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I-Peripheral T-cell lymphoma ibhekene nezinselelo

Yabelana ngalokhu okuthunyelwe

Umtholampilo waseCleveland wase-United States u-Eric D. His et al. Kubikwe ukuthi ukuxilongwa kwe-peripheral T cell lymphoma (PTCL) e-United States kuyahlukahluka kakhulu, futhi kuvame ukungabi nalwazi olubalulekile lwe-phenotypic ukuhlukanisa ngokuphelele i-lymphoma. Uma kubhekwa ukuhlukaniswa okuzayo kweWorld Health Organisation, kufanele kugcwaliswe igebe lokuhlola labamakayo abakhethiwe. Ukuxilongwa ngokunembile kuya kubaluleke kakhulu, kuzosiletha enkathini yokwelashwa okuqondisiwe kwe-PTCL. (Umtholampilo Lymphoma Myeloma Leuk. 2017; 17: 193-200.)

Ngokujula kokuqonda kwenani eliyingqayizivele le-peripheral T-cell lymphoma (PTCL), izindlela eziqondene nocwaningo oluthile ziyaqhubeka nokuvela, futhi ukuxilongwa okunembile kuya kubaluleke kakhulu.

Ucwaningo luthole idatha kusuka ekutadisheni kwezindlela zokwelashwa eziphelele ze-T-cell lymphoma (COMPLETE) yomgwaqo futhi lwenza ukuhlaziywa kwezindlela zeziguli ezine-histopathological diagnostic ye-PTCL. Ucwaningo OLUPHELELE luyisifundo esikhulu seqembu leziguli ezine-PTCL entsha e-United States. Imiphumela ikhombisa ukuthi iziguli ezingama-499 zabhaliswa ezikhungweni zemfundo ezingama-40 nasezikhungweni zomphakathi eziyi-15. Ifomu lokuhlola okuyisisekelo laqoqwa ezimweni ezingama-493, ezingama-435 (88%) zazo ezazitholakala ukuze zihlaziywe. Ukuxilongwa okuvame kakhulu yi-PTCL, i-PTCL engacacisiwe (i-PTCL-NOS), i-anaplastic cell cell lymphoma ne-angioimmunoblastic T cell lymphoma (AITL). Isiguli ngasinye sihlolisise isilinganiso samamaki ayi-10 (0-21). I-CD30 ihlolwa njalo, kepha ukubonakaliswa kwe-CD30 akuhambelani ezigulini ezingekho i-anaplastic large cell lymphoma. Kuphela yi-17% yeziguli ezine-PTCL-NOS ezihlole ukubonakaliswa kwe-PD1. I-CXCL13 iyinkomba ebucayi ye-AITL. Izinga lokukhulunywa kweziguli ze-AITL liyi-84%, kepha yi-3% kuphela yeziguli ze-PTCL-NOS ezitholile ukubonakaliswa kwe-CXCL13. Imiphumela yokuhlola yabamakeli abasizayo be-T cell markers yehlukile ezigulini ezikhungweni zemfundo nasemiphakathini. Izikhungo zemfundo zivame ukuhlola ukubonakaliswa kwe-PD1 ezigulini ezine-AITL (62% vs 12%, P = 0.01). 

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