombolo yesiteji iphakeme, i-myeloma iyanda emzimbeni.
Multiple Myeloma 1st isigaba
Uma lesi sifo siseSigabeni I, izinga le-serum beta-2 microglobulin liphansi (ngaphansi kuka-3.5 mg/L), izinga le-albumin lingaphezulu (3.5 g/dL noma ngaphezulu), futhi akukho okungavamile okuyingozi kakhulu kwe-cytogenetic.
Multiple Myeloma 2nd isigaba
Amacala aseSigabeni II awafani nezimfuneko zeSigaba I noma Isigaba III. Kuyisigaba sezinguquko esinezici ezihlukahlukene zomtholampilo kanye nokubikezelwa.
Multiple Myeloma 3rd isigaba
Isigaba III simakwe ngesifo esithuthuke kakhulu, esinamazinga aphezulu e-serum beta-2 microglobulin, amazinga aphansi e-albumin, kanye nokuba khona kwe-cytogenetics engcuphe kakhulu.
Yiziphi Izinhlobo Zokufakelwa Kwe-Stem Cell?
Ngokusekelwe emthonjeni wama-stem cells, kunezinhlobo ezinhlanu eziyisisekelo zokwelapha i-stem cell, futhi uhlobo ngalunye lungahlukaniswa ngokuqhubekayo ngokusekelwe kumnikeli. Okulandelayo yizinhlobo eziyinhloko:
Ukufakelwa kwe-Autologous Stem Cell
Ku-autologous stem cell transplant ye-myeloma eminingi, isiguli sisebenza njengomnikezeli we-stem cell waso. Cishe uhhafu wabantu ababhekene ne-myeloma eminingi bangaya kulolu hlobo lokufakelwa, futhi kubhekwa njengendlela engcono kakhulu yokulwa nalesi sifo.
Ukufakelwa kwe-Allogeneic Stem Cell
Ekufakweni kwe-allogeneic, ama-stem cells atholakala kumnikeli, okungenzeka abe yilungu lomndeni eliseduze noma umnikeli ongahlobene. Umfowenu noma udadewenu uvamise ukukufanelekela kangcono, kodwa uma bengatholakali, kunethuba lokuthola umnikeli ongahlobene ofana kahle.
I-drawback ukuthi lokhu kufakelwa kwe-stem cell ye-myeloma eminingi kuyingozi kakhulu kunokusebenzisa amaseli akho. Kodwa-ke, angaba namandla amakhulu ekulweni nomdlavuza ngoba amangqamuzana omnikeli angahlasela noma yimaphi amaseli e-myeloma angenangqondo asinda ekwelashweni kwangaphambili.
I-Syngeneic Stem Cell Transplant
Lolu uhlobo lokufakelwa kwe-allogeneic lapho onikelayo nomamukeli bengamawele afanayo. Uma unenhlanhla yokuba newele elifanayo, leli kungaba ithikithi lakho legolide.
Ngenxa yokuthi wena newele lakho ninezakhi zofuzo ezifanayo, amangqamuzana atshalwe kabusha afaneleka kangcono kakhulu. Le nqubo yokufakelwa kwe-stem cell iyinzuzo ephawulekayo ekulweni ne-myeloma eminingi, okwenza uhambo lokwelapha lushelele futhi luphumelele.
I-Tandem Stem Cell Transplant
Le nqubo yokufakelwa kwe-stem cell ye-myeloma eminingi iqukethe ukufakelwa kwe-autologous okunamandla okubili: okokuqala, uthola umzuliswano oqinile wokwelashwa komdlavuza; ke, ukukhuthaza ukuphulukiswa, ama-stem cells akho anempilo ayafakwa.
Ngemva kwezinyanga ezimbalwa, uphinda yonke inqubo ngomzuliswano owengeziwe wokwelapha kanye nokufakelwa okwengeziwe kwe-autologous.
Ucwaningo luphakamisa ukuthi, kwabanye abantu, le nqubo yokufakelwa kwe-stem cell ingase isebenze kangcono kunokufakelwa okukodwa nje. Nokho, kungase kube nemiphumela engemihle eyengeziwe uma kuqhathaniswa nokufakelwa okukodwa kwe-autologous.
Ukufakelwa Kweseli Yesiqu Esincane
Ukufakelwa kwe-stem cell encane kufana nendlela elula yokulwa ne-myeloma eminingi, ikakhulukazi uma umdala kancane noma ubhekene nezinye izinkinga zezempilo.
Lolu hlobo lwenqubo yokufakelwa kwe-stem cell ye-myeloma eminingi i-allogeneic, okusho ukuthi uthola amaseli abanikeli, kodwa incike kakhulu kulawa maseli anikelayo ukuze abhubhise amaseli omdlavuza.
Inzuzo enkulu ukuthi uzothola imithamo ephansi yokuqala ye-chemo nemisebe, okwenza yonke inqubo ibe mnene.
Yazi Inqubo Yokufakelwa Kwe-Stem Cell Ye-Myeloma Eningi
Inqubo ye-stem cell ye-myeloma eminingi iwuchungechunge oluhlelwe kahle lwezinyathelo eziklanyelwe ukufaka amangqamuzana alimele noma anomdlavuza esikhundleni samaseli anempilo.
Isigaba Sokulungiselela:
Ithimba lakho lezokwelapha lihlola impilo yakho iyonke, isigaba sesifo, kanye nokutholakala komnikeli ofanelekayo (uma i-allogeneic).
Ngokuya ngohlobo lokufakelwa, ungathola i-chemotherapy yomthamo omkhulu, imisebe, noma inhlanganisela yokuqeda amangqamuzana omdlavuza futhi wenze indawo yamaseli anikelwe.
Ukuqoqwa kwamaseli e-Stem:
Ngaphambilini, lawa maseli ayekhishwa ngokuqondile emnkantsheni ngendlela eyaziwa ngokuthi isivuno somongo, okuzwakala kushubile. Kodwa qagelani? Namuhla, kulula kakhulu.
Isikhathi esiningi, lawa mangqamuzana amaqhawe aqoqwa egazini. Kungakhathaliseki ukuthi ungumnikeli noma omunye umuntu, uzonikezwa umuthi othile ukuze ugqugquzele ukukhula kwala maseli futhi uwakhuthaze ukuba ashiye umnkantsha.
Igazi libe selidluliswa ngeshubhu elisemthanjeni omkhulu liye emshinini oqoqa ama-stem cell bese ubuyisela igazi elisele emzimbeni wakho.
Lawa maseli aqoqiwe aba yiqhwa aze adingeka, alinde ngesineke ithuba lawo lokujoyina impi yokulwa ne-myeloma eminingi lapho usuwalungele.
Ukutshala:
Ngemva kokwelashwa kwe-conditioning, ama-stem cells aqoqiwe (okungaba awakho noma avela kumnikezeli) afakwa egazini lakho, okufana nokumpontshelwa igazi. Ama-stem cells aqoqiwe azongena emnkantsheni wakho enze amaseli egazi amasha.
Isigaba Sokubuyisela
Isikhathi sokubuyiselwa kwe-stem cell ngemva kokufakelwa sifana nohambo olubuyela empilweni ephelele ngemva kwempi enzima. Uma ufakwe i-allogeneic transplant, odokotela baqapha ukuthi amaseli akho amasha ahlangana kanjani nomzimba wakho.
Isifo se-Graft-versus-host senzeka lapho amangqamuzana anikelayo eqala ukulwa nomzimba wakho. Kodwa ungethuki, odokotela bayakwazi ukuyelapha. Manje, kuthatha isikhathi esingakanani ukululama?
Kuzothatha amaviki angu-2-6 ukuze izibalo zakho zegazi zibuyele kwesijwayelekile. Ngemva kwamasonto ambalwa, lapho izibalo zakho seziphakeme ngokwanele ukulwa nezifo futhi uvimbele ukopha, ungase uvunyelwe ukuya ekhaya.
Nokho, inqubo yokutakula ayiqedi lapho; kungathatha izinyanga eziyisithupha noma ngaphezulu ukululama ngokugcwele. Ngisho noma usekhaya, odokotela bakho bazokubheka ngokucophelela ukuze baqinisekise ukuthi konke kuhamba ngendlela.
Yazi Imiphumela Eseceleni Yokufakelwa I-Stem Cell
Nakuba ukufakelwa kwe-stem cell kuwukuhlinzwa okunamandla futhi okungase kusindise ukuphila, kungaba nenani lemiphumela engemihle enjengalena:
Ukukhathala
Uhudo noma ukuqotshwa
Ukubalwa kwamaseli egazi aphansi
Umlomo obuhlungu
Ukulahlekelwa kwesifiso
Ukwehla kwesisindo
Ukulahlekelwa izinwele
Ukugxila okwehlisiwe
Iyini Impilo Elindelekile Ngemva Kokufakelwa Kwe-Stem Cell Ye-Myeloma Eningi?
Ngemuva kokufakelwa kwe-stem cell iminyaka eminingi yokuphila kwe-myeloma iyathembisa. Uma udlula eminyakeni emi-2 kuya kwemi-5 yokuqala ngemva kokufakelwa, amathuba okuphila eminye iminyaka eyi-10 akhuphukela cishe kumaphesenti angu-80.
Lokhu kusho ukuthi uma uphatha kahle izimpawu zakho, ugcine amasosha akho omzimba esesimweni esihle, futhi uzinakekela, maningi amathuba okuba nempilo ende nenempilo.
Zithini Izindleko Zokufakelwa I-Stem Cell Ye-Myeloma Eningi ENdiya?
Izindleko zenqubo yokwelashwa kwe-stem cell e-India ziphakathi kwama-Rs. 8 Lakhs kuya kuRs. 40 Lakhs.
ICancerFax Ingakusiza Kanjani?
Ekusongeni indima yokufakelwa kwe-stem cell ekwelapheni i-myeloma eminingi, kufana nokuba nesikhali esinamandla ekulweni nalesi sifo esiyinselele.
Inqubo inzima, inokwehla nokwenyuka, kodwa ukuyiqeda ngokuvamile kusho ithuba elingcono lokuphila ende, impilo enempilo. Singakusiza uthole izibhedlela ezihamba phambili futhi uhlangane nochwepheshe abalungile e-India.
Besilokhu sinikeza ukunakekelwa kwesiguli okukhethekile kusukela ngo-2019 ngezindleko ezingabizi. Thintana namathuba andayo enhlalakahle kanye nempilo.
