E-United States, abantu abangaphezu kuka-70,000 kutholakala ukuthi bane-non-Hodgkin's lymphoma unyaka ngamunye, okubangelwa ukwanda ngokweqile kwamangqamuzana omzimba kuma-lymph nodes omzimba. Okuvame kakhulu ukusabalalisa i-B-cell lymphoma (DLBCL) enkulu, ehlanganisa cishe i-1/3 ye-lymphomas, futhi cishe ingxenye yalezi zicubu imelana nokwelashwa ngamakhemikhali kanye ne-immunotherapy. Uma i-lymphoma isuka kuzicubu ze-lymphatic, ukwanda kwamangqamuzana kubangela ukuthi ukwakheka okuphelele kwezicubu kuqhume, futhi amaseli avezwa amandla emishini njengokugeleza koketshezi.
Abacwaningi bahlole ukuthi la mandla oketshezi ahlobene kanjani nokumelana nesimila, futhi bakha idivayisi “ye-lymphoma microreactor” edalula i-lymphoma yomuntu ekugelezeni koketshezi, okufana namaphethini emithanjeni ye-lymphatic namanye ama-lymph node.
I-side-flow microreactor yeqembu ihlanganisa igumbi le-cellculture elixhunywe egumbini le-culture medium (uketshezi) ngokusebenzisa umgudu omncane wokumelana, obambezela ukugeleza koketshezi ukulingisa imikhumbi ye-lymphatic nezingxenye ze-lymph node. Lapho lihlola i-subpopulations ehlukene ye-DLCBL lymphoma, ithimba labacwaningi lithole ukuthi ama-subtypes athile ahlukaniswa ngokuvumelana nokuguqulwa kwama-molecule e-B cell receptor atholakala endaweni yeseli asabela ngendlela ehlukile kumandla oketshezi. Ithimba lithole ukuthi amandla oketshezi alawula amazinga okuvezwa kwe-integrin-adhesin nama-B cell receptors. Kunokugxambukela phakathi kwamasignali e-integrin ne-B cell receptor, okungasiza ukuchaza ukumelana kwamanye amathumba.
Okuphawulekayo ukuthi i-tumor subtype efanayo isabela ngendlela ehlukile emandleni emishini. Uma singaqonda indima yokuvuselela i-biophysical, singakwazi ukwazi ukuthi kungani amanye ama-lymphomas ezwela ekwelapheni, kuyilapho amanye ephikisana, khona-ke sizokwazi ukwelapha iziguli eziningi. Kubalulekile ukuqonda izici ezilawula ukusayinda kwe-B-cell receptor ngoba le ndlela iyinhloso eyinhloko yemithi yokwelapha emisha, futhi eminingana yayo isesivivinyweni somtholampilo. Ukuze uthole imininingwane eyengeziwe, sicela ushayele ICancerFax.
