U-Ruiwen Zhang no-Robert L. Boblitt abavela eNyuvesi yase-Houston basungule umuthi omusha womdlavuza we-pancreatic. The research was published in the Journal of Cancer Research. The drug targets two genes at the same time, and this breakthrough achievement is of great significance for the treatment of aggressive and deadly umdlavuza pancreatic.
Lesi sidakamizwa kulindeleke ukuthi sibe yisisekelo sokwakhiwa kwezidakamizwa zokwelapha ezinye izinhlobo zomdlavuza noma ezinye izifo. Umdlavuza wepancreatic wenzeka lapho amaseli e-pancreatic eqala ukwanda angalawuleki futhi akhule abe yizigaxa, futhi amangqamuzana omdlavuza avelayo angahlasela ezinye izingxenye zomzimba. Iningi lomdlavuza liqala endaweni yamanyikwe ekhiqiza ama-enzyme wokugaya ukudla. Izimpawu zifaka phakathi ubuhlungu besisu noma besisu, ukwehla kwesisindo okungalindelekile, kanye ne-jaundice (isikhumba esiphuzi). In addition, a person’s urine may appear dark yellow and itchy skin. There are two oncogenes associated with pancreatic cancer. There are two main ways for the drug to inhibit pancreatic cancer. They activate the nuclear factor of T cell 1 (NFAT1) and murine double microparticle 2 (MDM2), respectively. The latter gene regulates a isisu suppressor gene called p53. When there is no tumor suppressor p53, MDM2 can cause cancer. NFAT1 is used to up-regulate the expression of MDM2, thereby promoting tumor growth. Factors related to diet, nutrition and the environment can lead to increased levels of these factors in the cell.
Lapho ekhuluma ngalokhu okutholakele, uDkt Zhang uthe izidingo zomtholampilo zemithi emisha, esebenzayo nephephile yokwelashwa komdlavuza we-pancreatic bezingakahlangatshezwa. Ukuthola kwethu kubonisa intuthuko enkulu ocwaningweni lomdlavuza. Ubuye wathi: “Izidakamizwa eziningi zibhekisa isici esisodwa. Sithole ikhompuyutha ehlose izakhi zofuzo ezimbili ezihlobene nomdlavuza. “Isidakamizwa esisha siyinhlanganisela yokwenziwa engu-MA242. Isidakamizwa singadla amaprotheni amabili ngasikhathi sinye, ngaleyo ndlela sithuthukise ukusebenza kahle kokubulala isimila.
