Izinzuzo zokutholwa kusenesikhathi ekuhlolweni komdlavuza azikwazi ukubukelwa phansi. Kunobufakazi obuningi bokuthi ukubaluleka kokungenelela ngokushesha akukwazi nje ukuvimbela ukusakazeka kwalesi sifo, kodwa futhi kuthuthukise kakhulu izinga lokusinda cishe zonke izinhlobo zomdlavuza. Nokho, ukuhlonza izimpawu zokuqala zomdlavuza kuseyinselelo kososayensi. Nakuba manje, abacwaningi baseNyuvesi yaseBrunel kanye neNyuvesi yaseLeeds eLondon basanda kukhipha ubufakazi obusha obunganikeza ithemba lokuhlonzwa komdlavuza wesibindi kusenesikhathi.
Imiphumela yocwaningo ikhombisa ukuthi ukubonakaliswa kwama-enzyme e-glycolytic esibindini se-cirrhosis yangaphambi komdlavuza kwanda kakhulu, okuhlobene nengozi eyanda kakhulu yokuthuthukisa i-hepatocellular carcinoma (HCC), futhi ingakhomba amaqembu asengozini ye-HCC eyingozi. Imiphumela yalolu cwaningo olusha yanyatheliswa ku-"Forefront of Cellular and Developmental Biology" enesihloko esithi "Ukubonakaliswa okuphezulu kwezakhi zofuzo ze-glycolytic ku-cirrhosis yesibindi kuhlotshaniswa nengozi yokuba nomdlavuza wesibindi."
Ngamanye amazwi: ukuguqulwa kwe-glycolysis kwenzeka esikhathini esingaphambi komdlavuza, izinga lokuvezwa kwezakhi zofuzo ezihlobene ne-glycolysis lihlotshaniswa kahle nokuqhubekela phambili kwe-cirrhosis yesibindi kuya ku-HCC, futhi ukubikezelwa kweziguli ezine-biopsy HCC kubi. Lokhu kubonisa ukuthi ukubonakaliswa kwama-enzyme e-glycolytic kungasetshenziswa njenge-biomarker entsha ukubikezela ingozi ye-HCC ezigulini ezine-cirrhosis yesibindi esigabeni sakamuva. Ucwaningo olwengeziwe luyadingeka ukuze kunqunywe ukuthi lezi zinguquko ekukhulumeni kwezakhi zofuzo ziqinisekiswa njengezinguquko kumsebenzi we-glycolysis.
Imiphumela yocwaningo iveza izindlela ezithembisayo zokwenza ngcono ukusinda kwe-HCC ngokutholwa kusenesikhathi nokwelashwa. NgokukaDkt. Papa, ukushintshwa kwephrofayili yesisho se-glycolysis kumaseli e-cirrhotic kungase kube okuhlosiwe kwezokwelapha ezintsha ze-HCC. Isibonelo, ukuhlolwa kwemitholampilo okwamanje kuyaqhubeka ukuhlola indima yama-statins-asetshenziswa ukusiza ukuvimbela isifo senhliziyo nemithambo yegazi, ukuthuthukiswa kwe-HCC ezigulini ezine-cirrhosis yesibindi noma ukubuya kwe-HCC ngemva kokuhlinzwa kabusha, okungenzeka kakhulu ngokuvimbela ukuhlanganiswa kwe-cholesterol, ama-statins avimbela i-Glycolysis.
Ukutholwa Komdlavuza Wesibindi Kwasekuqaleni NgeGenethi Ye-Glycolytic
