Scientists at the University of California, San Francisco have discovered a common genetic driver of aggressive meningioma, which can help clinicians detect this dangerous cancer earlier and find new treatments for these difficult-to-treat tumors. A research team led by Dr. David Raleigh found that increased gene activity called FOXM1 seems to be responsible for the aggressive growth, and these tumors frequently relapse.
Ukuphenya izinto ezingadala i-meningioma enolaka, ithimba likaRaleigh laqoqa amasampula angama-280 womuntu we-meningioma kusuka ngo-1990 kuya ku-2015. Kusetshenziswa izindlela ezahlukahlukene, kufaka phakathi ukulandelana kwe-RNA nokuveza imininingwane yezakhi zofuzo, abaphenyi bafune izixhumanisi phakathi kokusebenza kofuzo nokukhiqizwa kwamaprotheni ku lezi zicubu kanye nemiphumela yomtholampilo yeziguli. Ekugcineni, kwatholakala isakhi sofuzo esibizwa nge-FOXM1 njengesisekelo sokukhula kwe-meningioma engenayo, futhi futhi siyinkomba yemiphumela elandelayo yomtholampilo, kubandakanya nokufa.
Abaphenyi baphinde bathola ukuxhumana okusha phakathi kokwanda kwama-meningiomas anolaka kanye nokusebenza kwezindlela zokukhombisa amaseli ahlukahlukene, okuthiwa yi-Wnt, okuvame ukudlala indima ekukhuleni kombungu nasekwakhekeni kwezicubu. Njengoba kunikezwe ukuthi iphrotheni ekhiqizwa yi-FOXM1 ingadlulisa amasiginali eceleni kwendlela ye-Wnt, idatha entsha ikhombisa ukuthi umsebenzi wokubambisana we-FOXM1 kanye ne-Wnt pathway kungaholela ekwandeni okulandelayo kwama-meningiomas. I-Hypermethylation ingaba yimbangela yokuqala yokwakheka kwama-meningiomas anolaka.
URaleigh uthe umsebenzi wesikhathi esizayo udinga ukuthola ukuthi iziphi izakhi zofuzo ezisebenza ku-FOXM1 ukushayela ukukhula kwe-meningioma, nokuvimba lezi zinhloso ngemithi yokwelashwa. Kuyathenjwa ukuthi kuzoba nemithi yokuvimba i-pathogenesis yamathumba obuchopho kule ndlela ngokushesha futhi kusizakale iningi leziguli ezinomdlavuza.
