Izimpawu ezithile zamangqamuzana ezikhishwe amaseli omdlavuza we-pancreatic sezinqunyiwe. Umdlavuza we-pancreatic uvame ukutholakala ngemva kokusabalala kwalesi sifo, futhi ukwelashwa ngamakhemikhali ngokuvamile akunawo umthelela ekubambezeleni ukukhula komdlavuza. Ngisho nokwelashwa, iziguli eziningi zingaphila cishe izinyanga eziyisithupha kuphela ngemva kokutholakala ukuthi zinomdlavuza we-pancreatic.
Emdlavuzeni we-pancreatic, ama-fibroblasts maningi, abalwa cishe ngama-90% wesisindo somzimba. Le matrix ivimbela izidakamizwa ze-anticancer ukuthi zingangeni kulitshe. Ngaphezu kwalokho, amaseli e-stromal akhipha izinto ezinomthelela ekukhuleni kwesimila. Abaphenyi baselebhu kaProfesa David Tuveson eCold Spring Harbour Laboratory (CSHL) bakholelwa ukuthi izinhlobo ezahlukahlukene zokwelashwa zingangcono. Ingxenye yenkinga ukuthi amangqamuzana omdlavuza kumanyikwe avikelwe yi-matrix eminyene ebazungezile. I-stroma iyinhlanganisela yezingxenye ezingaphandle kwamaseli namaseli angenawo umdlavuza abizwa nge-stroma. Zonke izicubu eziqinile zine-stroma. Ukunqoba imiphumela yokuvikela ye-matrix kuyinselele, kepha njengoba kubikiwe kuphephabhuku i-Cancer Discovery ngo-Okthoba 26, 2018, umkhondo omusha ovela eqenjini le-Tuveson ukhomba isu elithembisayo. Okutholakele okusha kukhombisa ukuthi imishanguzo ekhomba indlela elungile yamaselula ayivimbeli kuphela amaseli asekela isimila ku-matrix, angahle aqashwe empini yokulwa nomdlavuza.
Ukhiye we-matrix ama-fibroblasts, angakhiqiza izicubu ezihlangene ze-matrix, futhi angakhiqiza nezinto ezikhuthaza ukukhula kwamangqamuzana omdlavuza futhi zivimbele amasosha omzimba ekuhlaseleni amangqamuzana omdlavuza. Ngonyaka odlule, ithimba likaTuveson lathola ukuthi i-pancreatic tumor stroma iqukethe okungenani izinhlobo ezimbili ze-fibroblasts. Uhlobo olulodwa lubonisa izici ezaziwa ukuxhasa ukukhula kwesimila, kanti olunye uhlobo lukhombisa imiphumela ehlukile. Izindaba ezinhle ukuthi ubunikazi bama-fibroblast abulungisiwe, futhi ama-fibroblast akhuthaza isimila angaba yizici ezikhawulela isimila. UGiulia Biffi, umcwaningi osasebenza ngemuva kokwenza umsebenzi elabhoratri laseTuvson, uchaze wathi, “Lawa maseli angaguquka abe amanye, kuya ngemikhondo ayithola kumakhemikhali amancane kanye nomdlavuza. Ngokomqondo, ungaguqula amaseli akhuthaza isimila abe ngamancindezeli we-tumor, Akugcini nje ngokuqeda amaseli akhuthaza isimila. ”Bathole ukuthi i-IL-1 ishayela ama-fibroblast anezakhiwo ezikhuthaza isimila. Baphinde bathola ukuthi enye i-molecule, i-TGF-β, isimboza kanjani lesi siginali futhi igcina ama-fibroblast esimweni esingahle silwe nomdlavuza. UBiffi uthe iziguli zingazuza kakhulu enhlanganisweni yezindlela zokwelapha ezibhekise kumaseli omdlavuza nasengxenyeni yemvelo esekela ukukhula kwazo.
https://www.medindia.net/news/pancreatic-cancer-fresh-insights-183360-1.htm
