Uma ufunda lokhu, wena noma mhlawumbe omunye wabathandekayo bakho usohambweni okungekho muntu ohlela ukuluthatha—indlela yokubhekana nomdlavuza.
Siyaqonda ukuthi lo mgwaqo ugcwele ukungaqiniseki, ukwesaba, kanye nezikhathi lapho kuzwakala sengathi umhlaba ubheke phezulu. Kodwa kunezindaba ezinhle kuwe, ezingase ziqede ukukhathazeka kwakho!
Ake sikhulume ngokuthile okungaletha umsebe wethemba ohambweni lwakho - i-immunotherapy.
Kungaphezu nje komuthi; kuwumsebe wethemba kanye nesikhumbuzo esiqhubekayo sokuthi awuwedwa, isayensi ilwa nawe.
Kule bhulogi, sizoxoxa ngendima ebalulekile ye immunotherapy ekwelashweni kwe-lymphoma, okunikeza iziguli ezinomdlavuza ithemba elisha.
Sizokukhombisa ukuthi kanjani ukwelashwa kwe-t cell therapy eNdiya ihlakaniphe kakhulu futhi iphumelela kakhulu kunezinye izinqubo zezokwelapha. Ngakho-ke, hlala uzungeze, futhi ake sithole izinzuzo ezimangalisayo ze-immunotherapy i-lymphoma ndawonye!
Iyini I-Lymphoma?
I-Lymphoma iwuhlobo lomdlavuza oluqala ohlelweni lwethu lwe-lymphatic, oluyingxenye ebalulekile yamasosha ethu omzimba.
Iwuhlobo lwengqamuzana elimhlophe legazi elakheka emnkantsheni. Lawa ma-lymphocyte ajikeleza yonke imizimba yethu ngegazi nezinhlelo ze-lymphatic.
Uhlelo lwe-lymphatic, oluqukethe izakhi ezibalulekile njengama-lymph nodes, lusebenza njengesivikelo ngokuhlunga uketshezi lwe-lymph ukuze lukhiphe izinhlayiya zangaphandle.
Izinhlobo ezihlukahlukene zama-lymphocyte, kuhlanganise nama-B cell, T cell, namaseli abulalayo wemvelo (NK), akhula ngaphakathi kwama-lymph nodes ukuze ahlasele amagciwane nabahlaseli abakhona ku-lymph fluid.
Ama-lymphomas ayenzeka lapho ama-lymphocyte anempilo eshintsha abe amangqamuzana anomdlavuza. Lokhu kuhlukanisa i-lymphomas ibe izinhlobo ezintathu: i-B cell lymphomas (evame kakhulu), I-T cell lymphomas, kanye ne-NK cell lymphomas (engavamile kakhulu kodwa kungenzeka).
Noma ukubhekana ne-lymphoma kuwubuqili impela, izindlela zesimanje ezifana ne-car t immunotherapy ye-lymphoma zisinika ithemba futhi zinika amandla amasosha ethu omzimba ukuze alwe ngokuqinile naphezu kwezinselelo ezilethwayo.
Izinhlobo ze-Lymphoma
I-Lymphoma ihlasela kakhulu izingane kanye nabantu abadala futhi ihlukaniswe yaba izinhlobo ezimbili -
I-Hodgkin Lymphoma (HL)
Lolu hlobo lwe-lymphoma lubonakala ngokuba khona kwengqamuzana ethile engavamile ebizwa ngokuthi i-Reed-Sternberg cell.
IHodgkin lymphoma ngokuvamile iqala kuma-lymph nodes futhi ingasakazekela kwezinye izingxenye zomzimba. Akuvamile uma kuqhathaniswa i-non-Hodgkin lymphoma.
I-Non-Hodgkin Lymphoma (NHL)
Leli yiqembu elivame kakhulu futhi elihlukahlukene lama-lymphomas ahlanganisa ama-subtypes ahlukahlukene. I-Non-Hodgkin lymphomas ingavela ezinhlotsheni eziningana zama-lymphocyte futhi ingathinta ama-lymph nodes, i-spleen, i-bone marrow, nezinye izitho.
I-CAR T Ye-Lymphoma Ibhala Kanjani Imithetho Yokunakekelwa Komdlavuza?
I-India isanda kwethula indlela yayo enamandla nephumelelayo yokusiza abantu abaphethwe i-lymphoma. Lokhu kwelashwa okusha kwe-immunotherapy kwe-lymphoma kufana nokunikeza amasosha akho omzimba ukuthuthukiswa okunamandla.
I-CAR T imele ukuthi “Chimeric Antigen Receptor T-cell,” okungase kuzwakale kuyinkimbinkimbi, kodwa empeleni kuyindlela engcono kakhulu yokushaja amaseli ethu omzimba omzimba.
Odokotela bathatha amanye amangqamuzana ethu omzimba omzimba, bawaguqule elebhu ukuze babone futhi baqondise amaseli e-lymphoma, bese bewabuyisela emizimbeni yethu ukuze babone futhi baqede amangqamuzana omdlavuza.
Ngokocwaningo, ukwelashwa kwe-CAR T-cell kunezinga eliphezulu lempumelelo, namaphesenti amaningi eziguli asabela kahle.
Isibonelo, ku izivivinyo zokwelashwa ngezinhlobo ezithile ze-lymphomas, amazinga okuphendula adlule ku-80%, okubonisa ithonya elibalulekile kulesi sifo.
Lokhu kwelashwa kunenzuzo ikakhulukazi ezigulini ezingazange zisabele kahle ekwelashweni okujwayelekile. I izindleko zokwelashwa kwe-t cell eNdiya cishe $ 57,000.
Nokho, ezinsukwini ezizayo izinkampani ezifana ne-Immuneel ne-Cellogen zizokwethula ukwelashwa kwazo okusha kwe-CAR-T okuzosukela ku-$30,000 kuya ku-$40,000.
I-Immunotherapy Yomdlavuza We-Lymphoma Ihluke Kangakanani Emithi Yokwelapha Evamile?
Kulungile, ake siphule! Ukwelashwa kwe-immunotherapy kwe-Hodgkin's lymphoma kanye ne-Non-Hodgkin lymphoma kunamazinga empumelelo amakhulu uma kuqhathaniswa nokwelashwa okuvamile.
I-Chemotherapy-
Ukwelashwa okunamandla okusebenzisa i-intravenous noma izidakamizwa eziphuzwayo ukuze ziqondise futhi zibhubhise umdlavuza amaseli kuwo wonke umzimba.
Nakuba i-chemotherapy iphumelela ngokumelene ne-lymphoma, ingaba nethonya elibi kumaseli anempilo, okuholela emiphumeleni emibi kakhulu.
Ukwelashwa kwamafutha
Lokhu kwelashwa kuvame ukubhangqwa ne-chemotherapy futhi kusebenzisa amandla aphezulu X-ray ukukhomba ngokuqondile amaseli e-lymphoma aqoqene kuma-lymph nodes.
I-Stem Cell Transplants
Ukufakelwa kwe-stem cell, okuvame ukubizwa ngokuthi ukufakelwa komnkantsha, kungadingeka ngoba ukwelashwa ngamakhemikhali kanye nokwelashwa ngemisebe kungalimaza impilo. amangqamuzana egazi kanye nomdlavuza amaseli. Lokhu kwelashwa kuthatha indawo yamangqamuzana egazi anempilo ukuze asekele ukululama.
I-Photopheresis
Iwuhlobo lwe-photoimmunotherapy olusebenzisa ukukhanya ukuze kusebenze amasosha omzimba ekulweni nezinhlobo ezithile ze-lymphoma ezingabangelwa ukufakelwa kwe-stem cell.
I-Phototherapy
I-Phototherapy ibonakala iyindlela yokwelapha ethembisayo ye-T cell lymphoma ye-cutaneous yesigaba sokuqala. Isebenzisa ukukhanya kwe-ultraviolet (UV) ukukhomba nokubhubhisa amaseli omdlavuza wesikhumba.
Ukuhlinzwa
Nakuba ukuhlinzwa kuvame ukusetshenziselwa ukuxilonga i-lymphoma, kunezinye izimo lapho isisu ukuqedwa ngokuhlinzwa kokuhlinzwa kuthathwa njengokufanelekile.
Ukubhekisisa Imiphumela Eseceleni Ye-Immunotherapy
Funda ngemiphumela emibi ye-immunotherapy ekwelapheni i-lymphoma. Umthelela uyahlukahluka kumuntu nomuntu, kuya ngokuthi ingabe i-immunotherapy ye-Hodgkin's lymphoma, i-immunotherapy ye-follicular lymphoma, noma i-immunotherapy ye-b cell lymphoma enkulu. Kodwa-ke, eminye ye-immunotherapy ejwayelekile yemiphumela emibi ye-lymphoma yilena elandelayo:
Ukukhathala
Ukusabela Kwesikhumba
Izimpawu Ezifana Nomkhuhlane
I-Nausea ne-Vomiting
Uhudo noma Ukuqunjelwa
Ukulahlekelwa Ukudla
Izindwangu zegazi
Isiyezi Noma Ukudideka
Ukuphathwa yikhanda
Isibalo samangqamuzana egazi aphansi
Ukuqonda Izinhlobo Ze-Immunotherapy Treatment Option
Iqhaza Le-Immunotherapy Ku-Lymphoma Treatment ibaluleke kakhulu njengoba lezi zindlela ezintsha zilungisa kabusha ukwelashwa komdlavuza. Ake sithole ukuthi lezi zindlela zokwelapha ezikhethekile, kusukela kumasosha omzimba kuye emithini yokugoma, ziwushintsha kanjani umdlalo ekulweni nomdlavuza.
Ama-Antibodies e-Monoclonal
Amasosha omzimba e-Monoclonal ama-molecule akhiwe ilabhorethri aphindaphinda amandla amasosha omzimba okulwa namaseli ayingozi. Asebenza ngokunamathisela kumaphrotheni athile asendaweni engaphezulu kwamaseli anomdlavuza.
Lawa masosha omzimba angavimbela amangqamuzana omdlavuza ukuthi angakhuli ngokungalawuleki, asize amasosha omzimba abone amangqamuzana anomdlavuza ukuze aqedwe okuhlosiwe, noma aqale inqubo eyenza amangqamuzana anomdlavuza azibulale. Lena i-B-cell lymphoma immunotherapy ephumelela kakhulu.
Ama-Immune Checkpoint Inhibitors
Lena i-immunotherapy ephumelela kakhulu ye-t cell lymphoma. Ama-immune checkpoint inhibitors avimba amaprotheni athile kumaseli omzimba noma amaseli omdlavuza, okuvumela amasosha omzimba ukuthi abone futhi ahlasele amangqamuzana omdlavuza ngempumelelo.
Ngaphakathi kwesimiso sokuzivikela komzimba, amangqamuzana avamile anendawo yokuhlola amaprotheni enza izibopho namaprotheni kuma-T cell, okubonisa ukuthi ama-T cell ayeke ukuhlasela.
Ngakolunye uhlangothi, amangqamuzana omdlavuza angakhohlisa isimiso somzimba sokuzivikela ezifweni siwathathele amangqamuzana anempilo. Ama-inhibitors ayangenela ngokuphazamisa lokhu kubhanqa kwamaprotheni, aqinisekise ukuthi ama-T cell ahlonza ngokunembile futhi aqalise ukuhlasela kumaseli e-lymphoma.
I-Cellular Immunotherapy
I-Cellular immunotherapy iyinqubo yokuguqula amangqamuzana omzimba esiguli (ngokuvamile ama-T cell) ukuze athuthukise ikhono lawo lokuhlonza nokuqeda amangqamuzana omdlavuza.
I-CAR T-cell therapy (i-Chimeric Antigen Receptor T-cell) iyisibonelo esiphawulekayo se-cellular immunotherapy. Ngale ndlela, amaseli e-T akhiwe ngofuzo ukuze aveze isamukeli esibona amangqamuzana omdlavuza, enze impendulo enamandla neqondene nomuntu siqu yokulwa nomdlavuza.
Imithi Yokwelapha Yomdlavuza
Ezokwelapha imithi yokugoma umdlavuza shukumisa amasosha omzimba ukuze abone futhi alwe namaseli omdlavuza. Ngokungafani nemithi yokugoma ejwayelekile, ezama ukuvimbela izifo, le mithi yokugoma ihlose ukwelapha izimila ezikhona.
Le mithi yokugoma ingaklanywa ukuthi iqondise amaprotheni athile kumaseli omdlavuza futhi ikhuthaze ukusabela komzimba ngokumelene nomdlavuza.
Izimpilo Zangempela Ezithintwa Ukwelashwa Kwe-Immunotherapy
Hlangana noShawn, umfana oneminyaka engama-29 onesibindi waseHong Kong uhambo lwakhe lomdlavuza lwaqala enezimpawu zomkhuhlane, ukukhathala kanye nebala eliphaphathekile ngoMashi 2017.
UShawn uqale ukwelashwa kokungeniswa esibhedlela iPrince of Wales ngemuva kokutholakala ukuthi unalo I-acute B-lymphocytic leukemia. Ngemva kokwelashwa okuphumelelayo ngamakhemikhali nokwelashwa ngemisebe, wabonakala ephile saka ngo-April.
Kodwa-ke, ukuhlolwa komnkantsha ngo-Ephreli 19, 2018, kwathola ukuba khona kwe-10% ye-gonorrhea yezingane. Bebhekene nale nselelo, ochwepheshe base-Hong Kong baphakamise ukuthi ukwelashwa ngamakhemikhali okungokwesiko kungase kungenele futhi baphakamisa ukwelashwa kwe-CAR-T njengendlela ethembisa kakhudlwana.
Kwaba yilapho-ke u-Shawn enquma ukubamba iqhaza ocwaningweni lomtholampilo, enza ukuguqulwa kofuzo kuma-T-cell akhe ukuze akhe ama-T-cell “e-chimeric antigen receptor (CAR).” Lawa maseli ayingqayizivele enziwa ukuze aqondise amangqamuzana omdlavuza.
NgoMeyi 6, uShawn waba nomunye umjikelezo wokwelashwa ngamakhemikhali. Ngomhla ziyi-11 kuNhlaba, wathola ukujova amaseli e-CD19 CAR T. Imibiko egcwele iveze ukuthi akukho okudidayo ekuxhumaneni kwe-CSF, i-flow cytometry, i-bone marrow cell morphology, ukuhlolwa kwe-DNA, noma umbiko we-CAR-T ngemva kwamasonto amane okuqapha okuseduze nokuphathwa kwemiphumela emibi.
UShawn wayeseluleme ngokuphelele, okumaka impumelelo enkulu empini yakhe yokulwa nomdlavuza. Ngemva kokululama okumangalisayo, uShawn ulungiselela isigaba esilandelayo sohambo lwakhe—umnkantsha wamathambo nokufakelwa igazi lapho ebuyela eHong Kong.
Indaba yakhe ekhuthazayo igqamisa indima yenguquko ye-Immunotherapy ku-Lymphoma Treatment kanye nasekunqobeni isifo esibulalayo esinjengomdlavuza.
Masinqobe Umdlavuza Ndawonye!
Njengoba sigoqa ukuhlola kwethu emhlabeni we-immunotherapy yokwelashwa kwe-lymphoma, ake sibambelele kokuthile okubalulekile - ithemba.
Cabanga nge-immunotherapy noma i-CAR-T Cell Therapy njengeqhawe eqenjini lakho elilwa nomdlavuza, ikunikeza indlela entsha yalezo zikhathi ezinzima.
Impumelelo ngayinye indaba, zonke izinyathelo eziya phambili kwezesayensi, zifana nokukhanya okukhanyayo ohambweni lokulwa nomdlavuza. Uma wena noma othile omaziyo ekulolu hambo, khumbula ukuthi unamandla kunalokho ocabangayo, futhi zonke izinyathelo ozithathayo ukuze ufinyelele kulokhu kwelashwa uyimpumelelo.
Ngakho-ke asibhekane nakho ndawonye njengoba ithemba liyisikhali sethu esinamandla ekulweni nomdlavuza. Awuwedwa, futhi umgwaqo ongaphambili ugcwele amathuba okuba nekusasa eliqhakazile nelinempilo. Xhumana nathi namuhla ukuze uguqule lolu hambo oluyinselele lube kusasa eliqhakazile!
